The fungus Ustilago maydis and humans share disease-related proteins that are not found in Saccharomyces cerevisiae

Table 3 Functional classification of predicted proteins

	Protein number^¶	P-value
A. *U. maydis – S. cerevisiae* *
1. Biosynthesis*	75	1,7e-33
2. Spore formation/budding/cell polarity	68	1.9e-15
3. Transport**	49	1.3e-18
4. Ion homeostasis	36	4.2e-12
5. Stress response^$	35	7.5e-11
6. Detoxification/Resistance	29	1.4e-10
7. Unknown function^†	96	1
B. *U. maydis – H. sapiens* *
1. mRNA splicing	38	6.9e-17
2. Protein modification/degradation	29	2.4e-04
3. G-protein-mediated signalling	17	3,6e-06
4. Amino acid degradation	14	4.4e-09
5. Oxidation of fatty acids	10	1.1e-05
6. Unknown function^†	222	1
C. *S. cerevisiae – H. sapiens* *
1. Biosynthesis, secondary^§	105	3.0e-05
2. Protein fate, – modification	89	7.4e-06
3. Oxidative stress response	8	3.7e-03
4. tRNA modification	7	3.4e-03
5. Unknown function^†	46	1

*Note that proteins can appear in more than one functional category. In addition, numerous proteins are assigned to additional functional classes that are not listed.
^¶ Only those predicted proteins were considered that (1) show more than 20% identity with either in both organisms and (2) show at least 10 % less homology in the third partner
*Amino acids/vitamins/cofactors
**Amino acids/lipids/carbohydrates
^$Salt and oxidative stress
^§Polyamines, vitamins, co-factors and other secondary products
^†Predicted proteins are not found in the COGs or FunCat database

ISSN: 1471-2164