Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program

BMC Genomics

Table 2 Age-related effects on expression of p53-related genes in young and old C57BL/6 mouse gatrocnemius tissue.

Gene	Expression Ratio	% CR Prevention	Posterior Probability	Representative Public ID
Genes That Encode Proteins That Bind P53
myogenic differentiation 1	1.52	101	0.9983	NM_010866
pleiomorphic adenoma gene-like 1	1.59	153	0.9987	AF147785
Genes Whose Expression is Activated by P53 Activity
p21	1.92	67	1.0000	AK007630
GADD45a	1.79	44	1.0000	NM_007836
DNA-damage-inducible transcript 4	1.39	-2	0.9980	AK017926
dual specificity phosphatase 1	1.51	43	0.9992	NM_013642
IGF binding protein 3	1.28	106	0.9875	AV175389
keratin complex 1, acidic, gene 15	1.26	94	0.9890	NM_008469
mcl1	1.44	52	0.9894	BC003839
mcl1	1.45	27	0.9790	AV274748
mcl1	1.46	11	0.9539	AV318494
p53 apoptosis effector related to Pmp22	1.75	133	1.0000	NM_022032
sestrin 1	1.43	103	1.0000	BG076140
sestrin 1	1.44	60	0.9999	AV016566
pten	1.46	114	0.9798	AA214868
paternally expressed 3	1.52	99	0.9962	BM200248
retinoblastoma 1	1.50	63	1.0000	NM_009029
Genes That Inhibit P53 Activity
B-cell leukemia/lymphoma 6	0.60	130	1.0000	U41465
cyclin G1	0.63	110	0.9980	BG065754
dual specificity phosphatase 10	0.48	46	1.0000	NM_022019
dual specificity phosphatase 10	0.66	49	0.9990	NM_022019
mdm2	0.63	90	0.9999	X58876

The above p53-related genes were selected from a list of 712 transcripts that were determined to be differentially expressed in young and old gastrocnemius mouse tissue using an empirical Bayes (EB) hierarchical modeling approach called EBarrays [56, 57] at posterior probability (PP) > .90. Genes listed more than once represent independent probes on the MOE430A array for the same gene identified in this statistical screen. Expression ratio = old (O) expression levels/young (Y) expression levels.

ISSN: 1471-2164