Table 4 Glutathione and methionine metabolism related genes are induced by the citrinin treatment
ORF-Array | Oligo-Array | ||||||
|---|---|---|---|---|---|---|---|
Systematic Name | Common Name | Average (Fold) | Fold | t-test P-value | Fold | t-test P-value | Description |
YKR069W | MET1 | 2.6 | 2.3 | 0.002 | 2.9 | 0.000 | siroheme synthase |
YFR030W | MET10 | 3.2 | 1.8 | 0.025 | 4.6 | 0.000 | sulfite reductase flavin-binding subunit |
YKL001C | MET14 | 5.2 | 5.3 | 0.000 | 5.1 | 0.000 | ATP adenosine-5^-phosphosulfate 3^-phosphotransferase |
YPR167C | MET16 | 5.1 | 5.6 | 0.001 | 4.6 | 0.000 | 3^-phosphoadenylylsulfate reductase |
YLR303W | MET17 | 14.7 | 12.3 | 0.000 | 17.1 | 0.000 | O-acetylhomoserine sulfhydrylase |
YNL277W | MET2 | 2.9 | 2.1 | 0.022 | 3.8 | 0.000 | homoserine O-acetyltransferase |
YOL064C | MET22 | 1.7 | 1.8 | 0.000 | 1.7 | 0.000 | protein ser/thr phosphatase |
YIR017C | MET28 | 4.7 | 2.0 | 0.198 | 7.5 | 0.000 | transcriptional activator of sulfur amino acid metabolism |
YJR010W | MET3 | 8.9 | 6.0 | 0.000 | 11.8 | 0.000 | sulfate adenylyltransferase |
YIL046W | MET30 | 1.1 | 1.2 | 0.203 | 1.1 | 0.147 | involved in regulation of sulfur assimilation genes |
YPL038W | MET31 | 1.0 | 1.2 | 0.151 | 0.9 | 0.004 | transcriptional regulator of sulfur amino acid metabolism |
YDR253C | MET32 | 2.7 | 2.2 | 0.004 | 3.3 | 0.000 | transcriptional regulator of sulfur amino acid metabolism |
YNL103W | MET4 | 1.0 | 0.7 | 0.102 | 1.2 | 0.001 | transcriptional activator of sulfur metabolism |
YER091C | MET6 | 2.7 | 2.6 | 0.001 | 2.7 | 0.000 | homocysteine methyltransferase |
YBR213W | MET8 | 1.4 | 1.2 | 0.460 | 1.6 | 0.000 | siroheme synthase |
YAL012W | CYS3 | 2.0 | 1.9 | 0.009 | 2.0 | 0.000 | cystathionine gamma-lyase |
YGR155W | CYS4 | 1.9 | 2.4 | 0.062 | 1.5 | 0.000 | cystathionine beta-synthase |
YJL101C | GSH1 | 2.4 | 2.2 | 0.000 | 2.7 | 0.000 | glutamate – cysteine ligase |
YOL049W | GSH2 | 1.1 | 0.9 | 0.064 | 1.2 | 0.000 | Glutathione synthetase |
YLR180W | SAM1 | 1.4 | 1.6 | 0.023 | 1.3 | 0.000 | S-adenosylmethionine synthetase 1 |
YDR502C | SAM2 | 1.6 | 1.5 | 0.000 | 1.6 | 0.000 | S-adenosylmethionine synthetase 2 |
YPL274W | SAM3 | 1.2 | 1.3 | 0.015 | 1.1 | 0.124 | S-adenosylmethionine permease |
YPL273W | SAM4 | 0.9 | 0.8 | 0.010 | 1.0 | 0.008 | AdoMet-homocysteine methyltransferase |
YJR130C | STR2 | 1.4 | 1.2 | NA | 1.6 | 0.000 | Cystathionine gamma-synthase |
YGL184C | STR3 | 2.1 | 1.4 | 0.367 | 2.9 | 0.001 | cystathionine beta-lyase |