Dynamic RNA profiling in Plasmodium falciparum synchronized blood stages exposed to lethal doses of artesunate

BMC Genomics

Table 4 Differentially expressed genes involved in lipid metabolism in artesunate-treated cells

Gene ID	Description	ART 90 min	ART 3 h	HS
MAL13P1.485	acyl-coa ligase antigen		0,94
PFB0685c	acyl-CoA synthetase, PfACS9		0,83
PFB0695c	acyl-CoA synthetase	0,88	1,02	+
PF14_0761	fatty acyl CoA synthetase 1 PfACS1		0,99
PF14_0664	biotin carboxylase subunit of acetyl CoA carboxylase, putative	0,97	1,31	+
PF08_0099	acyl CoA binding protein, putative		-0,89
PF10_0016	acyl CoA binding protein, putative		-1,04	-
PFE0410w	triose or hexose phosphate/phosphate translocator, putative		-0,88	-

Gene ID: identifier as found in PlasmoDB.
Art columns: log ratios of gene expression under artesunate exposure at 90 minutes and 3 hours.
HS column: over (+) or under (-) expression.
Results were compared with transcriptome modifications induced by heat-shock (HS) [12] and chloroquine (CQ) [8].
Genes were selected based on [16].

ISSN: 1471-2164