Alignment of the 5'-flanking region of four mammalian HL genes . From the rat, mouse, macaque and human HL genes, exon-1 and 30 kb of upstream sequence was aligned by the MLAGAN algorithm of the mVista program. The sequences of rat (A), mouse (B) and macaque (C) are aligned to the human HL sequence (x-axis); numbering is relative to the transcriptional start site. Conserved regions (> 70% homology over 100 bp window) are shaded. The boxes indicate conserved regions among the four sequences, as determined by RankVista (P ≤ 10-5), with the P-values given above.