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Table 2 Age-related effects on expression of p53-related genes in young and old C57BL/6 mouse gatrocnemius tissue.

From: Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program

Gene Expression Ratio % CR Prevention Posterior Probability Representative Public ID
Genes That Encode Proteins That Bind P53
myogenic differentiation 1 1.52 101 0.9983 NM_010866
pleiomorphic adenoma gene-like 1 1.59 153 0.9987 AF147785
Genes Whose Expression is Activated by P53 Activity
p21 1.92 67 1.0000 AK007630
GADD45a 1.79 44 1.0000 NM_007836
DNA-damage-inducible transcript 4 1.39 -2 0.9980 AK017926
dual specificity phosphatase 1 1.51 43 0.9992 NM_013642
IGF binding protein 3 1.28 106 0.9875 AV175389
keratin complex 1, acidic, gene 15 1.26 94 0.9890 NM_008469
mcl1 1.44 52 0.9894 BC003839
mcl1 1.45 27 0.9790 AV274748
mcl1 1.46 11 0.9539 AV318494
p53 apoptosis effector related to Pmp22 1.75 133 1.0000 NM_022032
sestrin 1 1.43 103 1.0000 BG076140
sestrin 1 1.44 60 0.9999 AV016566
pten 1.46 114 0.9798 AA214868
paternally expressed 3 1.52 99 0.9962 BM200248
retinoblastoma 1 1.50 63 1.0000 NM_009029
Genes That Inhibit P53 Activity
B-cell leukemia/lymphoma 6 0.60 130 1.0000 U41465
cyclin G1 0.63 110 0.9980 BG065754
dual specificity phosphatase 10 0.48 46 1.0000 NM_022019
dual specificity phosphatase 10 0.66 49 0.9990 NM_022019
mdm2 0.63 90 0.9999 X58876
  1. The above p53-related genes were selected from a list of 712 transcripts that were determined to be differentially expressed in young and old gastrocnemius mouse tissue using an empirical Bayes (EB) hierarchical modeling approach called EBarrays [56, 57] at posterior probability (PP) > .90. Genes listed more than once represent independent probes on the MOE430A array for the same gene identified in this statistical screen. Expression ratio = old (O) expression levels/young (Y) expression levels.