Table 1 Gene symbol, description, and overall % mRNA abundance among genes investigated
From: Gene networks driving bovine milk fat synthesis during the lactation cycle
FA import into cells | % RNA1 | Triacylglycerol synthesis | % RNA | ||
|---|---|---|---|---|---|
LPL | Lipoprotein lipase | 9.56 | GPAM | Glycerol-3-phosphate acyltransferase, mitochondrial | 2.31 |
CD36 | CD36 molecule (thrombospondin receptor) | 4.66 | AGPAT6 | 1-acylglycerol-3-phosphate O-acyltransferase 6 | 1.28 |
VLDLR | Very-Low Density Lipoprotein Receptor | 0.09 | DGAT1 | Diacylglycerol acyltransferase 1 | 0.14 |
Xenobiotic and Cholesterol transport | Â | DGAT2 | Diacylglycerol acyltransferase 2 | <0.01 | |
ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.07 | LPIN1 | Lipin 1 | 0.13 |
ABCG2 | ATP-binding cassette, sub-family G (WHITE), member 2 | 8.54 | Regulation of transcription | Â | |
Acetate and FA activation and intra-cellular transport | Â | INSIG1 | Insulin induced gene 1 | 0.35 | |
ACSS1 | acyl-CoA synthetase short-chain family member 1 | 0.33 | INSIG2 | Insulin induced gene 2 | 0.09 |
ACSS2 | acyl-CoA synthetase short-chain family member 2 | 0.59 | SCAP | SREBP cleavage activating protein | 0.13 |
ACSL1 | Acyl-CoA synthetase long-chain family member 1 | 0.89 | SREBF1 | Sterol regulatory element-binding transcription factor 1 | 0.15 |
ACBP | Acyl-CoA binding protein (diazepam binding inhibitor) | 0.17 | SREBF2 | Sterol regulatory element-binding transcription factor 2 | 0.10 |
FABP3 | Fatty acid-binding protein, heart | 15.49 | THRSP | Thyroid hormone responsive SPOT14 | 0.01 |
Fatty acid synthesis and desaturation | Â | PPARG | Peroxisome proliferator-activated receptor gamma | 0.01 | |
ACACA | Acetyl-coenzyme A carboxylase alpha | 0.91 | PPARGC1A | PPAR gamma, coactivator 1 alpha | 0.04 |
FADS1 | Fatty acid desaturase 1 (delta-5 desaturase) | 0.20 | PPARGC1B | PPAR gamma, coactivator 1 beta | 0.01 |
FADS2 | Fatty acid desaturase 2 (delta-6 desaturase) | <0.01 | Sphingolipid synthesis | Â | |
FASN | Fatty acid synthase | 7.05 | SPTLC1 | Serine palmitoyltransferase, long chain base subunit 1 | 0.15 |
SCD | Stearoyl-CoA desaturase (delta-9-desaturase) | 23.14 | SPTLC2 | Serine palmitoyltransferase, long chain base subunit 2 | 0.15 |
Lipid droplet formation | Â | LASS2 | LAG1 homolog, ceramide synthase 2 | 0.61 | |
ADFP | Adipose differentiation related protein (adipophilin) | 9.56 | SPHK2 | Sphingosine kinase 2 | 0.09 |
BTN1A1 | Butyrophilin, subfamily 1, member A1 | 4.78 | ASAHL | N-acylsphingosine amidohydrolase-like | 0.05 |
XDH | Xanthine dehydrogenase | 7.39 | SGPL1 | Sphingosine-1-phosphate lyase | 0.06 |
PLIN | Perilipin | 0.01 | UGCG | Ceramide glucosyltransferase | 0.18 |
Ketone body utilization | Â | OSBP | Oxysterol-binding protein 1 | 0.12 | |
BDH1 | 3-hydroxybutyrate dehydrogenase, type 1 | 0.02 | OSBPL2 | Oxysterol binding protein-like 2 | 0.17 |
OXCT1 | 3-oxoacid CoA transferase 1 | 0.07 | OSBPL10 | Oxysterol binding protein-like 10 | 0.06 |