Domain Connectivity Filtering. a) Dependency of domain maximum degree with the number of components (domains) in the largest cluster. The threshold used for the analysis was C = 8 (shown in red). b) Domain connectivity graphs. Dots (nodes) indicate domains connected to other domains by virtue of a detected fusion event, lines (edges) represent the inferred functional associations obtained by fusion analysis. The leftmost graph shows connectivity of domains without cutoff, the rightmost graph shows domain connectivity with a cutoff threshold of C = 8. c) Length distribution of domains with connectivities of C = 8 (blue bars) and C>8 (green bars). The x-axis shows domain length bins in amino acid residues, the y-axis represents the percentage of domains of this length.