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Table 3 Genes differentially expressed in Leishmania infantum but constitutively expressed in Leishmania major.

From: Genome-wide gene expression profiling analysis of Leishmania major and Leishmania infantum developmental stages reveals substantial differences between the two species

GO annotation (molecular function) Accession number (GeneDB) Fold increase Accession number (GeneDB) Fold increasea
  L. infantum   L. major  
Metabolic process
glycerolphosphate mutase LinJ33_V3.2220 2,2 b LmjF33.2100 1,4
iron superoxide dismutase LinJ32_V3.1920 1,9 b LmjF32.1839 1,2
proteasome alpha 7 subunit LinJ27_V3.0190 1,9 b LmjF27.0190 1,3
pyruvate phosphate dikinase LinJ11_V3.1000 1,8 b LmjF11.1000 1,3
nuclear receptor binding factor-like protein LinJ05_V3.0520 2,1 c LmjF05.0520 1,3
quinone oxidoreductase LinJ03_V3.0550 11,7 c LmjF03.0570 1,0
quinonoid dihydropteridine reductase LinJ34_V3.4270 20,2 c LmjF34.4330 1,0
Response to oxidative stress
ascorbate-dependent peroxidase LinJ34_V3.0070 3,0 b LmjF34.0070 1,6
Carbohydrate metabolic process
6-phosphogluconate dehydrogenase, decarboxylating LinJ35_V3.3390 2,0 b LmjF35.3340 1,0
pyruvate kinase LinJ35_V3.5450 1,9 b LmjF35.0030 1,4
Nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
thymidine kinase LinJ21_V3.1450 1,7 b LmjF21.1210 1,3
DNA-directed RNA polymerase, alpha subunit LinJ19_V3.0660 1,9 c LmjF19.0660 1,0
nuclear cap binding protein LinJ30_V3.0560 4,1 c LmjF30.0540 1,1
vacuolar ATP synthase subunit LinJ12_V3.0480 1,7 c LmjF12.0520 1,0
DNA metabolic process
kinetoplast DNA-associated protein LinJ36_V3.6180 1,8 b LmjF36.5920 1,1
RNA metabolic process
RNA binding protein LinJ04_V3.1190 2,2 b LmjF04.1170 1,0
RNA binding protein UBP1 LinJ25_V3.0500 2,1 b LmjF25.0490 1,1
RNA binding protein UBP2 LinJ25_V3.0510 2,1 b LmjF25.0500 1,1
mRNA capping methyltransferase LinJ36_V3.0130 7,3 c LmjF36.0120 1,1
pseudouridylate synthase-like LinJ01_V3.0280 1,9 c LmjF01.0280 1,1
RNA-binding protein LinJ17_V3.0610 1,7 c LmjF17.0550 1,3
RNase PH-like exosome associated protein 1 LinJ20_V3.1400 2,0 c LmjF20.1360 1,1
Amino acid and derivative metabolic process
glycine dehydrogenase LinJ26_V3.0040 8,1 c LmjF26.0030 1,4
Protein metabolic process
Proteolysis
mitochondrial processing peptidase, beta subunit LinJ35_V3.1390 2,1 b LmjF35.1380 1,0
aminopeptidase LinJ19_V3.0150 1,7 c LmjF19.0160 1,2
aminopeptidase LinJ33_V3.2700 4,7 c LmjF33.2570 1,3
mitochondrial ATP-dependent zinc metallopeptidase LinJ34_V3.1130 3,6 c LmjF34.1060 1,1
Protein folding
chaperone protein DNAJ LinJ18_V3.1470 1,8 c LmjF18.1490 1,1
DNAJ protein LinJ21_V3.0550 4,5 c LmjF21.0490 1,0
Protein modification process
protein kinase LinJ27_V3.0100 4,6 c LmjF27.0100 1,0
Electron transport
oxidoreductase-like protein LinJ19_V3.1490 1,7 b LmjF19.1450 1,0
trypanothione reductase LinJ05_V3.0350 1,7 b LmjF05.0350 1,1
Transport
mitochondrial carrier protein LinJ35_V3.3380 1,8 b LmjF35.3330 1,5
  LinJ28_V3.2050,    
zinc transporter LinJ28_V3.2060 2,5 b LmjF28.1930 1,2
ABC transporter LinJ29_V3.0640 4,8 c LmjF29.0620 1,6
ABC transporter LinJ11_V3.0040 10,9 c LmjF11.0040 1,3
amino acid permease LinJ36_V3.0450 30,9 c LmjF36.0420 1,4
pteridine transporter LinJ06_V3.1320 2,8 c LmjF06.1260 1,6
Cellular component organization and biogenesis
  LinJ16._V3.1550,    
kinesin LinJ16_V3.1570 1,8 b LmjF16.1460 1,0
kinesin LinJ23_V3.0720 1,9 b LmjF23.0560 1,1
kinesin LinJ25_V3.2050 3,8 c LmjF25.1970 1,1
Cell cycle
cyclin-dependent kinase regulatory subunit LinJ32_V3.3940 1,7 c LmjF32.3790 1,0
Cell communication
phosphoinositide-binding protein LinJ35_V3.2470 1,9 b LmjF35.2420 1,2
rab11B GTPase LinJ32_V3.1930 1,8 b LmjF32.1840 1,1
Unclassified
hypothetical LinJ02_V3.0430 4,3 b LmjF02.0460 1,4
hypothetical LinJ19_V3.0570 1,8 b LmjF19.0540 1,3
hypothetical LinJ19_V3.0610 1,8 b LmjF19.0610 1,1
hypothetical LinJ19_V3.1150 1,9 b LmjF19.1160 1,2
hypothetical LinJ20_V3.0030 3,6 b LmjF20.0030 1,1
hypothetical LinJ23_V3.0010 2,1 b LmjF23.0010 1,6
hypothetical LinJ23_V3.1170 2,2 b LmjF23.1000 1,3
hypothetical LinJ24_V3.2420 1,8 b LmjF24.2330 1,2
hypothetical LinJ27_V3.1110 2,5 b LmjF27.1230 1,3
hypothetical LinJ28_V3.0100 1,8 b LmjF28.0100 1,3
hypothetical LinJ32_V3.0530 1,7 b LmjF32.0500 1,3
hypothetical LinJ33_V3.1200 2,6 b LmjF33.1140 1,1
hypothetical LinJ33_V3.2570 1,8 b LmjF33.2440 1,0
hypothetical LinJ35_V3.0180 1,8 b LmjF35.0180 1,3
hypothetical LinJ35_V3.4360 1,7 b LmjF35.4290 1,2
hypothetical LinJ36_V3.5520 2,9 b LmjF36.5290 1,1
A-1 LinJ29_V3.1020 2,4 c LmjF29.0935 1,6
dehydrogenase/oxidoreductase-like protein LinJ02_V3.0700 2,0 c LmjF02.0730 1,2
EF hand-like protein LinJ13_V3.1490 1,9 c LmjF13.1450 1,3
ferric reductase transmembrane protein LinJ30_V3.2050 2,0 c LmjF30.2050 1,2
GTPase activator protein LinJ29_V3.1670 7,1 c LmjF29.1560 1,1
leucine rich repeat protein LinJ28_V3.2790 5,5 c LmjF28.2580 1,0
lipin LinJ06_V3.0860 1,8 c LmjF06.0830 1,0
membrane-bound acid phosphatase LinJ28_V3.2850 2,2 c LmjF28.2650 1,4
zinc-finger protein LinJ30_V3.2350 2,4 c LmjF30.2340 1,1
metallopeptidase LinJ16_V3.0850 8,9 c LmjF16.0850 1,3
hypothetical LinJ01_V3.0820 2,3 c LmjF01.0800 1,0
hypothetical LinJ03_V3.0060 3,0 c LmjF03.0070 1,3
hypothetical LinJ04_V3.1150 7,7 c LmjF04.1140 1,3
hypothetical LinJ07_V3.0390 2,1 c LmjF07.0230 1,2
hypothetical LinJ08_V3.0170 1,9 c LmjF08.0160 1,1
hypothetical LinJ12_V3.0710 1,8 c LmjF12.1110 1,3
hypothetical LinJ13_V3.0230 2,7 c LmjF13.0230 1,2
hypothetical LinJ14_V3.0560 24,6 c LmjF14.0550 1,4
hypothetical LinJ15_V3.0510 8,5 c LmjF15.0490 1,0
hypothetical LinJ15_V3.1000 4,7 c LmjF15.0940 1,0
hypothetical LinJ16_V3.0620 5,2 c LmjF16.0620 1,3
hypothetical LinJ16_V3.1260 11,6 c LmjF16.1210 1,1
hypothetical LinJ17_V3.0600 2,4 c LmjF17.0540 1,1
hypothetical LinJ18_V3.0120 1,9 c LmjF18.0120 1,1
hypothetical LinJ18_V3.0300 3,0 c LmjF18.0300 1,1
hypothetical LinJ19_V3.1170 9,0 c LmjF19.1180 1,4
hypothetical LinJ20_V3.0450 1,8 c LmjF20.0380 1,1
hypothetical LinJ20_V3.1670 3,3 c LmjF20.1700 1,4
hypothetical LinJ21_V3.0920 4,6 c LmjF21.0825 1,1
hypothetical LinJ21_V3.1220 5,1 c LmjF21.0980 1,3
hypothetical LinJ22_V3.0110 1,8 c LmjF22.0240 1,2
hypothetical LinJ23_V3.1520 2,3 c LmjF23.1267 1,1
hypothetical LinJ24_V3.0700 8,2 c LmjF24.0690 1,5
hypothetical LinJ24_V3.1080 4,0 c LmjF24.1060 1,1
hypothetical LinJ24_V3.1620 1,9 c LmjF24.1550 1,1
hypothetical LinJ25_V3.0220 11,0 c LmjF25.0220 1,2
hypothetical LinJ25_V3.0460 5,0 c LmjF25.0450 1,4
hypothetical LinJ25_V3.0560 32,7 c LmjF25.0550 1,1
hypothetical LinJ26_V3.1260 1,9 c LmjF26.1280 1,0
hypothetical LinJ26_V3.1850 2,8 c LmjF26.1850 1,1
hypothetical LinJ26_V3.2220 6,5 c LmjF26.2210 1,2
hypothetical LinJ27_V3.1080 2,8 c LmjF27.1200 1,1
hypothetical LinJ29_V3.0930 46,7 c LmjF29.0868 1,5
hypothetical LinJ30_V3.0160 12,4 c LmjF30.0170 1,2
hypothetical LinJ31_V3.0490 5,4 c LmjF31.0470 1,3
hypothetical LinJ31_V3.1630 2,2 c LmjF31.1600 1,0
hypothetical LinJ32_V3.1410 2,2 c LmjF32.1350 1,1
hypothetical LinJ32_V3.3760 2,9 c LmjF32.3600 1,2
hypothetical LinJ33_V3.0590 1,8 c LmjF33.0565 1,3
hypothetical LinJ33_V3.0810 2,1 c LmjF33.0760 1,1
hypothetical LinJ33_V3.2850 1,9 c LmjF33.2710 1,4
hypothetical LinJ34_V3.2250 2,0 c LmjF34.2473 1,2
hypothetical LinJ34_V3.3520 4,1 c LmjF34.3730 1,1
hypothetical LinJ35_V3.4090 10,3 c LmjF35.4040 1,2
hypothetical LinJ35_V3.1640 9,4 c LmjF35.1640 1,2
hypothetical LinJ35_V3.5350 2,1 c LmjF35.5030 1,0
hypothetical LinJ36_V3.0470 6,3 c LmjF36.0440 1,1
hypothetical LinJ36_V3.4410 3,5 c LmjF36.4200 1,6
hypothetical LinJ36_V3.4940 1,8 c LmjF36.4710 1,1
  1. a Only non-modulated genes are listed in this column.
  2. b Genes differentially expressed in promastigotes.
  3. c Genes differentially expressed in amastigotes.