Table 3 Fold changes of the mRNA levels of the apoptosis-related genes in male and female hepatocyte RXRα-deficient mouse livers.
6 month male mice (KO vs. WT) | 6 month female mice (KO vs. WT) | ||||
|---|---|---|---|---|---|
Name | Fold Change | function | Name | Fold Change | function |
FKBP5 | 4.26 | anti-apoptosis | FKBP5 | 2.63 | anti-apoptosis |
USP2 | 3.46 | anti-apoptosis | USP2 | 2.17 | anti-apoptosis |
CFLAR | 2.56 | anti-apoptosis | BCL6 | 2.14 | anti-apoptosis |
BGN | 2.4 | anti-apoptosis | SERPINA3K | 2.06 | anti-apoptosis |
BIK | 4.41 | pro-apoptosis | BGN | -2.12 | anti-apoptosis |
ACVR2B | 3.55 | pro-apoptosis | ANP32A | -2.01 | pro-apoptosis |
BNIP2 | 2.09 | pro-apoptosis | |||
CASP8 | -2.04 | pro-apoptosis | |||
EMP2 | -2.7 | pro-apoptosis | |||
DUSP6 | -4.26 | pro-apoptosis | |||
BCL2L11 | -5.61 | pro-apoptosis | |||
24 month male mice (KO vs. WT) | 24 month female mice (KO vs. WT) | ||||
Name | Fold Change | function | Name | Fold Change | Function |
USP2 | 3.97 | anti-apoptosis | IER3 | 2.23 | anti-apoptosis |
FKBP5 | 2.81 | anti-apoptosis | BCL6 | 2.08 | anti-apoptosis |
IER3 | 2.8 | anti-apoptosis | BIK | 2.22 | pro-apoptosis |
DUSP1 | 2.3 | anti-apoptosis | WNK1 | -2.35 | pro-apoptosis |
BIRC4 | -3.19 | anti-apoptosis | DIABLO | -2.87 | pro-apoptosis |
CASP1 | 2.83 | pro-apoptosis | |||
UBE1L | 2.36 | pro-apoptosis | |||
ZBTB16 | 2.19 | pro-apoptosis | |||
SOX9 | -2.09 | pro-apoptosis | |||
CASP8 | -2.27 | pro-apoptosis | |||