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Table 1 Differentially expressed genes.

From: Altered gene expression in highly purified enterocytes from patients with active coeliac disease

Functional Category Gene Name GenBank Accession Number Chromosome Location Fold-change p-value
Protein Transport peroxisome biogenesis factor 13 NM_002618 2p14-p16 2.276 0.00331
  gap junction protein, alpha 4, 37 kDa (connexin 37) NM_002060 1p35.1 1.952 0.00575
  syntaxin 3A NM_004177 11q12.1 1.81 0.00578
  CD3G antigen, gamma polypeptide (TiT3 complex) NM_000073 11q23 1.547 0.00676
  retinol dehydrogenase 5 (11-cis and 9-cis) NM_002905 12q13-q14 1.446 0.0158
  exportin 1 (CRM1 homolog, yeast) NM_003400 2p15 1.847 0.0225
  A kinase (PRKA) anchor protein 1 NM_005751 7q21-q22 0.748 0.0248
  retinol binding protein 1, cellular NM_002899 3q21-q23 0.692 0.0305
Ion Transport gamma-aminobutyric acid (GABA) A receptor, beta 3 NM_000814 15q11.2-q12 1.74 0.00286
  cholinergic receptor, nicotinic, alpha polypeptide 5 NM_000745 15q24 0.557 0.00605
  hemochromatosis NM_000410 6p21.3 1.319 0.00924
  potassium voltage-gated channel, Isk-related family, member 1 NM_000219 21q22.12 1.369 0.00959
  calcium channel, voltage-dependent, L type, alpha 1C subunit NM_000719 12p13.3 1.351 0.0112
  sorcin NM_003130 7q21.1 1.316 0.0248
  ATPase, H+ transporting, lysosomal 70 kDa, V1 subunit A NM_001691 3q13.2-q13.31 1.47 0.0364
  glutamate receptor, ionotropic, N-methyl D-aspartate 1 NM_000832 9q34.3 0.706 0.0368
  adenosine kinase NM_001123 10q22.2 0.749 0.0406
Proliferation bone marrow stromal cell antigen 2 NM_004335 19p13.2 1.29 0.00975
  PRKC, apoptosis, WT1, regulator NM_002583 12q21 0.73 0.0251
  v-Ha-ras Harvey rat sarcoma viral oncogene homolog NM_005343 11p15.5 0.631 0.0282
  growth arrest-specific 6 NM_000820 13q34 1.576 0.0443
Differentiation nuclear transcription factor Y, alpha NM_002505 6p21.3 0.714 0.0196
  homeo box A7 NM_006896 7p15-p14 1.701 0.0297
  ash2 (absent, small, or homeotic)-like (Drosophila) NM_004674 8p11.2 0.749 0.0368
  wingless-type MMTV integration site family, member 7A NM_004625 3p25 1.33 0.044
Anti-apoptosis/Survival PTK2B protein tyrosine kinase 2 beta NM_004103 8p21.1 0.719 0.00362
  dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 NM_001396 21q22.13 2.627 0.0304
  tumor necrosis factor receptor superfamily, member 18 NM_004195 1p36.3 1.941 0.0334
  Erythropoietin NM_000799 7q22 2.738 0.0492
Transcription SRY (sex determining region Y)-box 14 NM_006942 17p13 0.732 0.0142
  hematopoietic cell-specific Lyn substrate 1 NM_005335 3q13 1.585 0.0164
  histone deacetylase 2 NM_001527 6q21 1.574 0.0178
  high-mobility group box 3 NM_002128 13q12 1.775 0.02
  ELK4, ETS-domain protein (SRF accessory protein 1) NM_001973 1q32 1.446 0.0216
  homeo box A11 NM_005523 7p15-p14 1.325 0.0246
  forkhead box G1B NM_005249 14q13 1.558 0.0248
  notch homolog 3 (Drosophila) NM_000435 19p13.2-p13.1 1.271 0.0285
  paired box gene 8 NM_003466 2q12-q14 1.419 0.0289
  human T-cell leukemia virus enhancer factor NM_002158 2p22-p16 1.267 0.0311
  methyl CpG binding protein 2 (Rett syndrome) NM_004992 Xq28 0.532 0.0326
  T-box 6 NM_004608 16p11.2 0.73 0.037
  TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68 kDa NM_003487 17q11.1-q11.2 0.656 0.0432
  neuronal PAS domain protein 2 NM_002518 2q11.2 1.288 0.0497
Metabolism fructose-1,6-bisphosphatase 1 NM_000507 9q22.3 1.535 0.000296
  glucosidase, beta; acid (includes glucosylceramidase) NM_000157 1q21 1.258 0.000369
  3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) NM_002130 5p14-p13 0.535 0.00679
  lipoprotein, Lp(a) NM_005577 6q26 1.653 0.0174
  dihydropyrimidinase NM_001385 8q22 0.638 0.0205
  NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23 kDa (NADH-coenzyme Q reductase) NM_002496 11q13 0.78 0.0242
  histatin 1 NM_002159 4q13 0.75 0.0256
  N-acetylgalactosaminidase, alpha- NM_000262 22q13-qter; 22q11 0.783 0.0278
  choline kinase NM_001277 11q13.2 1.507 0.0303
  6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 NM_004567 3p22-p21 0.648 0.032
  sterol regulatory element binding transcription factor 1 NM_004176 17p11.2 4.529 0.0354
Structural cytoplasmic linker 2 NM_003388 7q11.23 1.309 0.00603
  procollagen-lysine, 2-oxoglutarate 5-dioxygenase (lysine hydroxylase) 2 NM_000935 3q23-q24 1.563 0.00657
  spectrin, alpha, erythrocytic 1 (elliptocytosis 2) NM_003126 1q21 1.29 0.0108
  cystatin A (stefin A) NM_005213 3q21 1.48 0.0114
  integrin beta 4 binding protein NM_002212 20q12 2.356 0.0167
  envoplakin NM_001988 17q25 0.69 0.0201
  tubulin-specific chaperone a NM_004607 5q14.1 0.725 0.0239
  microtubule-associated protein 1A NM_002373 15q13-qter 0.652 0.0395
  small proline-rich protein 3 NM_005416 1q21-q22 2.095 0.0398
Adhesion vinculin NM_003373 10q22.2 1.752 0.00217
  matrix Gla protein NM_000900 12p13.1-p12.3 0.659 0.00909
  EGF-containing fibulin-like extracellular matrix protein 1 NM_004105 2p16 1.276 0.0273
  oligodendrocyte myelin glycoprotein NM_002544 17q11.2 2.008 0.0386
  growth factor receptor-bound protein 7matrix Gla protein NM_005310 17q12 1.564 0.0479
Protein Synthesis ribosomal protein L19 NM_000981 17q11.2-q12 1.744 0.00118
  eukaryotic translation elongation factor 1 beta 2 NM_001959 2q33-q34 1.413 0.0051
  ribosomal protein S29 NM_001032 14q 1.311 0.00579
  pyrroline-5-carboxylate reductase 1 NM_006907 17q25.3 1.31 0.0059
  aminolevulinate, delta-, synthase 1 NM_000688 3p21.1 1.453 0.0105
  eukaryotic translation initiation factor 4E binding protein 3 NM_003732 5q31.3 1.466 0.0143
  tyrosinase (oculocutaneous albinism IA) NM_000372 11q14-q21 1.272 0.0387
Immune Response & Inflammation MAP/microtubule affinity-regulating kinase 2 NM_004954 11q12-q13 0.717 0.00307
  microseminoprotein, beta- NM_002443 10q11.2 1.592 0.0113
  sialyltransferase 1 (beta-galactoside alpha-2,6-sialyltransferase) NM_003032 3q27-q28 1.547 0.0207
  pyruvate kinase, muscle NM_002654 15q22 1.438 0.031
  superkiller viralicidic activity 2-like (S. cerevisiae) NM_006929 6p21 1.639 0.0401
Signal Transduction natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A) NM_000906 1q21-q22 0.693 0.00936
  membrane protein, palmitoylated 3 (MAGUK p55 subfamily) member 3) NM_001932 17q21.31 1.259 0.0109
  GPI anchored molecule like protein NM_007264 12q13.3 1.791 0.0116
  glutamate receptor, metabotropic 7 NM_000844 3p26.1-p25.1 0.768 0.026
  G protein-coupled receptor 7 NM_005285 8p22-q21.13 2.293 0.0265
  Ras-like without CAAX 1 NM_006912 1q22 1.306 0.0356
  retinal G protein coupled receptor NM_002921 10q23 0.744 0.0458
  AND-1 protein NM_007086 14q22.3 1.659 0.0465
Cell cycle & DNA repair developmentally regulated GTP binding protein 1 NM_004147 22q12.2 1.56 0.00551
  protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) NM_006223 Xq13 0.628 0.0086
  flap structure-specific endonuclease 1 NM_004111 11q12 1.288 0.0167
  BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) NM_004656 3p21.31-p21.2 1.316 0.0185
  amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) NM_001164 11p15 2.218 0.0234
  ubiquitin protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome) NM_000462 15q11-q13 0.771 0.0286
  nudix (nucleoside diphosphate linked moiety X)-type motif 2 NM_001161 9p13 2.209 0.037
Miscellaneous chromosome 18 open reading frame 1 NM_004338 18p11.2 1.743 0.0298
  prion protein (p27-30) (Creutzfeld-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia) NM_000311 20p13 0.539 0.00875
  oxidase (cytochrome c) assembly 1-like NM_005015 14q11.2 0.625 0.0241
  D-amino-acid oxidase NM_001917 12q24 1.75 0.03
  chromosome X open reading frame 2 NM_001586 Xq28 0.762 0.0308
  transmembrane 7 superfamily member 1 (upregulated in kidney) NM_003272 1q42-q43 0.761 0.0371
  ribonuclease, RNase A family, 4 NM_002937 14q11.1 1.279 0.0467
  1. Genes are ranked within each category according to their significance.