Figure 8
Phylogenetic relationship of Jmjd6 to other JmjC domain containing proteins. Detailed section of the phylogenetic tree of 313 JmjC proteins that is presented [in additional file 6]. Shown are 12 out of 25 identified DSBH fold containing protein subgroups as indicated with protein family names on the right side. Scale bar represents the relative phylogenetic distance as determined with PHYLIP. Bootstrap values are shown for values <1000. The first column of the table shows the residues potentially involved in iron binding. The second, third and fourth columns show potentially important residues within the -3, +6–8 and +13–15 regions in respect to the Hx(D/E/H) motif, respectively. Residues discussed in the text are highlighted in red, orange, blue, green and yellow. The fifth column shows the predicted ability to build an extended major sheet with three antiparallel β-strands as determined by Jpred. A "+" indicates the presence of three beta strands, a "?" two beta-strands and a "-" no predicted beta-strands within a 50 aa window starting 80 aa before the first β-strand from the JmjC jelly-roll. H.s. = Homo sapiens, M.m. = Mus musculus, D.r. = Danio rerio, T.n. = Tetraodon nigroviridis, T.r. = Takifugu rubripes, D.m. = Drosophila melanogaster, C.e. = Caenorhabditis elegans, S.c. = Saccharomyces cerevisiae, S.p. = Schizosaccharomyces pombe.