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Table 1 Comparison of the conserved G1, G2, G3, and G4 motifs of the mGBPs. The canonical GTP motifs of all mGBPs and the overall consensus sequence are shown. Amino acid substitutions are highlighted in bold.

From: Analyses of murine GBP homology clusters based on in silico, in vitro and in vivo studies

  G1 G2 G3 G4
mGBP1 GF YH TGKS T DTEG TL RD
mGBP2 GLYRTGKS T DTEG TL RD
mGBP3 GLYRTGKS T DTEG A VRD
mGBP4 GWSH TGKS - ---- ----
mGBP4.1 GWSH TGKS - DTEG TVRD
mGBP5 GLYRTGKS T DTEG TL RD
mGBP5.a GLYRTGKS - ---- TL RD
mGBP6 GLYRTGKS T DTEG TVRD
mGBP7 GLYRTGKS T DTEG TVRD
mGBP8 GLYRTGKS T DTEG TVRD
mGBP9 GLYRTGKS T DTEG TVRD
mGBP10 GWS RTGKS T DTEG I VRD
mGBP11 GLYRTGKS T DTEG TVRD
consensus GxxxTGKS T DTEG x(V/L)RD