Table 6 Fold changes of the mRNA levels of the cell growth-related genes in male and female hepatocyte RXRα-deficient mouse livers.
6 month male mice (KO vs. WT) | 6 month female mice (KO vs. WT) | ||||
|---|---|---|---|---|---|
Name | Fold Change | function | Name | Fold Change | function |
LCN2 | 6.37 | oncogene | LCN2 | 4.57 | oncogene |
PIM1 | 4.10 | oncogene | GFRA1 | 2.15 | oncogene |
MAFB | 4.07 | oncogene | PTTG1 | -4 | oncogene |
ERBB3 | 2.05 | oncogene | PROM1 | -5.61 | oncogene |
REL | -2.34 | oncogene | PLAGL1 | -2.09 | suppressor |
MDM2) | -2.47 | oncogene | KLF6 | -2.19 | suppressor |
JUN | -2.87 | oncogene | WWOX | -2.2 | suppressor |
RHOB | -2.93 | oncogene | CAPG | -2.23 | suppressor |
PTTG1 | -2.95 | oncogene | KLF4 | -2.32 | suppressor |
RHOC | -3.06 | oncogene | GJA1 | -2.91 | suppressor |
ROS1 | -3.14 | oncogene | GSN | -3.18 | suppressor |
SERTAD1 | -3.7 | oncogene | PEG3 | -5.96 | suppressor |
PML | -3.9 | oncogene | TPM1 | -11.95 | suppressor |
ETS2 | -4.97 | oncogene | |||
FOS | -5.74 | oncogene | |||
MYC | -7.7 | oncogene | |||
SOCS3 | 3.85 | suppressor | |||
MAD1L1 | 3.73 | suppressor | |||
TCF21 | 2.82 | suppressor | |||
CEBPD | 2.77 | suppressor | |||
SSBP2 | 2.27 | suppressor | |||
NDRG1 | 2.19 | suppressor | |||
HMGN1 | 2.1 | suppressor | |||
SLC22A18 | 2.08 | suppressor | |||
AIM1 | 2.05 | suppressor | |||
KSR1 | 2.04 | suppressor | |||
CDKN1A | -2.32 | suppressor | |||
MBL2 | -2.34 | suppressor | |||
GSN | -2.42 | suppressor | |||
TPM1 | -2.46 | suppressor | |||
PSRC1 | -2.78 | suppressor | |||
GPX3 | -2.8 | suppressor | |||
PERP | -3.42 | suppressor | |||
MSX1 | -3.5 | suppressor | |||
MBD1 | -4.15 | suppressor | |||
BTG2 | -5.26 | suppressor | |||
KLF6 | -5.67 | suppressor | |||
EGR2 | -6.03 | suppressor | |||
EGR1 | -15.88 | suppressor | |||
24 month male mice (KO vs. WT) | 24 month female mice (KO vs. WT) | ||||
Name | Fold Change | function | Name | Fold Change | function |
JUN | 2.29 | oncogene | LIMK1 | 4.9 | oncogene |
PTTG1 | 2.25 | oncogene | ROS1 | 4.51 | oncogene |
PLK3 | 3.91 | suppressor | CCND1 | 4.44 | oncogene |
BLNK | 2.13 | suppressor | APC | 2.87 | oncogene |
GPX3 | 2.11 | suppressor | MAFB | 2.57 | oncogene |
BEXL1 | 2.08 | suppressor | MYBL2 | 2.54 | oncogene |
WWOX | -2.00 | suppressor | SH2B2 | 2.25 | oncogene |
PEG3 | -2.2 | suppressor | PDGFB | 2.23 | oncogene |
WISP1 | -3.48 | suppressor | E2F3 | 2.08 | oncogene |
PERP | -4.03 | suppressor | FLT4 | 2.02 | oncogene |
MYCL1 | -2.08 | oncogene | |||
GPC1 | -2.09 | oncogene | |||
CDK5 | -2.11 | oncogene | |||
DCT | -2.3 | oncogene | |||
SH3RF1 | -2.35 | oncogene | |||
NKX2-5 | -2.42 | oncogene | |||
BANP | 3.97 | suppressor | |||
PEG3 | 2.91 | suppressor | |||
IFI16 | 2.63 | suppressor | |||
BLNK | -2.55 | suppressor | |||
DKK3 | -4.13 | suppressor | |||
GPR65 | -6.82 | suppressor | |||