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Table 1 Summary of the clinicopathological data of the 177 and 89 STS samples

From: Diagnostic and prognostic gene expression signatures in 177 soft tissue sarcomas: hypoxia-induced transcription profile signifies metastatic potential

Factor Diagnostic signature n = 177 Prognostic signature n = 89
Sex (male/female) 88/89 50/39
Age, median (range) years 66 (11 – 94) 69 (33 – 93)
Histological subtypes   
   Malignant fibrous histiocytoma (MFH) 61¤ 54
   Leiomyosarcoma 40 27
   Synovial sarcoma 32 0
   Liposarcoma 16* 0
   Malignant peripheral nerve sheath tumor 8 0
   Myofibroblastic sarcoma 5 5
   STS not otherwise specified 4 2
   Extraskeletal osteosarcoma 3 1
   Fibrosarcoma 3 0
   Gastrointestinal stromal tumors 3 0
   Epithelioid sarcoma 1 0
   Malignant mesenchymoma 1 0
Grade   
   II 6 1
   III 32 12
   IV 139 76
Tumor size   
   Median (range) cm 8 (1–40) 9 (2–30)
   < 5 cm 41 19
   5 – 10 cm 74 38
   >10 cm 62 32
Tumor location   
   Extremity 144 78
   Trunk wall 19 7
   Retroperitoneum 7 3
   Other 7# 1
Tumor depth   
   Superficial 37 22
   Deep 118 63
   Unclassified 22 4
Necrosis   
   Absent 48 23
   Present 106 66
   Unclassified 23 0
Vascular invasion   
   Absent 121 72
   Present 31 17
   Unclassified 25 0
Treatment   
   Surgery alone 107 58
   Postoperative radiotherapy 51 22
   Postoperative chemotherapy 3 2
   Postoperative radio- and chemotherapy 10 7
   Preoperative radio- or chemotherapy 6 0
Surgery   
   Wide 90 57
   Marginal 66 28
   Intralesional 15 4
   Unclassified 6 0
  1. ¤Includes 47 storiform, 13 myxoid, and 1 giant-cell MFH
  2. * Includes 4 myxoid/round cell liposarcomas, 6 dedifferentiated liposarcomas, and 6 pleomorphic liposarcomas
  3. # Includes localizations in the abdomen, the mediastinum, and the head and neck