Figure 4

Alignment of the amino acid sequence of LLAE0040C, from L. laeta venom glands, with known 5'-nucleotidases. Residues are numbered according to the aligned 5'-nucleotidase sequences and dots represent gaps introduced to improve alignment. The underlined amino acid sequence indicates the putative signal peptide. The conserved cystein residues are indicated by asterisks. Black and gray indicate amino acids that are identical or conserved, respectively. The 5'-nucleotidases active site regions are indicate by crosses. The abbreviation and GenBank accession number for the 5'-nucleotidases sequences aligned are: 5'nuct1, Glossina morsitans morsitans 5'-nucleotidase (ABN80093); 5'nuct2, Aedes aegypti 5'-nucleotidase (ABF18486) and 5'nuct3, Anopheles gambiae 5'-nucleotidase (CAB40347).