Table 1 Gene expression fold-change differences between BTB-infected animals (n = 8) and control animals (n = 8) using real time qRT-PCR
Gene symbol | Gene name | Gene ontology (GO) function/s | Infected vs control group: relative expression | P-value |
|---|---|---|---|---|
EEF1G | Eukaryotic translation elongation factor 1 gamma gene | Protein binding, translation elongation factor activity | 1.46 ± 0.07 | < 0.0001 |
ADAM17 | ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme) gene | Metal ion binding, metalloendopeptidase activity, protein binding, zinc ion binding | -2.24 ± 0.28 | < 0.0001 |
CXCR3 | Chemokine (C-X-C motif) receptor 3 gene | C-X-C chemokine receptor activity, receptor activity, rhodopsin-like receptor activity | -2.22 ± 0.18 | < 0.0001 |
IER5 | Immediate early response 5 gene | Molecular function unknown | -2.28 ± 0.26 | < 0.0001 |
PHB2 | Prohibitin 2 gene | Estrogen receptor binding, protein binding, receptor activity, specific transcriptional repressor activity | -1.97 ± 0.19 | < 0.0001 |
STK17B | Serine/threonine kinase 17b (apoptosis-inducing) gene | ATP binding, nucleotide binding, protein serine/threonine kinase activity, transferase activity | -1.39 ± 0.11 | 0.0007 |
CD84 | CD84 antigen gene | Molecular function unknown | 1.77 ± 0.48 | 0.0009 |
MCL1 | Myeloid cell leukemia sequence 1 (BCL2-related) gene | Protein binding, protein channel activity, protein heterodimerization activity | -1.07 ± 0.31 | 0.0013 |
CCL1 | Chemokine (C-C motif) ligand 1 gene | Chemokine activity | -1.33 ± 0.09 | 0.0014 |
TBK1 | TANK-binding kinase 1 gene | ATP binding, nucleotide binding, protein serine/threonine kinase activity, signal transducer activity, transferase activity | -1.56 ± 0.19 | 0.0037 |
AKT1 | V-akt murine thymoma viral oncogene homolog 1 gene | ATP binding, nucleotide binding, protein kinase activity, serine/threonine kinase activity, transferase activity | -1.49 ± 0.16 | 0.0042 |
IL8 | Interleukin 8 gene | Chemokine activity, interleukin-8 receptor binding, protein binding | -1.64 ± 0.64 | 0.0048 |
TLR2 | Toll-like receptor 2 gene | Gram-positive bacterial binding, lipopolysaccharide receptor activity, peptidoglycan binding, transferase activity | -2.37 ± 0.89 | 0.0108 |
PRKCB1 | Protein kinase C, beta 1 gene | ATP binding, calcium ion binding, diacylglycerol binding, protein kinase C activity, transferase activity, zinc ion binding | -1.13 ± 0.35 | 0.0111 |
TLR4 | Toll-like receptor 4 | Lipopolysaccharide binding, protein binding, transferase activity, transmembrane receptor activity | -1.22 ± 0.55 | 0.0116 |
NFKB1 | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) gene | Protein binding, transcription factor activity | -1.02 ± 0.50 | 0.0228 |
IL16 | Interleukin 16 (lymphocyte chemoattractant factor) gene | Cytokine activity, protein binding | 1.33 ± 0.17 | 0.0326 |
RPS6KB2 | Ribosomal protein S6 kinase, 70 kDa, polypeptide 2 gene | ATP binding, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity | -0.92 ± 0.29 | 0.0342 |
BCL2 | B-cell CLL/lymphoma 2 gene | Identical protein binding | -1.62 ± 0.61 | 0.0395 |
TNF | Tumor necrosis factor (TNF superfamily, member 2) gene | Protein binding, tumor necrosis factor receptor binding | 0.89 ± 0.46 | 0.0426 |
CD81 | CD81 molecule gene | Protein binding | -1.23 ± 0.41 | 0.0477 |
NFATC4 | Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 gene | Transcription coactivator activity, transcription factor activity | 13.22 ± 6.42 | 0.0482 |