From: Altered gene expression in highly purified enterocytes from patients with active coeliac disease
Functional Category | Gene Name | GenBank Accession Number | Chromosome Location | Fold-change | p-value |
---|---|---|---|---|---|
Protein Transport | peroxisome biogenesis factor 13 | NM_002618 | 2p14-p16 | 2.276 | 0.00331 |
 | gap junction protein, alpha 4, 37 kDa (connexin 37) | NM_002060 | 1p35.1 | 1.952 | 0.00575 |
 | syntaxin 3A | NM_004177 | 11q12.1 | 1.81 | 0.00578 |
 | CD3G antigen, gamma polypeptide (TiT3 complex) | NM_000073 | 11q23 | 1.547 | 0.00676 |
 | retinol dehydrogenase 5 (11-cis and 9-cis) | NM_002905 | 12q13-q14 | 1.446 | 0.0158 |
 | exportin 1 (CRM1 homolog, yeast) | NM_003400 | 2p15 | 1.847 | 0.0225 |
 | A kinase (PRKA) anchor protein 1 | NM_005751 | 7q21-q22 | 0.748 | 0.0248 |
 | retinol binding protein 1, cellular | NM_002899 | 3q21-q23 | 0.692 | 0.0305 |
Ion Transport | gamma-aminobutyric acid (GABA) A receptor, beta 3 | NM_000814 | 15q11.2-q12 | 1.74 | 0.00286 |
 | cholinergic receptor, nicotinic, alpha polypeptide 5 | NM_000745 | 15q24 | 0.557 | 0.00605 |
 | hemochromatosis | NM_000410 | 6p21.3 | 1.319 | 0.00924 |
 | potassium voltage-gated channel, Isk-related family, member 1 | NM_000219 | 21q22.12 | 1.369 | 0.00959 |
 | calcium channel, voltage-dependent, L type, alpha 1C subunit | NM_000719 | 12p13.3 | 1.351 | 0.0112 |
 | sorcin | NM_003130 | 7q21.1 | 1.316 | 0.0248 |
 | ATPase, H+ transporting, lysosomal 70 kDa, V1 subunit A | NM_001691 | 3q13.2-q13.31 | 1.47 | 0.0364 |
 | glutamate receptor, ionotropic, N-methyl D-aspartate 1 | NM_000832 | 9q34.3 | 0.706 | 0.0368 |
 | adenosine kinase | NM_001123 | 10q22.2 | 0.749 | 0.0406 |
Proliferation | bone marrow stromal cell antigen 2 | NM_004335 | 19p13.2 | 1.29 | 0.00975 |
 | PRKC, apoptosis, WT1, regulator | NM_002583 | 12q21 | 0.73 | 0.0251 |
 | v-Ha-ras Harvey rat sarcoma viral oncogene homolog | NM_005343 | 11p15.5 | 0.631 | 0.0282 |
 | growth arrest-specific 6 | NM_000820 | 13q34 | 1.576 | 0.0443 |
Differentiation | nuclear transcription factor Y, alpha | NM_002505 | 6p21.3 | 0.714 | 0.0196 |
 | homeo box A7 | NM_006896 | 7p15-p14 | 1.701 | 0.0297 |
 | ash2 (absent, small, or homeotic)-like (Drosophila) | NM_004674 | 8p11.2 | 0.749 | 0.0368 |
 | wingless-type MMTV integration site family, member 7A | NM_004625 | 3p25 | 1.33 | 0.044 |
Anti-apoptosis/Survival | PTK2B protein tyrosine kinase 2 beta | NM_004103 | 8p21.1 | 0.719 | 0.00362 |
 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 | NM_001396 | 21q22.13 | 2.627 | 0.0304 |
 | tumor necrosis factor receptor superfamily, member 18 | NM_004195 | 1p36.3 | 1.941 | 0.0334 |
 | Erythropoietin | NM_000799 | 7q22 | 2.738 | 0.0492 |
Transcription | SRY (sex determining region Y)-box 14 | NM_006942 | 17p13 | 0.732 | 0.0142 |
 | hematopoietic cell-specific Lyn substrate 1 | NM_005335 | 3q13 | 1.585 | 0.0164 |
 | histone deacetylase 2 | NM_001527 | 6q21 | 1.574 | 0.0178 |
 | high-mobility group box 3 | NM_002128 | 13q12 | 1.775 | 0.02 |
 | ELK4, ETS-domain protein (SRF accessory protein 1) | NM_001973 | 1q32 | 1.446 | 0.0216 |
 | homeo box A11 | NM_005523 | 7p15-p14 | 1.325 | 0.0246 |
 | forkhead box G1B | NM_005249 | 14q13 | 1.558 | 0.0248 |
 | notch homolog 3 (Drosophila) | NM_000435 | 19p13.2-p13.1 | 1.271 | 0.0285 |
 | paired box gene 8 | NM_003466 | 2q12-q14 | 1.419 | 0.0289 |
 | human T-cell leukemia virus enhancer factor | NM_002158 | 2p22-p16 | 1.267 | 0.0311 |
 | methyl CpG binding protein 2 (Rett syndrome) | NM_004992 | Xq28 | 0.532 | 0.0326 |
 | T-box 6 | NM_004608 | 16p11.2 | 0.73 | 0.037 |
 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68 kDa | NM_003487 | 17q11.1-q11.2 | 0.656 | 0.0432 |
 | neuronal PAS domain protein 2 | NM_002518 | 2q11.2 | 1.288 | 0.0497 |
Metabolism | fructose-1,6-bisphosphatase 1 | NM_000507 | 9q22.3 | 1.535 | 0.000296 |
 | glucosidase, beta; acid (includes glucosylceramidase) | NM_000157 | 1q21 | 1.258 | 0.000369 |
 | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) | NM_002130 | 5p14-p13 | 0.535 | 0.00679 |
 | lipoprotein, Lp(a) | NM_005577 | 6q26 | 1.653 | 0.0174 |
 | dihydropyrimidinase | NM_001385 | 8q22 | 0.638 | 0.0205 |
 | NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23 kDa (NADH-coenzyme Q reductase) | NM_002496 | 11q13 | 0.78 | 0.0242 |
 | histatin 1 | NM_002159 | 4q13 | 0.75 | 0.0256 |
 | N-acetylgalactosaminidase, alpha- | NM_000262 | 22q13-qter; 22q11 | 0.783 | 0.0278 |
 | choline kinase | NM_001277 | 11q13.2 | 1.507 | 0.0303 |
 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | NM_004567 | 3p22-p21 | 0.648 | 0.032 |
 | sterol regulatory element binding transcription factor 1 | NM_004176 | 17p11.2 | 4.529 | 0.0354 |
Structural | cytoplasmic linker 2 | NM_003388 | 7q11.23 | 1.309 | 0.00603 |
 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase (lysine hydroxylase) 2 | NM_000935 | 3q23-q24 | 1.563 | 0.00657 |
 | spectrin, alpha, erythrocytic 1 (elliptocytosis 2) | NM_003126 | 1q21 | 1.29 | 0.0108 |
 | cystatin A (stefin A) | NM_005213 | 3q21 | 1.48 | 0.0114 |
 | integrin beta 4 binding protein | NM_002212 | 20q12 | 2.356 | 0.0167 |
 | envoplakin | NM_001988 | 17q25 | 0.69 | 0.0201 |
 | tubulin-specific chaperone a | NM_004607 | 5q14.1 | 0.725 | 0.0239 |
 | microtubule-associated protein 1A | NM_002373 | 15q13-qter | 0.652 | 0.0395 |
 | small proline-rich protein 3 | NM_005416 | 1q21-q22 | 2.095 | 0.0398 |
Adhesion | vinculin | NM_003373 | 10q22.2 | 1.752 | 0.00217 |
 | matrix Gla protein | NM_000900 | 12p13.1-p12.3 | 0.659 | 0.00909 |
 | EGF-containing fibulin-like extracellular matrix protein 1 | NM_004105 | 2p16 | 1.276 | 0.0273 |
 | oligodendrocyte myelin glycoprotein | NM_002544 | 17q11.2 | 2.008 | 0.0386 |
 | growth factor receptor-bound protein 7matrix Gla protein | NM_005310 | 17q12 | 1.564 | 0.0479 |
Protein Synthesis | ribosomal protein L19 | NM_000981 | 17q11.2-q12 | 1.744 | 0.00118 |
 | eukaryotic translation elongation factor 1 beta 2 | NM_001959 | 2q33-q34 | 1.413 | 0.0051 |
 | ribosomal protein S29 | NM_001032 | 14q | 1.311 | 0.00579 |
 | pyrroline-5-carboxylate reductase 1 | NM_006907 | 17q25.3 | 1.31 | 0.0059 |
 | aminolevulinate, delta-, synthase 1 | NM_000688 | 3p21.1 | 1.453 | 0.0105 |
 | eukaryotic translation initiation factor 4E binding protein 3 | NM_003732 | 5q31.3 | 1.466 | 0.0143 |
 | tyrosinase (oculocutaneous albinism IA) | NM_000372 | 11q14-q21 | 1.272 | 0.0387 |
Immune Response & Inflammation | MAP/microtubule affinity-regulating kinase 2 | NM_004954 | 11q12-q13 | 0.717 | 0.00307 |
 | microseminoprotein, beta- | NM_002443 | 10q11.2 | 1.592 | 0.0113 |
 | sialyltransferase 1 (beta-galactoside alpha-2,6-sialyltransferase) | NM_003032 | 3q27-q28 | 1.547 | 0.0207 |
 | pyruvate kinase, muscle | NM_002654 | 15q22 | 1.438 | 0.031 |
 | superkiller viralicidic activity 2-like (S. cerevisiae) | NM_006929 | 6p21 | 1.639 | 0.0401 |
Signal Transduction | natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A) | NM_000906 | 1q21-q22 | 0.693 | 0.00936 |
 | membrane protein, palmitoylated 3 (MAGUK p55 subfamily) member 3) | NM_001932 | 17q21.31 | 1.259 | 0.0109 |
 | GPI anchored molecule like protein | NM_007264 | 12q13.3 | 1.791 | 0.0116 |
 | glutamate receptor, metabotropic 7 | NM_000844 | 3p26.1-p25.1 | 0.768 | 0.026 |
 | G protein-coupled receptor 7 | NM_005285 | 8p22-q21.13 | 2.293 | 0.0265 |
 | Ras-like without CAAX 1 | NM_006912 | 1q22 | 1.306 | 0.0356 |
 | retinal G protein coupled receptor | NM_002921 | 10q23 | 0.744 | 0.0458 |
 | AND-1 protein | NM_007086 | 14q22.3 | 1.659 | 0.0465 |
Cell cycle & DNA repair | developmentally regulated GTP binding protein 1 | NM_004147 | 22q12.2 | 1.56 | 0.00551 |
 | protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) | NM_006223 | Xq13 | 0.628 | 0.0086 |
 | flap structure-specific endonuclease 1 | NM_004111 | 11q12 | 1.288 | 0.0167 |
 | BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) | NM_004656 | 3p21.31-p21.2 | 1.316 | 0.0185 |
 | amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) | NM_001164 | 11p15 | 2.218 | 0.0234 |
 | ubiquitin protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome) | NM_000462 | 15q11-q13 | 0.771 | 0.0286 |
 | nudix (nucleoside diphosphate linked moiety X)-type motif 2 | NM_001161 | 9p13 | 2.209 | 0.037 |
Miscellaneous | chromosome 18 open reading frame 1 | NM_004338 | 18p11.2 | 1.743 | 0.0298 |
 | prion protein (p27-30) (Creutzfeld-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia) | NM_000311 | 20p13 | 0.539 | 0.00875 |
 | oxidase (cytochrome c) assembly 1-like | NM_005015 | 14q11.2 | 0.625 | 0.0241 |
 | D-amino-acid oxidase | NM_001917 | 12q24 | 1.75 | 0.03 |
 | chromosome X open reading frame 2 | NM_001586 | Xq28 | 0.762 | 0.0308 |
 | transmembrane 7 superfamily member 1 (upregulated in kidney) | NM_003272 | 1q42-q43 | 0.761 | 0.0371 |
 | ribonuclease, RNase A family, 4 | NM_002937 | 14q11.1 | 1.279 | 0.0467 |