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Table 4 Drug binding residues

From: The actin multigene family of Paramecium tetraurelia

  phalloidin latrunculin Ab
  G158 R177 D179 D157 R183/D184 R210/D211 K21/E214/K215
actin1-1 G R D S R A R D K E K
actin1-4 G R D S R A R D K E K
actin1-5 G R D S R A R D K E K
actin1-6 G K N S R L K N K E R
actin1-7 G R D S R A K D K E K
actin1-8 G R Y S S T R D K E K
actin1-9 G R C C N A D I K E K
actin2-1 G K H S R D N A D T K
actin3-1 G R D S Y A S L Y V A
actin4-1 G Q P I E I P D K F I
actin5-1(ARP1) G R D V R D I I K Y K
actin6-1 G F S L A E D K S E E
actin7-1(ARP2/4) G R D C E Y S L M Y G
actin8 G F N S K S L Q Q Q Q
actin9(ARP10) G G Y L R E C Y D T Y
ARP2-1 G R N A R H R E K E A
ARP3-1 G H P S R D R E K E K
ALP1-1(ARP5) G R N L L N L Q Q E R
  1. a Analysis was performed using Clustal W.
  2. b each combination represents an allele in yeast mutagenesis studies.
  3. Bold and italic, all interacting residues are present; italic, not all residue are present.