MPAKT mouse treated with RAD001. A) Heat map of normalized gene expression for the top 64 genes correlating with AKT expression and RAD001 treatment in the prostates of transgenic MPAKT mice. B) Association of pathway terms (Squares) with the 64 genes (circles) associated with RAD001 treatment of MPAKT mice. Size of square indicates confidence of associations, thickness of connecting line correlates with the number of abstracts linking any pair of term and gene. C) Protein lysates prepared from the VP of individual MPAKT and WT mice either treated with RAD001 (+) or with placebo (-) for 48 hours were immunoblotted with anti-Hif1α and anti-tubulin as indicated. Lower panel shows the densitometric ratio of Hif1α and tubulin.