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Table 4 Genes differentially expressed in Leishmania major but constitutively expressed in Leishmania infantum.

From: Genome-wide gene expression profiling analysis of Leishmania major and Leishmania infantum developmental stages reveals substantial differences between the two species

GO annotation (molecular function) Accession number (GeneDB) Fold increasea Accession number (GeneDB) Fold increase
  L. infantum   L. major  
Metabolic process
2-aminoethylphosphonate: pyruvateaminotransferase LinJ03_V3.0400 1,0 LmjF03.0040 2,0 b
folylpolyglutamate synthetase LinJ36_V3.2740 1,1 LmjF36.2610 2,1 b
phosphatidylethanolaminen-methyltransferase LinJ31_V3.3250 1,3 LmjF31.3120 2,4 b
aldehyde dehydrogenase LinJ25_V3.1160 1,1 LmjF25.1120 3,7 c
arginase LinJ35_V3.1490 1,3 LmjF35.1480 2,8 c
Carbohydrate metabolic process
6-phospho-1-fructokinase LinJ29_V3.2620 1,4 LmjF29.2510 2,6 b
aldose 1-epimerase LinJ35_V3.0990 1,1 LmjF35.0970 3,2 b
beta-fructofuranosidase LinJ04_V3.0300 1,3 LmjF04.0310 5,4 b
beta-fructofuranosidase LinJ04_V3.0310 1,2 LmjF04.0320 3,6 b
  LinJ35_V3.0640,    
beta-fructofuranosidase LinJ35_V3.0650 1,6 LmjF35.0640 5,9 b
  LinJ21_V3.0300,   LmjF21.0240,  
hexokinase LinJ21_V3.0310 1,2 LmjF21.0250 2,2 b
glyceraldehyde 3-phosphate dehydrogenase LinJ36_V3.2480 1,4 LmjF36.2350 3,6 c
Lipid metabolic process
farnesyl pyrophosphate synthase LinJ22_V3.1210 1,2 LmjF22.1360 1,9 b
fatty acid elongase LinJ14_V3.0670 1,6 LmjF14.0650 2,7 b
mevalonate kinase LinJ31_V3.0580 1,1 LmjF31.0560 2,1 b
phospholipase c-like LinJ30_V3.2970 1,3 LmjF30.2950 2,1 c
polyprenyl synthase LinJ19_V3.0210 1,0 LmjF19.0220 2,4 c
Nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
adenosine deaminase LinJ35_V3.2200 1,1 LmjF35.2160 4,6 b
DNA metabolic process
j-binding protein LinJ14_V3.0040 1,4 LmjF14.0040 2,3 b
RNA metabolic process
RNA-binding protein LinJ23_V3.0900 1,3 LmjF23.0730 3,6 c
Amino acid and derivative metabolic process
tyrosine aminotransferase LinJ36_V3.2490 1,1 LmjF36.2360 2,7 b
Protein metabolic process
lipophosphoglycan biosynthetic protein LinJ29_V3.0790 1,3 LmjF29.0760 2,3 b
Proteolysis
calpain-like cysteine peptidase LinJ20_V3.1230 1,1 LmjF20.1190 2,6 b
calpain-like cysteine peptidase LinJ27_V3.0510 1,3 LmjF27.0510 2,8 b
carboxypeptidase LinJ33_V3.2670 1,6 LmjF33.2540 3,0 b
carboxypeptidase LinJ13_V3.0090 1,1 LmjF13.0090 2,1 b
glutamamyl carboxypeptidase LinJ29_V3.1680 1,1 LmjF29.1570 1,7 b
oligopeptidase b LinJ09_V3.0820 1,1 LmjF09.0770 2,2 b
pyroglutamyl-peptidase (PGP) LinJ34_V3.1750 1,4 LmjF34.2000 2,0 b
cysteine protease LinJ19_V3.1460 1,3 LmjF19.1420 3,1 c
Protein folding
chaperone protein DNAJ LinJ32_V3.3220 1,1 LmjF32.3030 2,2 b
Protein modification process
protein kinase LinJ26_V3.2600 1,2 LmjF26.2570 4,3 b
protein kinase LinJ21_V3.0190 1,1 LmjF21.0130 2,2 b
mitogen-activated protein kinase 3 LinJ10_V3.0540 1,0 LmjF10.0490 2,0 b
serine/threonine-protein kinase LinJ31_V3.3070 1,1 LmjF31.2960 2,8 b
serine/threonine-protein phosphatase PP1 LinJ34_V3.0850 1,1 LmjF34.0810 1,8 b
protein kinase LinJ36_V3.4460 1,6 LmjF36.4250 1,7 c
Electron transport
D-lactate dehydrogenase LinJ29_V3.0290 1,1 LmjF29.0280 3,0 b
pyrroline-5-carboxylate reductase LinJ13_V3.1420 1,6 LmjF13.1680 2,1 b
UDP-galactopyranose LinJ18_V3.0200 1,1 LmjF18.0200 1,7 b
Transport
amino acid permease LinJ27_V3.0530 1,6 LmjF27.0680 3,0 b
biopterin transporter LinJ35_V3.5120 1,1 LmjF35.5150 2,4 b
    LmjF36.6280,  
glucose transporter, lmgt2 LinJ36_V3.6550 1,0 LmjF36.6290 5,6 b
pteridine transporter LinJ06_V3.0310 1,1 LmjF06.0310 3,2 b
sugar transporter LinJ24_V3.0690 1,0 LmjF24.0680 3,9 b
transmembrane amino acid transporter LinJ07_V3.1340 1,1 LmjF07.1160 9,7 b
  LinJ15_V3.1230,    
  LinJ15_V3.1240,    
  LinJ15_V3.1250,   LmjF15.1230,  
nucleoside transporter 1 LinJ15_V3.1260 1,2 LmjF15.1240 4,5 b
mitochondrial ornithine transporter 1-like LinJ16_V3.0220 1,0 LmjF16.0210 2,2 b
Cell component organization and biogenesis
dynein heavy chain LinJ36_V3.1010 1,6 LmjF36.0950 2,6 b
kinesin LinJ14_V3.0870 1,1 LmjF14.0810 1,8 b
kinesin LinJ21_V3.1280 1,4 LmjF21.1040 1,9 b
    LmjF09.0150,  
    LmjF09.0154,  
    LmjF09.0158,  
    LmjF09.0162,  
    LmjF09.0166,  
    LmjF09.0170,  
microtubule associated protein LinJ09_V3.0180 1,3 LmjF09.0174 2,5 b
  LinJ19_V3.0820,    
microtubule associated protein LinJ19_V3.0850 1,1 LmjF19.0860 2,5 b
PFR LinJ05_V3.0920 1,3 LmjF05.0920 2,3 b
PFR par4 LinJ05_V3.0040 1,3 LmjF05.0040 2,8 b
Cell communication
cAMP specific phosphodiesterase LinJ15_V3.1550 1,5 LmjF15.1480 1,8 b
phosphodiesterase LinJ18_V3.1100 1,4 LmjF18.1090 2,3 b
Cell motility
myosin heavy chain LinJ32_V3.4020 1,6 LmjF32.3870 3,5 b
Unclassified
acid phophatase LinJ36_V3.2600 1,0 LmjF36.2470 1,9 b
long chain fatty Acyl CoA synthetase LinJ03_V3.0220 1,1 LmjF03.0230 1,9 b
  LinJ19_V3.1350,   LmjF19.1340,  
glycerol uptake protein LinJ19_V3.1360 1,3 LmjF19.1345 1,8 b
membrane-bound acid phosphatase 2 LinJ36_V3.2720 1,1 LmjF36.2590 4,6 b
nons pecific nucleoside hydrolas e LinJ18_V3.1570 1,1 LmjF18.1580 2,1 b
prostaglandin f2-alpha synthase LinJ31_V3.2210 1,5 LmjF31.2150 5,1 b
  LinJ31_V3.0950,   Lm jF 31.0920,  
s odium s tibogluconate res is tance protein LinJ31_V3.3400 1,4 LmjF31.0950 2,1 b
s urfac e antigen-lik e LinJ04_V3.0170 1,0 Lm jF04.0180 2,0 b
s urfac e antigen-lik e LinJ04_V3.0180 1,0 Lm jF04.0190 2,7 b
    Lm jF 12.0850,  
    Lm jF 12.0860,  
    Lm jF 12.0870,  
surface antigen 2 LinJ12_V3.0020 1,2 LmjF12.0890 2,1 b
ubiquitin-conjugating enzy me-like LinJ21_V3.0500 1,6 Lm jF21.0440 2,2 b
hypothetical LinJ03_V3.0340 1,4 Lm jF03.0360 1,9 b
    Lm jF 04.0130,  
    Lm jF 04.0140,  
    Lm jF 04.0150,  
    Lm jF 04.0160,  
hypothetical LinJ04_V3.0160 1,1 LmjF04.0170 2,9 b
hypothetical LinJ05_V3.1070 1,3 Lm jF05.1070 3,0 b
hypothetical LinJ09_V3.1360 1,0 Lm jF09.1300 2,0 b
hypothetical LinJ09_V3.1600 1,4 Lm jF09.1510 2,9 b
hypothetical LinJ09_V3.1610 1,1 Lm jF09.1520 3,2 b
    Lm jF 11.0670,  
  LinJ11_V3.0680,   Lm jF 11.0673,  
hypothetical LinJ11_V3.0690 1,0 LmjF11.0675 3,0 b
hypothetical LinJ04_V3.1220 1,3 Lm jF04.1200 2,0 b
  LinJ14_V3.0490,   Lm jF 14.0480,  
hypothetical LinJ14_V3.0500 1,3 LmjF14.0490 2,6 b
hypothetical LinJ15_V3.0560 1,0 Lm jF15.0540 1,9 b
hypothetical LinJ17_V3.0690 1,4 Lm jF17.0630 2,5 b
hypothetical LinJ17_V3.0990 1,1 Lm jF17.0890 6,5 b
hypothetical LinJ18_V3.1300 1,1 Lm jF18.1320 1,9 b
hypothetical LinJ19_V3.0070 1,4 Lm jF19.0080 3,5 b
hypothetical LinJ23_V3.0890 1,3 Lm jF23.0720 2,4 b
hypothetical LinJ23_V3.1020 1,1 Lm jF23.0840 2,6 b
hypothetical LinJ23_V3.1730 1,4 Lm jF23.1690 1,8 b
hypothetical LinJ24_V3.1110 1,1 Lm jF24.1090 4,6 b
hypothetical LinJ25_V3.2090 1,1 Lm jF25.2010 2,7 b
hypothetical LinJ26_V3.1980 1,5 Lm jF26.1980 1,9 b
hypothetical LinJ28_V3.0220 1,1 LmjF28.0220 1,7 b
hypothetical LinJ28_V3.0420 1,2 LmjF28.0280 1,8 b
hypothetical LinJ29_V3.1820 1,0 Lm jF29.1690 2,8 b
hypothetical LinJ29_V3.2550 1,6 Lm jF29.2440 3,3 b
hypothetical LinJ30_V3.1230 1,1 Lm jF30.1170 2,5 b
hypothetical LinJ30_V3.2700 1,3 Lm jF30.2700 3,3 b
hypothetical LinJ32_V3.0480 1,3 LmjF32.0470 2,0 b
hypothetical LinJ32_V3.1760 1,4 Lm jF32.1680 3,3 b
hypothetical LinJ32_V3.3350 1,3 Lm jF32.3150 2,3 b
hypothetical LinJ32_V3.3650 1,3 Lm jF32.3450 1,9 b
hypothetical LinJ33_V3.0220 1,6 Lm jF33.0210 4,0 b
hypothetical LinJ33_V3.1040 1,0 Lm jF33.0990 3,4 b
hypothetical LinJ33_V3.1130 1,4 LmjF33.1070 2,7 b
hypothetical LinJ33_V3.2940 1,4 LmjF33.2800 1,7 b
hypothetical LinJ34_V3.0210 1,1 LmjF34.0190 2,1 b
hypothetical LinJ34_V3.0740 1,2 LmjF34.0705 1,8 b
hypothetical LinJ34_V3.4110 1,0 LmjF34.4280 2,4 b
hypothetical LinJ35_V3.1470 1,0 LmjF35.1460 1,7 b
hypothetical LinJ35_V3.5400 1,2 LmjF35.5080 1,7 b
hypothetical LinJ36_V3.0730 1,0 LmjF36.0670 2,5 b
hypothetical LinJ36_V3.1190 1,0 LmjF36.1130 1,7 b
hypothetical LinJ36_V3.1230 1,3 LmjF36.1170 2,1 b
hypothetical LinJ36_V3.1520 1,1 LmjF36.1460 1,7 b
hypothetical LinJ36_V3.4470 1,1 LmjF36.4260 2,0 b
    Lm jF30.1410,  
    Lm jF30.1420,  
ama 1 LinJ30_V3.1490 1,1 LmjF30.1430 2,1 c
    Lm jF31.1450,  
s urfac e membrane protein gp46-like LinJ31_V3.1490 1,1 LmjF31.1460 2,1 c
hypothetical LinJ06_V3.0030 1,1 LmjF06.0030 2,0 c
hypothetical LinJ17_V3.0390 1,3 LmjF17.0340 4,0 c
hypothetical LinJ18_V3.1110 1,1 LmjF18.1100 1,7 c
hypothetical LinJ19_V3.1540 1,1 LmjF19.1490 1,8 c
hypothetical LinJ20_V3.1630 1,1 LmjF20.1660 2,0 c
hypothetical LinJ24_V3.0590 1,2 LmjF24.0580 4,8 c
hypothetical LinJ25_V3.0230 1,3 LmjF25.0230 2,0 c
hypothetical LinJ26_V3.1500 1,3 LmjF26.1520 3,5 c
hypothetical LinJ28_V3.1070 1,4 LmjF28.0980 2,6 c
hypothetical LinJ28_V3.2860 1,2 LmjF28.2660 2,0 c
hypothetical LinJ31_V3.2910 1,4 LmjF31.2810 2,1 c
hypothetical LinJ32_V3.2620 1,3 LmjF32.2480 1,8 c
hypothetical LinJ35_V3.4870 1,3 LmjF35.4810 1,8 c
hypothetical LinJ36_V3.2960 1,1 LmjF36.2820 1,9 c
hypothetical LinJ36_V3.3480 1,3 LmjF36.3320 1,7 c
hypothetical LinJ36_V3.4870 1,0 LmjF36.4640 2,0 c
  1. a Only non-modulated genes are listed in this column.
  2. b Genes differentially expressed in promastigotes.
  3. c Genes differentially expressed in amastigotes.