Figure 1

Modeling of gene structures. Screen shot of the UCSC Genome browser displaying a gene that we predicted to be expressed in three variant transcripts and that is consequently characterized by three gene models (hp1_2a-c). The gene models show different transcription start sites, resulting in different N-terminal ends of the encoded proteins. All three models could be verified by ORF amplification, cloning, and sequence validation of the resulting entry clones.