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Table 3 Selection of genes with fold change between unfused and fused sutures and between each unfused suture site.

From: Unravelling the molecular control of calvarial suture fusion in children with craniosynostosis

Gene Name Affymetrix ID Description Fold U-F P-value U-F Unfused Lambdoid Unfused Coronal Unfused Sagittal
Signalling
   ANGPTNL2 213004_at angiopoietin-like 2 6.67 0.024 1.00 -1.45 -2.87
   EGFR 201983_s_at epidermal growth factor receptor 2.71 0.038 1.00 1.02 1.20
   EPHA3 206071_s_at EPH receptor A3 2.92 0.480 1.00 -2.06 -5.33
   EPHA4 206114_at EPH receptor A4 2.75 0.173 1.00 -1.19 -1.60
   EPHB2 209589_s_at EPH receptor B2 2.39 0.093 1.00 1.22 -1.12
   FGFR2 208228_s_at fibroblast growth factor receptor 2 3.36 0.294 1.00 -1.42 -3.72
   FZD1 204451_at frizzled homolog 1 (Drosophila) 2.13 0.326 1.00 -1.08 -2.41
   IL11RA 204773_at interleukin 11 receptor, alpha 5.90 0.003 1.00 1.49 1.32
   TGFB2 209909_s_at transforming growth factor, beta 2 3.76 0.096 1.00 -1.01 -2.08
   FGFR1 222164_at fibroblast growth factor receptor 1 1.23 0.480 1.00 -1.29 1.12
   FGFR3 204379_s_at fibroblast growth factor receptor 3 1.42 0.480 1.00 1.23 1.33
   WNT5A 205990_s_at wingless-type MMTV integration site family, member 5A 1.24 0.857 1.00 -1.03 -5.18
   IL17R 205707_at interleukin 17 receptor -2.67 0.480 1.00 -1.25 3.35
   OLFM4 212768_s_at olfactomedin 4 -6.69 0.480 1.00 -2.15 6.77
   WIF1 204712_at WNT inhibitory factor 1 -3.19 0.480 1.00 -1.27 5.37
Structural
   COL2A1 213492_at collagen, type II, alpha 1 (primary osteoarthritis) 7.21 0.390 1.00 -20.66 -3.84
   COL3A1 215077_at collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV) 6.32 0.072 1.00 1.24 -3.84
   COL8A2 221900_at collagen, type VIII, alpha 2 11.49 0.092 1.00 -1.23 -12.73
   COL10A1 217428_s_at collagen, type X, alpha 1(Schmid metaphyseal chondrodysplasia) 14.65 0.407 1.00 -41.66 -17.28
   FBLN1 202995_s_at fibulin 1 12.88 0.025 1.00 -1.39 -1.92
   FMOD 202709_at fibromodulin 5.41 0.024 1.00 -1.09 -1.70
   NELL2 203413_at NEL-like 2 (chicken) 6.40 0.270 1.00 -4.21 -3.01
   PRELP 204223_at proline arginine-rich end leucine-rich repeat protein 10.65 0.009 1.00 1.20 -1.31
   THBS2 203083_at thrombospondin 2 6.62 0.069 1.00 -1.26 -2.47
   COL1A2 202404_s_at collagen, type I, alpha 2 1.05 0.480 1.00 -1.01 -1.06
   CORO1A 209083_at coronin, actin binding protein, 1A -5.08 0.480 1.00 -1.05 11.73
Transcription
   BHLH3 221530_s_at basic helix-loop-helix domain containing, class B, 3 5.95 0.093 1.00 -2.23 -4.76
   CART1 206837_at cartilage paired-class homeoprotein 1 2.06 0.533 1.00 16.21 2.38
   HLF 204753_s_at hepatic leukemia factor 3.54 0.210 1.00 -2.55 -6.81
   JUN 201465_s_at v-jun sarcoma virus 17 oncogene homolog (avian) 4.41 0.161 1.00 3.14 2.50
   PITX2 207558_s_at paired-like homeodomain transcription factor 2 3.45 0.279 1.00 1.63 -2.08
   SIX2 206510_at sine oculis homeobox homolog 2 (Drosophila) 2.72 0.136 1.00 -1.09 -1.70
   FOS 209189_at v-fos FBJ murine osteosarcoma viral oncogene homolog 1.40 0.745 1.00 14.96 4.13
   FOSB 202768_at FBJ murine osteosarcoma viral oncogene homolog B 1.83 0.695 1.00 54.37 20.22
   FOXD1 206307_s_at forkhead box D1 1.49 0.499 1.00 -4.71 -5.17
   JUNB 201473_at jun B proto-oncogene 1.28 0.703 1.00 3.61 2.95
   MEOX2 206201_s_at mesenchyme homeo box 2 (growth arrest-specific homeo box) 1.66 0.495 1.00 -3.99 -7.74
   MSX2 210319_x_at msh homeo box homolog 2 (Drosophila) 1.95 0.464 1.00 -1.14 -2.23
   TWIST1 213943_at twist homolog 1 (Saethre-Chotzen syndrome) 1.50 0.476 1.00 -1.20 -1.27
   LHX6 219884_at LIM homeobox 6 -1.80 0.050 1.00 -1.07 -1.03
   SHOX2 210135_s_at short stature homeobox 2 -3.44 0.480 1.00 -1.00 4.50
   PAX5 221969_at paired box gene 5 (B-cell lineage specific activator) -4.20 0.480 1.00 -1.69 6.25
Catalytic Activity
   ROR1 205805_s_at receptor tyrosine kinase-like orphan receptor 1 2.26 0.095 1.00 1.21 -1.14
   HDHD1A 203974_at haloacid dehalogenase-like hydrolase domain containing 1A -1.78 0.018 1.00 1.05 1.05
   ALOX5 204446_s_at arachidonate 5-lipoxygenase -5.55 0.480 1.00 -1.30 6.76
   ANXA3 209369_at annexin A3 -7.17 0.480 1.00 -1.30 6.76
Transporter
   C1QTNF3 220988_s_at C1q and tumor necrosis factor related protein 3 20.25 0.007 1.00 -1.52 -4.92
   RBP4 219140_s_at retinol binding protein 4 (plasma) KIAA1922 37.38 0.003 1.00 -1.35 -2.53
   APOC1 204416_x_at apolipoprotein C-I -2.01 0.480 1.00 1.08 5.06
Binding
   AGC1 217161_x_at aggrecan 1 (chondroitin sulfate proteoglycan 1) 6.16 0.024 1.00 -1.25 -1.56
   CCND1 208711_s_at cyclin D1 2.13 0.449 1.00 1.38 2.24
   GPC3 209220_at glypican 3 7.13 0.050 1.00 1.26 -3.34
   HAPLN1 205523_at hyaluronan and proteoglycan link protein 1 7.10 0.050 1.00 -1.96 -4.01
   INHBA 210511_s_at inhibin, beta A (activin A, activin AB alpha polypeptide) 6.94 0.006 1.00 -1.36 -3.03
   MFAP4 212713_at microfibrillar-associated protein 4 16.50 0.001 1.00 1.32 -1.86
   OGN 218730_s_at osteoglycin (osteoinductive factor, mimecan) 5.71 0.166 1.00 -1.41 -4.65
   POSTN 214981_at periostin (osteoblast specific factor 2) 5.87 0.101 1.00 -1.16 -1.60
   PTN 209466_x_at pleiotrophin (osteoblast specific factor 1) 6.25 0.031 1.00 -1.14 -1.78
   S100A10 200872_at S100 calcium binding protein A10 (annexin II ligand) 2.01 0.096 1.00 -1.04 -1.60
   CCND3 201700_at cyclin D3 -2.60 0.480 1.00 -1.00 3.62
   FCN1 205237_at ficolin (collagen/fibrinogen domain containing) 1 -5.45 0.480 1.00 -1.46 12.39
   FGR 208438_s_at Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog -3.03 0.480 1.00 -1.13 5.75
   S100A12 205863_at S100 calcium binding protein A12 (calgranulin C) -8.86 0.480 1.00 -2.63 15.19
Enzyme regulator
   MMP14 202827_s_at matrix metalloproteinase 14 (membrane-inserted) 2.39 0.226 1.00 -1.22 -1.84
   TIMP3 201149_s_at tissue inhibitor of metalloproteinase 3 2.22 0.467 1.00 -1.71 -3.43
   CASP1 211366_x_at caspase 1, apoptosis-related cysteine protease -2.73 0.165 1.00 -1.30 1.01
   MME 203434_s_at membrane metallo-endopeptidase (CD10) -3.23 0.476 1.00 -2.35 -1.29
   MMP8 207329_at matrix metalloproteinase 8 (neutrophil collagenase) -5.81 0.480 1.00 -2.36 1.69
   RASGRP2 208206_s_at RAS guanyl releasing protein 2 (calcium and DAG-regulated) -2.60 0.480 1.00 1.02 3.02
Unknown Function
   CYFIP2 220999_s_at cytoplasmic FMR1 interacting protein 2 -2.68 0.031 1.00 1.14 1.09
  1. Gene expression fold change (U-F) is presented for unfused sutures (n = 8) compared to fused/fusing sutures (n = 6), with corresponding P-values, and for combined unfused coronal (n = 4) and unfused sagittal (n = 2) sutures compared to unfused lambdoid sutures (n = 2).