Table 2 Microarrays results

21 days

   Up-regulated genes

Morphogenesis, organogenesis and cell differentiation

Cadherin 1

Cadherin EGF LAG seven-pass G-type receptor 3

Cardiotrophin 1

Early growth response 2

Endothelial cell-specific molecule 1

Forkhead box G1

Gamma-aminobutyric acid (GABA) B receptor 1

Glutamate receptor, metabotropic 5

Glypican 2 (cerebroglycan)

NAD(P)H dehydrogenase, quinone 2

Odd Oz/ten-m homolog 2 (Drosophila)

Parathyroid hormone-like peptide

Pregnancy-induced growth inhibitor

RAS-like family 11 member B

Tenascin R

Wilms tumor 1

Other transcription factors

CUG triplet repeat, RNA-binding protein 2

Forkhead box A1 (Hnf3a)

HNF-3/forkhead homolog-1 (Hfh1)

Jun dimerization protein 2

Nuclear transcription factor-Y gamma

TEA domain family member 2

Transcription elongation factor A (SII), 2

Transcription factor 2

Transcription factor 4

Cell proliferation

Alpha-2-glycoprotein 1, zinc

Calcium/calmodulin-dependent protein kinase II beta subunit

Chemokine (C-X-C motif) ligand 10

Insulin receptor substrate 2

Neutrophil cytosolic factor 1

Platelet-derived growth factor, C polypeptide

Upregulated by 1,25-dihydroxyvitamin D-3

Response to stress

Aryl hydrocarbon receptor

Chemokine (C-C motif) ligand 5

Fc receptor, IgE, low affinity II, alpha polypeptide

Heat shock 27 kD protein family, member 7

Heat shock factor 2

Myeloid cell leukemia sequence 1

Nitric oxide synthase 2, inducible

Oxidized low density lipoprotein (lectin-like) receptor 1

Peptidoglycan recognition protein 1

Thioredoxin reductase 1

Signal transduction

5-hydroxytryptamine (serotonin) receptor 2A

Activin receptor interacting protein 1

Agouti

Angiotensin receptor-like 1

Growth factor receptor bound protein 2-associated protein 2

Growth hormone releasing hormone

Guanylate cyclase 1, soluble, beta 2

MAS-related G-protein coupled receptor, member G

Mcf.2 transforming sequence-like

Membrane-spanning 4-domains, subfamily A, member 2

Protein kinase, cAMP-dependent, regulatory, type 2, alpha

Rho guanine nucleotide exchange factor (GEF) 1

Rho guanine nucleotide exchange factor 7

Cell-cell signaling

4-aminobutyrate aminotransferase

Discs, large (Drosophila) homolog-associated protein 2

Gap junction membrane channel protein beta 5

Metabolism

11-beta-hydroxysteroid dehydrogenase

Acetyl-coenzyme A carboxylase alpha

Aldehyde oxidase 1

Alpha 1,2-fucosyltransferase C gene

Apolipoprotein A-I

Cholinergic receptor, muscarinic 3

Diazepam binding inhibitor-like 5

Elastase 2

Fatty acid binding protein 3

FK506 binding protein 1b

Glucosidase, alpha; acid (glycogen storage disease type II)

Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 5

Nicotinamide nucleotide transhydrogenase

Peptide/histidine transporter PHT2

Phosphate cytidylyltransferase 1, choline, alpha isoform

Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1

Proteasome (prosome, macropain) 26S subunit, ATPase 3

Protein kinase C, gamma

Serine/threonine kinase 2

Small glutamine rich protein with tetratricopeptide repeats 2

Succinate-semialdehyde dehydrogenase

Transmembrane protease, serine 8 (intestinal)

Valosin-containing protein

Transport

Adducin 1 (alpha)

Apolipoprotein A-V

Cholinergic receptor, nicotinic, alpha polypept. 1

CUB and zona pellucida-like domains 1

Epidermal growth factor

Gamma-aminobutyric acid A receptor, gamma 2

Glutamate receptor, ionotropic, kainate 4

Glutamate receptor, ionotropic, NMDA2D

Olfactory receptor 226

Potassium inwardly-rectifying channel, subfamily J, member 6

RAB10, member RAS oncogene family

Rabaptin, RAB GTPase binding effector protein 2

Sodium channel, voltage-gated, type II, beta polypeptide

Solute carrier family 12, member 4

Solute carrier family 13, member 1

Synaptotagmin 8

Cell organization

Adaptor-related protein complex 3, mu 2 subunit

ATP-dependent, RNA helicase

Bassoon

Cadherin-8

Integrin alpha 5

Myoglobin

Synaptotagmin 1

Trans-golgi network protein 1

Other

Alpha-1-B glycoprotein

Aortic preferentially expressed gene 1

Arfaptin 1

CDC91 cell division cycle 91-like 1 (S.cerevisiae)

Delta-like 1 homolog (Drosophila)

Glycoprotein, synaptic 2

Guanylate cyclase activator 2A

Heparan sulfate proteoglycan, perlecan domain I

Heat-responsive protein 12

Insulin-like 6

Kinesin-related protein KRP5

Luteinizing hormone beta

Ly6-C antigen

Mitochondrial capsule selenoprotein

Neural visinin-like Ca2+-binding protein type 2

NIMA related kinase 2

Nuclear GTPase PIKE

Nucleoporin 98

Oxytocin receptor

Olfactory-specific cytochrome P-450

Potassium channel tetramerisation domain containing 13

Proline-rich protein 15

RAB8A, member RAS oncogene family

Regucalcin gene promotor region related protein

Ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)

Ring finger protein 38

Serine protease inhibitor

Signal recognition particle 54 kDa

Sodium-cotransporter rkST1

Synaptosomal-associated protein, 91 kDa homolog (mouse)

Telomerase catalytic subunit

Titin

Ubiquitin specific protease 11

Zinc finger protein 14 (DZF14)

Zinc finger, DHHC domain containing 7

   Down-regulated genes

Glutamate decarboxylase 1

35 days

Glutamate decarboxylase 1

50 days

   Up-regulated genes

Carboxylesterase 1

Carboxypeptidase A1 (pancreatic)

Corticotropin releasing hormone 1

Ectonucleotide pyrophosphatase/phosphodiesterase 5

Glucagon receptor, transcript variant 2

Glycoprotein 2 (zymogen granule membrane)

Malic enzyme 1

Nuclear receptor subfamily 4, group A, member 1

Transcription elongation factor A2

Tryptophan hydroxylase

   Down-regulated genes

Actinin alpha 3

Creatine kinase, muscle form

Glutamate decarboxylase 1

Myosin, light polypeptide 2

Parvalbumin (calcium binding protein)

Titin

Troponin I, skeletal, fast 2

Troponin-c

100 days

Translin

Whey acidic protein