Evolutionary rates and patterns for human transcription factor binding sites derived from repetitive DNA

BMC Genomics

Table 3 Position-specific sequence variation scores for TE-derived, non-repetitive, matrix-random and genome-random TFBS.

Matrix¹	Protein binding factor²	TE-derived	non-repetitive	matrix-rand	genome-rand	repeat-rand
M00671	T-cell-specific transcription factor 4 (TCF-4 or TCF7L2)	4.25	5.69 ± 0.51	5.80 ± 0.73	-48.76 ± 15.61	-48.63 ± 14.97
M00761	p53 (TP53)	5.97	6.65 ± 1.26	5.52 ± 1.92	-2.79 ± 3.02	-4.71 ± 3.35
M00789	GATA binding proteins (GATA)	6.12	5.26 ± 1.56	5.27 ± 1.46	-5.87 ± 2.71	-4.70 ± 3.15
M00962	Androgen receptor (AR)	3.72	4.45 ± 1.21	4.33 ± 1.74	-2.29 ± 1.28	-1.80 ± 2.17
M01037	Glioma-associated oncogene homolog 1 (GLI1)	9.34	9.12 ± 1.14	9.24 ± 1.70	1.77 ± 2.83	-4.28 ± 2.91

Average TFBS scores are shown for each category of sites.
¹The TRANSFAC database matrix identifier
²The colloquial name of the protein that binds the TFBS along with its official HUGO name in parentheses

ISSN: 1471-2164