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Table 4 Genes differentially expressed in Leishmania major but constitutively expressed in Leishmania infantum.

From: Genome-wide gene expression profiling analysis of Leishmania major and Leishmania infantum developmental stages reveals substantial differences between the two species

GO annotation (molecular function)

Accession number (GeneDB)

Fold increasea

Accession number (GeneDB)

Fold increase

 

L. infantum

 

L. major

 

Metabolic process

2-aminoethylphosphonate: pyruvateaminotransferase

LinJ03_V3.0400

1,0

LmjF03.0040

2,0 b

folylpolyglutamate synthetase

LinJ36_V3.2740

1,1

LmjF36.2610

2,1 b

phosphatidylethanolaminen-methyltransferase

LinJ31_V3.3250

1,3

LmjF31.3120

2,4 b

aldehyde dehydrogenase

LinJ25_V3.1160

1,1

LmjF25.1120

3,7 c

arginase

LinJ35_V3.1490

1,3

LmjF35.1480

2,8 c

Carbohydrate metabolic process

6-phospho-1-fructokinase

LinJ29_V3.2620

1,4

LmjF29.2510

2,6 b

aldose 1-epimerase

LinJ35_V3.0990

1,1

LmjF35.0970

3,2 b

beta-fructofuranosidase

LinJ04_V3.0300

1,3

LmjF04.0310

5,4 b

beta-fructofuranosidase

LinJ04_V3.0310

1,2

LmjF04.0320

3,6 b

 

LinJ35_V3.0640,

   

beta-fructofuranosidase

LinJ35_V3.0650

1,6

LmjF35.0640

5,9 b

 

LinJ21_V3.0300,

 

LmjF21.0240,

 

hexokinase

LinJ21_V3.0310

1,2

LmjF21.0250

2,2 b

glyceraldehyde 3-phosphate dehydrogenase

LinJ36_V3.2480

1,4

LmjF36.2350

3,6 c

Lipid metabolic process

farnesyl pyrophosphate synthase

LinJ22_V3.1210

1,2

LmjF22.1360

1,9 b

fatty acid elongase

LinJ14_V3.0670

1,6

LmjF14.0650

2,7 b

mevalonate kinase

LinJ31_V3.0580

1,1

LmjF31.0560

2,1 b

phospholipase c-like

LinJ30_V3.2970

1,3

LmjF30.2950

2,1 c

polyprenyl synthase

LinJ19_V3.0210

1,0

LmjF19.0220

2,4 c

Nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

adenosine deaminase

LinJ35_V3.2200

1,1

LmjF35.2160

4,6 b

DNA metabolic process

j-binding protein

LinJ14_V3.0040

1,4

LmjF14.0040

2,3 b

RNA metabolic process

RNA-binding protein

LinJ23_V3.0900

1,3

LmjF23.0730

3,6 c

Amino acid and derivative metabolic process

tyrosine aminotransferase

LinJ36_V3.2490

1,1

LmjF36.2360

2,7 b

Protein metabolic process

lipophosphoglycan biosynthetic protein

LinJ29_V3.0790

1,3

LmjF29.0760

2,3 b

Proteolysis

calpain-like cysteine peptidase

LinJ20_V3.1230

1,1

LmjF20.1190

2,6 b

calpain-like cysteine peptidase

LinJ27_V3.0510

1,3

LmjF27.0510

2,8 b

carboxypeptidase

LinJ33_V3.2670

1,6

LmjF33.2540

3,0 b

carboxypeptidase

LinJ13_V3.0090

1,1

LmjF13.0090

2,1 b

glutamamyl carboxypeptidase

LinJ29_V3.1680

1,1

LmjF29.1570

1,7 b

oligopeptidase b

LinJ09_V3.0820

1,1

LmjF09.0770

2,2 b

pyroglutamyl-peptidase (PGP)

LinJ34_V3.1750

1,4

LmjF34.2000

2,0 b

cysteine protease

LinJ19_V3.1460

1,3

LmjF19.1420

3,1 c

Protein folding

chaperone protein DNAJ

LinJ32_V3.3220

1,1

LmjF32.3030

2,2 b

Protein modification process

protein kinase

LinJ26_V3.2600

1,2

LmjF26.2570

4,3 b

protein kinase

LinJ21_V3.0190

1,1

LmjF21.0130

2,2 b

mitogen-activated protein kinase 3

LinJ10_V3.0540

1,0

LmjF10.0490

2,0 b

serine/threonine-protein kinase

LinJ31_V3.3070

1,1

LmjF31.2960

2,8 b

serine/threonine-protein phosphatase PP1

LinJ34_V3.0850

1,1

LmjF34.0810

1,8 b

protein kinase

LinJ36_V3.4460

1,6

LmjF36.4250

1,7 c

Electron transport

D-lactate dehydrogenase

LinJ29_V3.0290

1,1

LmjF29.0280

3,0 b

pyrroline-5-carboxylate reductase

LinJ13_V3.1420

1,6

LmjF13.1680

2,1 b

UDP-galactopyranose

LinJ18_V3.0200

1,1

LmjF18.0200

1,7 b

Transport

amino acid permease

LinJ27_V3.0530

1,6

LmjF27.0680

3,0 b

biopterin transporter

LinJ35_V3.5120

1,1

LmjF35.5150

2,4 b

   

LmjF36.6280,

 

glucose transporter, lmgt2

LinJ36_V3.6550

1,0

LmjF36.6290

5,6 b

pteridine transporter

LinJ06_V3.0310

1,1

LmjF06.0310

3,2 b

sugar transporter

LinJ24_V3.0690

1,0

LmjF24.0680

3,9 b

transmembrane amino acid transporter

LinJ07_V3.1340

1,1

LmjF07.1160

9,7 b

 

LinJ15_V3.1230,

   
 

LinJ15_V3.1240,

   
 

LinJ15_V3.1250,

 

LmjF15.1230,

 

nucleoside transporter 1

LinJ15_V3.1260

1,2

LmjF15.1240

4,5 b

mitochondrial ornithine transporter 1-like

LinJ16_V3.0220

1,0

LmjF16.0210

2,2 b

Cell component organization and biogenesis

dynein heavy chain

LinJ36_V3.1010

1,6

LmjF36.0950

2,6 b

kinesin

LinJ14_V3.0870

1,1

LmjF14.0810

1,8 b

kinesin

LinJ21_V3.1280

1,4

LmjF21.1040

1,9 b

   

LmjF09.0150,

 
   

LmjF09.0154,

 
   

LmjF09.0158,

 
   

LmjF09.0162,

 
   

LmjF09.0166,

 
   

LmjF09.0170,

 

microtubule associated protein

LinJ09_V3.0180

1,3

LmjF09.0174

2,5 b

 

LinJ19_V3.0820,

   

microtubule associated protein

LinJ19_V3.0850

1,1

LmjF19.0860

2,5 b

PFR

LinJ05_V3.0920

1,3

LmjF05.0920

2,3 b

PFR par4

LinJ05_V3.0040

1,3

LmjF05.0040

2,8 b

Cell communication

cAMP specific phosphodiesterase

LinJ15_V3.1550

1,5

LmjF15.1480

1,8 b

phosphodiesterase

LinJ18_V3.1100

1,4

LmjF18.1090

2,3 b

Cell motility

myosin heavy chain

LinJ32_V3.4020

1,6

LmjF32.3870

3,5 b

Unclassified

acid phophatase

LinJ36_V3.2600

1,0

LmjF36.2470

1,9 b

long chain fatty Acyl CoA synthetase

LinJ03_V3.0220

1,1

LmjF03.0230

1,9 b

 

LinJ19_V3.1350,

 

LmjF19.1340,

 

glycerol uptake protein

LinJ19_V3.1360

1,3

LmjF19.1345

1,8 b

membrane-bound acid phosphatase 2

LinJ36_V3.2720

1,1

LmjF36.2590

4,6 b

nons pecific nucleoside hydrolas e

LinJ18_V3.1570

1,1

LmjF18.1580

2,1 b

prostaglandin f2-alpha synthase

LinJ31_V3.2210

1,5

LmjF31.2150

5,1 b

 

LinJ31_V3.0950,

 

Lm jF 31.0920,

 

s odium s tibogluconate res is tance protein

LinJ31_V3.3400

1,4

LmjF31.0950

2,1 b

s urfac e antigen-lik e

LinJ04_V3.0170

1,0

Lm jF04.0180

2,0 b

s urfac e antigen-lik e

LinJ04_V3.0180

1,0

Lm jF04.0190

2,7 b

   

Lm jF 12.0850,

 
   

Lm jF 12.0860,

 
   

Lm jF 12.0870,

 

surface antigen 2

LinJ12_V3.0020

1,2

LmjF12.0890

2,1 b

ubiquitin-conjugating enzy me-like

LinJ21_V3.0500

1,6

Lm jF21.0440

2,2 b

hypothetical

LinJ03_V3.0340

1,4

Lm jF03.0360

1,9 b

   

Lm jF 04.0130,

 
   

Lm jF 04.0140,

 
   

Lm jF 04.0150,

 
   

Lm jF 04.0160,

 

hypothetical

LinJ04_V3.0160

1,1

LmjF04.0170

2,9 b

hypothetical

LinJ05_V3.1070

1,3

Lm jF05.1070

3,0 b

hypothetical

LinJ09_V3.1360

1,0

Lm jF09.1300

2,0 b

hypothetical

LinJ09_V3.1600

1,4

Lm jF09.1510

2,9 b

hypothetical

LinJ09_V3.1610

1,1

Lm jF09.1520

3,2 b

   

Lm jF 11.0670,

 
 

LinJ11_V3.0680,

 

Lm jF 11.0673,

 

hypothetical

LinJ11_V3.0690

1,0

LmjF11.0675

3,0 b

hypothetical

LinJ04_V3.1220

1,3

Lm jF04.1200

2,0 b

 

LinJ14_V3.0490,

 

Lm jF 14.0480,

 

hypothetical

LinJ14_V3.0500

1,3

LmjF14.0490

2,6 b

hypothetical

LinJ15_V3.0560

1,0

Lm jF15.0540

1,9 b

hypothetical

LinJ17_V3.0690

1,4

Lm jF17.0630

2,5 b

hypothetical

LinJ17_V3.0990

1,1

Lm jF17.0890

6,5 b

hypothetical

LinJ18_V3.1300

1,1

Lm jF18.1320

1,9 b

hypothetical

LinJ19_V3.0070

1,4

Lm jF19.0080

3,5 b

hypothetical

LinJ23_V3.0890

1,3

Lm jF23.0720

2,4 b

hypothetical

LinJ23_V3.1020

1,1

Lm jF23.0840

2,6 b

hypothetical

LinJ23_V3.1730

1,4

Lm jF23.1690

1,8 b

hypothetical

LinJ24_V3.1110

1,1

Lm jF24.1090

4,6 b

hypothetical

LinJ25_V3.2090

1,1

Lm jF25.2010

2,7 b

hypothetical

LinJ26_V3.1980

1,5

Lm jF26.1980

1,9 b

hypothetical

LinJ28_V3.0220

1,1

LmjF28.0220

1,7 b

hypothetical

LinJ28_V3.0420

1,2

LmjF28.0280

1,8 b

hypothetical

LinJ29_V3.1820

1,0

Lm jF29.1690

2,8 b

hypothetical

LinJ29_V3.2550

1,6

Lm jF29.2440

3,3 b

hypothetical

LinJ30_V3.1230

1,1

Lm jF30.1170

2,5 b

hypothetical

LinJ30_V3.2700

1,3

Lm jF30.2700

3,3 b

hypothetical

LinJ32_V3.0480

1,3

LmjF32.0470

2,0 b

hypothetical

LinJ32_V3.1760

1,4

Lm jF32.1680

3,3 b

hypothetical

LinJ32_V3.3350

1,3

Lm jF32.3150

2,3 b

hypothetical

LinJ32_V3.3650

1,3

Lm jF32.3450

1,9 b

hypothetical

LinJ33_V3.0220

1,6

Lm jF33.0210

4,0 b

hypothetical

LinJ33_V3.1040

1,0

Lm jF33.0990

3,4 b

hypothetical

LinJ33_V3.1130

1,4

LmjF33.1070

2,7 b

hypothetical

LinJ33_V3.2940

1,4

LmjF33.2800

1,7 b

hypothetical

LinJ34_V3.0210

1,1

LmjF34.0190

2,1 b

hypothetical

LinJ34_V3.0740

1,2

LmjF34.0705

1,8 b

hypothetical

LinJ34_V3.4110

1,0

LmjF34.4280

2,4 b

hypothetical

LinJ35_V3.1470

1,0

LmjF35.1460

1,7 b

hypothetical

LinJ35_V3.5400

1,2

LmjF35.5080

1,7 b

hypothetical

LinJ36_V3.0730

1,0

LmjF36.0670

2,5 b

hypothetical

LinJ36_V3.1190

1,0

LmjF36.1130

1,7 b

hypothetical

LinJ36_V3.1230

1,3

LmjF36.1170

2,1 b

hypothetical

LinJ36_V3.1520

1,1

LmjF36.1460

1,7 b

hypothetical

LinJ36_V3.4470

1,1

LmjF36.4260

2,0 b

   

Lm jF30.1410,

 
   

Lm jF30.1420,

 

ama 1

LinJ30_V3.1490

1,1

LmjF30.1430

2,1 c

   

Lm jF31.1450,

 

s urfac e membrane protein gp46-like

LinJ31_V3.1490

1,1

LmjF31.1460

2,1 c

hypothetical

LinJ06_V3.0030

1,1

LmjF06.0030

2,0 c

hypothetical

LinJ17_V3.0390

1,3

LmjF17.0340

4,0 c

hypothetical

LinJ18_V3.1110

1,1

LmjF18.1100

1,7 c

hypothetical

LinJ19_V3.1540

1,1

LmjF19.1490

1,8 c

hypothetical

LinJ20_V3.1630

1,1

LmjF20.1660

2,0 c

hypothetical

LinJ24_V3.0590

1,2

LmjF24.0580

4,8 c

hypothetical

LinJ25_V3.0230

1,3

LmjF25.0230

2,0 c

hypothetical

LinJ26_V3.1500

1,3

LmjF26.1520

3,5 c

hypothetical

LinJ28_V3.1070

1,4

LmjF28.0980

2,6 c

hypothetical

LinJ28_V3.2860

1,2

LmjF28.2660

2,0 c

hypothetical

LinJ31_V3.2910

1,4

LmjF31.2810

2,1 c

hypothetical

LinJ32_V3.2620

1,3

LmjF32.2480

1,8 c

hypothetical

LinJ35_V3.4870

1,3

LmjF35.4810

1,8 c

hypothetical

LinJ36_V3.2960

1,1

LmjF36.2820

1,9 c

hypothetical

LinJ36_V3.3480

1,3

LmjF36.3320

1,7 c

hypothetical

LinJ36_V3.4870

1,0

LmjF36.4640

2,0 c

  1. a Only non-modulated genes are listed in this column.
  2. b Genes differentially expressed in promastigotes.
  3. c Genes differentially expressed in amastigotes.