Table 3 Genes with significantly altered expression in the STG in schizophrenia according to functional group.
From: Altered gene expression in the superior temporal gyrus in schizophrenia
Functional Group | GenBank ID | Name | Symbol | Cytoband | # pairs changed/7 | Average Fold Change |
|---|---|---|---|---|---|---|
Neuro- transmission | NM_000834 | Glutamate receptor, ionotropic, N-methyl D-aspartate 2B | GRIN2B | 12p12 | 4 | 1.98 |
| Â | AL157442 | Glutamate receptor, ionotropic, N-methyl D-asparate-associated protein 1 (glutamate binding) | GRINA | 8q24.3 | 6 | -2.33 |
| Â | AK024507 | Glutamate receptor interacting protein 2 | GRIP2 | 3p24-p23 | 4 | -1.73 |
| Â | AB043997 | Solute carrier family 5 (choline transporter), member 7 | SLC5A7 | 2q12 | 5 | 2.07 |
|  | AF263613 | Intracellular membrane-associated calcium-independent phospholipase A2 gamma* | IPLA2(γ) | 7q31 | 6 | 1.88 |
| Â | AF311862 | Lin-7 homolog B (C. elegans) | LIN7B | 19q13.3 | 6 | -3.00 |
| Â | AL137559 | Synaptotagmin VII | SYT7 | 11q12-q13.1 | 4 | -1.90 |
| Â | NM_007232 | Histamine receptor H3 | HRH3 | 20q13.33 | 4 | -2.00 |
Presynaptic function | AJ132089 | Dynein, axonemal, heavy polypeptide 10 | DNAH10 | 12q24.31 | 6 | 4.08 |
| Â | AB011131 | Piccolo* | PCLO | 7q11.23-q21.3 | 4 | -2.23 |
Myelination | AF179481 | Acyl-CoA synthetase bubblegum family member 1* | Ascbg1 | 15q23-q24 | 5 | -1.94 |
Neuro- development | AL050059 | Disabled homolog 1 (Drosophila) | DAB1 | 1p32-p31 | 4 | -2.49 |
| Â | NM_006885 | AT-binding transcription factor 1 | ATBF1 | 16q22.3-q23.1 | 6 | 2.77 |
| Â | NM_006156 | Neural precursor cell expressed, developmentally down-regulated 8 | NEDD8 | 14q11.2 | 5 | -2.62 |
| Â | AF087991 | Netrin G1 | NTNG1 | 1p13.3 | 5 | -2.57 |
| Â | AF009311 | Semaphorin 5A | SEMA5A | 5p15.2 | 4 | 2.23 |
Intracellular signalling | M61906 | Phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha) | PIK3R1 | 5q13.1 | 7 | 4.10 |
| Â | NM_003632 | Contactin associated protein 1 | CNTNAP1 | 17q21 | 4 | -2.74 |
| Â | NM_006078 | Calcium channel, voltage-dependent, gamma subunit 2 | CACNG2 | 22q13.1 | 4 | -2.16 |
| Â | NM_003385 | Visinin-like 1 | VSNL1 | 2p24.3 | 5 | -2.15 |
| Â | NM_005031 | FXYD domain containing ion transport regulator 1 (phospholemman)* | FXYD1 | 19q13.1 | 5 | -3.07 |
Other brain related illnesses | NM_005503 | Amyloid beta (A4) precursor protein-binding, family A, member 2 (X11-like) | APBA2 | 15q11-q12 | 4 | -2.55 |
|  | NM_004860 | Fragile × mental retardation, autosomal homolog 2 | FXR2 | 17p13.1 | 5 | -2.16 |
Other functions | AB002340 | Lupus brain antigen 1 | LBA1 | 3p22.3 | 4 | -1.89 |
| Â | NM_002629 | Phosphoglycerate mutase 1 (brain) | PGAM1 | 10q25.3 | 4 | -2.18 |
| Â | NM_016223 | Protein kinase C and casein kinase substrate in neurons 3 | PACSIN3 | 11p12-p11.12 | 5 | -2.22 |
| Â | NM_005619 | Reticulon 2 | RTN2 | 19q13.32 | 4 | -1.72 |
| Â | NM_001048 | Somatostatin | SST | 3q28 | 5 | -3.02 |
| Â | U27768 | Regulator of G-protein signalling 4* | RGS4 | 1q23.3 | 4 | -1.79 |
| Â | M96577 | E2F transcription factor 1 | E2F1 | 20q11.2 | 6 | -2.59 |
| Â | AK023573 | Synapse defective 1, Rho GTPase, homolog 1 (C. elegans) | 7h3 | 19p13.12 | 4 | -1.71 |
| Â | X87825 | Olfactory receptor, family 7, subfamily E, member 47 pseudogene | OR7E47P | 12q13.13 | 6 | 7.32 |
| Â | X89668 | Olfactory receptor, family 7, subfamily E, member 19 pseudogene | OR7E19P | 19p13.2 | 7 | 2.23 |