From: Effects of increased milking frequency on gene expression in the bovine mammary gland
 |  | Number of tags |  |  |  | |
---|---|---|---|---|---|---|
Tag | Gene symbol | Control | IMF4 | P-value | UniGene annotation | Putative function |
Genes up regulated in IMF4 | ||||||
GCTCCAGGAC | GCHFR | 0 | 9 | 0.0034 | GTP cyclohydrolase I feedback regulator | regulation of NO synthesis |
GACGACACGA | RPS28 | 0 | 6 | 0.0214 | ribosomal protein S28 | protein biosynthesis |
CAGCAAGGTG | STK19 | 0 | 5 | 0.0385 | serine/threonine kinase 19 | transcriptional regulation |
TCTCCCCTGT | GAK | 0 | 5 | 0.0385 | cyclin G associated kinase | membrane trafficking, putative tumor suppressor |
AGGAGTTGGG | Â | 1 | 14 | 0.001 | major histocompatibility complex, class I, A | immune response |
GGCCTGATCG | LTF | 2 | 17 | 0.0009 | lactotransferrin | defense against bacterial infection |
GAAATCATTG | UGP2 | 2 | 10 | 0.0304 | UDP-glucose pyrophosphorylase 2 | lactose synthesis |
CCGGTATAAA | Â | 4 | 15 | 0.0214 | unique2 | Â |
CCGGTCGCCC | RPS9 | 8 | 23 | 0.0124 | ribosomal protein S9 | protein biosynthesis |
GCAGTGGTAG | Â | 8 | 23 | 0.0124 | unknown3 | Â |
GCGGCCAGCG | LGB | 12 | 32 | 0.0064 | β-lactoglobulin | component of whey protein |
CAGATATAGG | Â | 15 | 31 | 0.0351 | unknown | Â |
GCCGGCCCGG | RPS15 | 23 | 44 | 0.0253 | ribosomal protein S15 | protein biosynthesis |
GGCAGGGCCT | H2AFY2 | 48 | 87 | 0.0045 | H2A histone family, member Y2 | transcriptional regulation |
CAGAAGAGCA | Â | 24 | 42 | 0.0481 | unique | Â |
ATACTACTGG | Â | 70 | 120 | 0.0033 | unique | Â |
Genes down regulated in IMF4 | ||||||
CCTTTGAAGT | GLYCAM1 | 117 | 92 | 0.0055 | glycosylation dependent cell adhesion molecule 1 | cell adhesion molecule |
TCCATTGTCA | Â | 67 | 51 | 0.0185 | unknown | Â |
GTAGTTGGCT | Â | 106 | 80 | 0.0037 | unique | Â |
AACATATCAA | CSN2 | 894 | 574 | 0 | β-casein | defense against infection |
GGAAAGGCGG | MFGE8 | 29 | 18 | 0.0303 | milk fat globule-EGF factor 8 protein (lactadherin) | remodeling during mammary involution, neovascularization |
AATGGCGCTC | LALBA | 195 | 120 | 0 | α-lactalbumin | lactose synthesis, antimicrobial and anti-tumor function in neonate |
GGTTCAAAAC | Â | 20 | 10 | 0.0235 | unknown | Â |
GCTGAATAAA | MUC1 | 13 | 6 | 0.0486 | mucin 1, transmembrane | defense against microbial infection, cell signaling |
GAATAGGATG | Â | 21 | 8 | 0.0045 | unknown | Â |
CACCCCTGGA | Â | 11 | 4 | 0.0379 | unknown | Â |
CAAACTCTTG | ATOX1 | 11 | 3 | 0.0163 | antioxidant protein 1 | ion transport, protective role in oxidative stress |
AAAATAAAAG | CXCL3 | 8 | 2 | 0.0405 | chemokine (C-X-C motif) ligand 3 | immune response |
ACCCTGTGCC | Â | 9 | 2 | 0.0216 | LOC506990 | Â |
ACCAAAAACC | COL1A1 | 27 | 5 | 0 | type I collagen, α-1 | component of extracellular matrix |
ACCCGGCTGA | Â | 6 | 1 | 0.0406 | MGC127561 | Â |
ATCAATAAAG | CAPG | 7 | 1 | 0.0229 | capping protein (actin filament), gelsolin-like | tumor suppressor, control of cellular motility |
CTCGATGAAA | XBP1 | 8 | 1 | 0.0135 | X-box binding protein 1 | immune response |
GCCCACAAAG | FGFBP1 | 9 | 1 | 0.0065 | fibroblast growth factor binding protein 1 | epithelial cell repair after injury, angiogenesis |
GCGCCCCTGC | Â | 10 | 0 | 0.0006 | major histocompatibility complex, class I, A | immune response |
CACACCCGGC | MRPL45 | 8 | 0 | 0.0024 | mitochondrial ribosomal protein L45 | protein biosynthesis |
GTCTTTAATT | Â | 8 | 0 | 0.0024 | unknown | Â |
CTTTGTGTGC | ALDOC | 5 | 0 | 0.0225 | aldolase C, fructose-bisphosphate | cellular metabolism |
GGCCCAGTTT | PPIB | 5 | 0 | 0.0225 | cyclophilin B | chaperone facilitating action of lactogenic hormones, inflammatory response |
CAGATTTGTG | DDX24 | 4 | 0 | 0.0467 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 24 | RNA helicase |
CCCGCGGAAA | SAA3P | 4 | 0 | 0.0467 | serum amyloid A3 | defense against bacterial infection, remodeling of mammary gland |
GCCGAAGCTA | TSC2 | 4 | 0 | 0.0467 | tuberous sclerosis 2 | inhibitor of cell growth and proliferation |
TGAGGCTCAC | QDPR | 4 | 0 | 0.0467 | quinoid dihydropteridine reductase | L-phenylalanine catabolism |
TTTGGTTTTC | COL1A2 | 4 | 0 | 0.0467 | type I collagen,α-2 | component of extracellular matrix |
GCTCCAGGAC | GCHFR | 0 | 9 | 0.0034 | GTP cyclohydrolase I feedback regulator | regulation of NO synthesis |
GACGACACGA | RPS28 | 0 | 6 | 0.0214 | ribosomal protein S28 | protein biosynthesis |
CAGCAAGGTG | STK19 | 0 | 5 | 0.0385 | serine/threonine kinase 19 | transcriptional regulation |
TCTCCCCTGT | GAK | 0 | 5 | 0.0385 | cyclin G associated kinase | membrane trafficking, putative tumor suppressor |
AGGAGTTGGG | Â | 1 | 14 | 0.001 | major histocompatibility complex, class I, A | immune response |
GGCCTGATCG | LTF | 2 | 17 | 0.0009 | lactotransferrin | defense against bacterial infection |
GAAATCATTG | UGP2 | 2 | 10 | 0.0304 | UDP-glucose pyrophosphorylase 2 | lactose synthesis |
CCGGTATAAA | Â | 4 | 15 | 0.0214 | unique2 | Â |