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Table 2 The ten most significantly enriched genes in cortex, hippocampus, striatum and cerebellum, respectively, compared to all other samples

From: Gene expression profiles in rat brain disclose CNS signature genes and regional patterns of functional specialisation

AB1700 Probe ID

Primary Gene IDa

Delta scoreb

Foldc

Gene Symbol

Gene Name

'Validation'd

Source

Cortex

       

20757128

301423

21.2

11.5

LOC501145

similar to KIAA1034-like DNA binding protein

+

Human GeneAtlas

20804233

rCG56789

21.1

4.9

unassigned

unassigned

NA e

No record

22394757

116470

20.9

7.2

Stx1a

syntaxin 1A (brain)

+

Ratlas

22106387

rCG41482

20.6

16.7

unassigned

unassigned

NA

No record

21180100

289440

20.5

5.1

Abhd7 predicted

abhydrolase domain containing 7 (predicted)

NA

No record

21191309

25033

20.1

7.4

Sstr1

somatostatin receptor 1

-

Ratlas

21546223

363102

18.8

5.3

unassigned

unassigned

NA

No record

20813345

312607

18.2

3.9

Pdzrn3 predicted

PDZ domain containing RING finger 3 (predicted)

+

Mouse GeneAtlas

21401322

311078

17.9

5.9

LOC311078

similar to T-Brain-1

+

Mouse GeneAtlas

21849766

rCG63352

17.7

4.9

unassigned

unassigned

NA

No record

Hippocampus

       

21875182

311861

33.3

14.4

RGD1309097 predicted

similar to Hypothetical protein FLJ14810 (predicted)

+

Mouse GeneAtlas

22010557

25153

25.8

9.3

Mas1

MAS1 oncogene

+

Ratlas

22272616

288979

23.3

9.1

LOC288979

similar to complement component 1, q subcomponent-like 2

+

Mouse GeneAtlas

21357331

25672

18.9

5.1

Nr3c2

nuclear receptor subfamily 3, group C, member 2

+

Ratlas

21273900

24785

18.6

10.8

Slc9a4

solute carrier family 9, member 4

-

Ratlas

21372096

79247

17.9

11.2

Htr5b

5-hydroxytryptamine (serotonin) receptor 5B

+

Ratlas

20746536

rCG37048

17.6

6.8

unassigned

unassigned (similar to Potassium channel tetramerisation domain containing 4)

+

Mouse GeneAtlas

21740530

299757

17.3

27.4

Nts predicted

neurotensin (predicted)

-

Mouse GeneAtlas

21310693

54258

14.5

14.0

Il8ra

interleukin 8 receptor, alpha

+

Ratlas

21051913

288207

13.1

5.5

LOC288207

similar to Ephrin type-A receptor 6 precursor (Tyrosine-protein kinase receptor EHK-2)

+

Mouse GeneAtlas

Striatum

       

21655681

78974

46.3

68.1

Six3

sine oculis homeobox homolog 3 (Drosophila)

(+)

Mouse GeneAtlas

22132190

360616

37.4

19.8

Ppp1r1b

protein phosphatase 1, regulatory (inhibitor) subunit 1B

+

Mouse GeneAtlas

21997003

83683

32.8

43.4

Gpr6

G protein-coupled receptor 6

+

Ratlas

21480082

29237

31.7

14.7

Penk-rs

preproenkephalin, related sequence

+

Ratlas

21561963

24318

30.5

50.7

Drd2

dopamine receptor 2

+

Ratlas

21849263

24611

30.3

18.7

Gnal

guanine nucleotide binding protein, alpha stimulating, olfactory type

+

Ratlas

22158395

313445

29.2

8.0

Klhl13

kelch-like 13

+

Mouse GeneAtlas

22195704

24316

29.1

31.4

Drd1a

dopamine receptor 1A

+

Ratlas

22424342

308717

28.8

30.5

Slc35d3 predicted

solute carrier family 35, member D3 (predicted)

+

Mouse GeneAtlas

21577759

29481

28.7

46.7

Rgs9

regulator of G-protein signaling 9

+

Ratlas

Cerebellum

       

22368772

365008

58.5

38.8

LOC361412

similar to ADAMTS18

-

Mouse GeneAtlas

21761660

rCG56756

43.2

202.3

unassigned

unassigned

NA

No record

21883963

498922

38.5

134.3

LOC498922

similar to cerebellin 1 precursor protein

+

Mouse GeneAtlas

22259505

64618

37.8

49.5

Zic1

Zic family member 1 (odd-paired homolog, Drosophila) (HS)

+

Mouse GeneAtlas

21062179

498921

36.6

17.6

LOC498921

LOC498921

NA

No record

22187648

499964

35.9

273.3

LOC499964

similar to engrailed 2 protein

+

Mouse GeneAtlas

21989402

25509

32.6

17.7

Pax6

paired box gene 6 (TS)

+

Ratlas

21979738

287424

31.0

10.0

Aloxe3 predicted

arachidonate lipoxygenase 3 (predicted)

-

Mouse GeneAtlas

21212636

29458

30.0

58.1

Neurod1

neurogenic differentiation 1 (TS)

+

Ratlas

20988804

84012

28.5

51.3

Slc1a6

solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 (TS)

+

Ratlas

  1. a Celera ID for Celera exclusive genes, otherwise Entrez ID
  2. b Delta score: from SAM analysis (FDR = 0)
  3. c Fold: expression level of gene in a given region relative to the average expression in other CNS tissues.
  4. d Independent 'validation' of the regional enrichment is indicated, showing a '+' if a similar trend is detected by manual inspection in the SymAtlas (Human and Mouse GeneAtlas and Ratlas) [13, 14], otherwise showing a '-'.
  5. e Not applicable, no record of gene in expression database.