Dynamic RNA profiling in Plasmodium falciparum synchronized blood stages exposed to lethal doses of artesunate

BMC Genomics

Table 3 Differentially expressed transport associated genes in artesunate-treated cells

Gene ID	Description	ART 90 min	ART 3 h	HS	CQ
PF07_0121	NMD3 protein, putative		0,85
PFB0435c	amino acid transporter, putative		0,89
PFE1455w	sugar transporter, putative		0,92		+
PFE1150w	multidrug resistance protein, Pfmdr1		1,10
PF11_0141	UDP-galactose transporter, putative	-0,86	-0,82	-
PFC0725c	formate-nitrate transporter, putative		-1,16	-
MAL8P1.13	integral membrane protein, conserved/folate-Biopterin transporter		-1,13
MAL13P1.206	Na+ -dependent Pi transporter, sodium-dependent phosphate transporter PfPiT		-0,90
PF13_0252	nucleoside transporter 1 PfNT1/PfENT1		-1,32
PFL0170w	Transporter, major facilitator superfamily		-0,86	-
PFE0410w	triose or hexose phosphate/phosphate translocator, putative		-0,88	-
PF13_0227	vacuolar ATP synthase subunit D, putative		-0,92
PF11_0412	Vacuolar ATP synthase subunit F, putative		-0,81	-
PF13_0130	vacuolar ATP synthase subunit G, putative		-0,82	-
PFE0965c	vacuolar ATP synthetase, subunit C putative		-0,85

Gene ID: identifier as found in PlasmoDB.
Art columns: log ratios of gene expression under artesunate exposure at 90 minutes and 3 hours.
HS and CQ columns: over (+) or under (-) expression.
Results were compared with transcriptome modifications induced by heat-shock (HS) [12] and chloroquine (CQ) [8].
Genes involved in transport were selected from the pathway maps of Ginsburg [16].

ISSN: 1471-2164