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Table 1 Novel deletions and duplications determined in current study.

From: Novel genome polymorphisms in BCG vaccine strains and impact on efficacy

BCG strains

Polymorphisms

Start

End

Size (bp)

Genes affected

Moreau

Deletion

3244503

3245478

975

fadD26, ppsA

  

4370517

4371645

1128

Rv3887c

Birkhaug/Sweden

Deletion

1158377

1158622

245

trcR

  

3834822

3834932

110

whiB3

Tice

Duplication

2017525

2039587

22062

Rv1782-Rv1800

Birkhaug

Duplication

1

4402007

20813

4411395

30201

Rv3913-Rv0017c

  1. The coordinates correspond to the genome of M. tb H37Rv. The two deletions and DU-Tice were confirmed by PCR application and DNA sequencing.