Figure 1

Pathway analysis based on the Ingenuity Pathway Knowledge Base (IPKB). The two highest scoring networks from the PRG list are shown. The shaded notes are genes from among the PRG list; colour shading corresponds to the type of deregulation, red for up-regulated genes, and green for down-regulated. White open nodes are not from among the 349 PRG list genes but are transcription factors that are associated with the regulation of some of these genes identified by IPKB. The shape of the node indicates the major function of the protein. A line denotes binding of the products of the two genes while a line with an arrow denotes 'acts on'. A dotted line denotes an indirect interaction and the orange lines indicate potential interaction with those transcription factors added by IPA that are not on the PRG list.