Asbestos induces a p53-mediated response in A549 lung cells. Experimental data is indicated by the thick blue edges and is discussed in more detail in the text. Known p53 targets which may have a role in the asbestos response and their biological effects are shown using thin gray lines. Nodes are color coded shades of red when expression levels increased and shades of blue when expression levels decreased. Nodes surrounded by dashed lines represent genes/gene products which were not represented on the gene chip but which displayed a functional relationship to queried nodes.