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Table 1 Gene expression fold-change differences between BTB-infected animals (n = 8) and control animals (n = 8) using real time qRT-PCR

From: Innate gene repression associated with Mycobacterium bovis infection in cattle: toward a gene signature of disease

Gene symbol Gene name Gene ontology (GO) function/s Infected vs control group: relative expression P-value
EEF1G Eukaryotic translation elongation factor 1 gamma gene Protein binding, translation elongation factor activity 1.46 ± 0.07 < 0.0001
ADAM17 ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme) gene Metal ion binding, metalloendopeptidase activity, protein binding, zinc ion binding -2.24 ± 0.28 < 0.0001
CXCR3 Chemokine (C-X-C motif) receptor 3 gene C-X-C chemokine receptor activity, receptor activity, rhodopsin-like receptor activity -2.22 ± 0.18 < 0.0001
IER5 Immediate early response 5 gene Molecular function unknown -2.28 ± 0.26 < 0.0001
PHB2 Prohibitin 2 gene Estrogen receptor binding, protein binding, receptor activity, specific transcriptional repressor activity -1.97 ± 0.19 < 0.0001
STK17B Serine/threonine kinase 17b (apoptosis-inducing) gene ATP binding, nucleotide binding, protein serine/threonine kinase activity, transferase activity -1.39 ± 0.11 0.0007
CD84 CD84 antigen gene Molecular function unknown 1.77 ± 0.48 0.0009
MCL1 Myeloid cell leukemia sequence 1 (BCL2-related) gene Protein binding, protein channel activity, protein heterodimerization activity -1.07 ± 0.31 0.0013
CCL1 Chemokine (C-C motif) ligand 1 gene Chemokine activity -1.33 ± 0.09 0.0014
TBK1 TANK-binding kinase 1 gene ATP binding, nucleotide binding, protein serine/threonine kinase activity, signal transducer activity, transferase activity -1.56 ± 0.19 0.0037
AKT1 V-akt murine thymoma viral oncogene homolog 1 gene ATP binding, nucleotide binding, protein kinase activity, serine/threonine kinase activity, transferase activity -1.49 ± 0.16 0.0042
IL8 Interleukin 8 gene Chemokine activity, interleukin-8 receptor binding, protein binding -1.64 ± 0.64 0.0048
TLR2 Toll-like receptor 2 gene Gram-positive bacterial binding, lipopolysaccharide receptor activity, peptidoglycan binding, transferase activity -2.37 ± 0.89 0.0108
PRKCB1 Protein kinase C, beta 1 gene ATP binding, calcium ion binding, diacylglycerol binding, protein kinase C activity, transferase activity, zinc ion binding -1.13 ± 0.35 0.0111
TLR4 Toll-like receptor 4 Lipopolysaccharide binding, protein binding, transferase activity, transmembrane receptor activity -1.22 ± 0.55 0.0116
NFKB1 Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) gene Protein binding, transcription factor activity -1.02 ± 0.50 0.0228
IL16 Interleukin 16 (lymphocyte chemoattractant factor) gene Cytokine activity, protein binding 1.33 ± 0.17 0.0326
RPS6KB2 Ribosomal protein S6 kinase, 70 kDa, polypeptide 2 gene ATP binding, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity -0.92 ± 0.29 0.0342
BCL2 B-cell CLL/lymphoma 2 gene Identical protein binding -1.62 ± 0.61 0.0395
TNF Tumor necrosis factor (TNF superfamily, member 2) gene Protein binding, tumor necrosis factor receptor binding 0.89 ± 0.46 0.0426
CD81 CD81 molecule gene Protein binding -1.23 ± 0.41 0.0477
NFATC4 Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 gene Transcription coactivator activity, transcription factor activity 13.22 ± 6.42 0.0482
  1. Relative expression fold change values are shown with standard errors. Also shown are P-values from t-tests between the two groups.