Immunity related genes in dipterans share common enrichment of AT-rich motifs in their 5' regulatory regions that are potentially involved in nucleosome formation

Table 8 Motif overrepresentation in 5' upstream sequences (2,500 bp) of immunity-induced genes.

Organism	Motif length (bp)	Motif	sig_occ
*Anopheles gambiae*	2	AA	20.99
		TA	14.39
		AT	13.25
	3	AAA	6.11
		TCA	2.84
		AAC	2.17
	4	ATAA	11.26
		AATA	8.82
		TTAA	4.62
	5	AATAA	9.37
		ATAAA	5.1
		AATAC	3.7
	6	CAATAC	2.53
		AATAAT	2.19
		ATAATG	1.5
	7	AAAATAA	1.3
		ATTATTA	0.41
		AAATAAA	0.33
*Drosophila melanogaster*	2	AA	37.43
		TA	15.64
		AT	14.8
	3	AAA	22.3
		GAA	1.45
		AAG	0.95
	4	AAAA	16.61
		ATAA	14.21
		TAAA	9.59
	5	TAAAA	10.75
		AAAAT	8.29
		ATAAA	7.49
	6	TGATAA	5.97
		TAAAAA	5.64
		ATAAAA	5.36
	7	GAAAAAC	2.73
		TTAAAAA	2.39
		CTTATCA	2.03

First three motifs statistically overrepresented found with Oligo-Analysis for each motif length, in A. gambiae and D. melanogaster upregulated immunity genes. In bold are indicated motifs with high sig_occ conserved in both insects.

ISSN: 1471-2164