Global identification of bursicon-regulated genes in Drosophila melanogaster

An, Shiheng; Wang, Songjie; Gilbert, Lawrence I; Beerntsen, Brenda; Ellersieck, Mark; Song, Qisheng

doi:10.1186/1471-2164-9-424

BMC Genomics

Table 1 Microarray identification of the genes that are up- and down-regulated by r-bursicon in the neck-ligated fly assay at 1 and 3 h post r-bursicon injection (≥ 2.0 folds, p < 0.05).

From: Global identification of bursicon-regulated genes in Drosophila melanogaster

		1 h			3 h
Function	Transcript	Gene name or function domain	Fold	Transcript	Gene name or function domain	Fold
Signaling	CG2849-RB	Ras-related protein	3.9	CG17226-RA	Odorant receptor 59c	-2.7
	CG6407-RA	Wnt oncogene analog 5	2.3
	CG11348-RB	Nicotinic acetylchol. receptor	2.1
	CG32659-RA	Tenascin accessory (EGF- Domain)	2.1
	CG2346-RA	FMRFamide-related	2.0
	CG10125-RA	Zero population growth (Innexin domain)	2.0
	CG6386-RA	Ballchen (Kinase domain)	2.0
Immune response	CG10146-RA	Attacin	7.9	CG31193-RA	Humoral factor Turandot X	3.8
	CG33202-RB	(Immunoglobulin domain)	2.3	CG31691-RA	Humoral factor Turandot F	2.3
	CG18372-RA	Attacin	2.0	CG31508-RA	Humoral factor Turandot C	2.2
				CG1878-RA	Cecropin B	2.3
Channel & transporter	CG9500-RA	(Fibrinogen-related domains)	2.4	HDC14466	Magnesium/cobalt transporter	3.0
	CG12348-RA	Shaker (BTB/POZ domain)	2.1	CG10369	Inward rectifier K⁺ channel	2.3
	CG4110-RA	Pickpocket 11 (Sodium channel)	2.0	CG33098-RC	Ca²⁺ sensors & Ca²⁺ signal MODs	2.1
	CG1522-RA	Cacophony (Ion transport protein)	2.0	HDC02744	Iron-sulfur cluster-binding protein	2.0
	CG14872-RB	(Lipocalin/cytosolic fatty-acid binding protein)	2.1	CG10844	Ryanodine-sensitive Ca²⁺-release channel	-2.6
	CG8221-RA	Amyrel (Alpha amylase)	-2.5
Transcription	CG30080- RA	Iduronate-2- like sulfatase	3.0	CG30080- RA	Iduronate-2- like sulfatase	2.1
	CG32491- RA	Modifier of mdg4	2.4	CG32491- RA	Modifier of mdg4	2.4
	CG1624-RC	Dappled (Zinc binding domain)	2.0	CG11501-RA	Transcriptional regulator	9.6
	CG6157-RA	Discontinuous actin hexagon (Zinc binding domain)	2.0
	CG8260-RA	(BTB/POZ domain)	2.0
DNA/RNA binding	CG3497-RA	Suppressor of Hairless (DNA binding domain)	2.4	CG12924-RA	Eukary. Sm & Sm-like (LSm) protein	3.2
	CG3019-RA	Suppressor of white-apricot	2.1	CG32438-RA	SMC5 proteins (ATPase family)	-2.2
	CG8920-RA	Tudor domain	2.1
	CG7776-RA	Enhancer of Polycomb	2.0
	CG10897-RA	Toutatis (Methyl-CpG binding domains)	2.0
	CG10327-RC	TBPH (RNA recognition motif)	2.0
	CG3238-RA	(DUF889 domain)	2.6
Metabolic enzyme	CG12660-RA	Retinal degeneration A (Phorbol-esters/diacylglycerol binding domain)	2.5
	CG13927-RA	γ- glutamyl carboxylase	2.3
	CG10140-RA	Chitin binding Peritrophin-A domain	2.2
	CG6822-RB	Ergic53(Legume lectin domain)	2.1
	CG4181-RA	Glutathione S transferase	2.1
	CG3649-RA	Sugar transporter domain	2.0
Cytoskeletal compnt	CG13338-RA	Cuticular protein 50Ca (Chitin-binding domain)	2.1	CG32050-RA	Titin	2.0
Cell adhesion	CG3938-RE	Cyclin E	2.2	CG16826-RA	Lipoprotein	2.2
				CG7294-RA	Trophinin	2.0
Proteolysis& peptidolysis				CG4793-RB	Trypsin-like serine protease	4.9
				CG11066	Serine-type endopeptidase	2.9
				CG30287-RA	Trypsin-like serine protease	2.1
Unknown function	CG30482-RA	N	2.8	CG7985-RA	N	2.6
	CT32157	N	2.4	HDC18092	N	2.6
	CG16863-RA	N	2.3	HDC15090	N	2.4
	HDC03087	N	2.2	HDC13939	N	2.3
	HDC16822	N	2.2	HDC15545	N	2.2
	CG32027-RA	N	2.2	HDC05639	N	2.0
	HDC09490	N	2.2	HDC14431	N	-2.0
	LD33458	N	2.2	HDC09972	N	-2.1
	CG2217-RA	N	2.1	CT33997	N	-2.2
	CG17816-RA	N	2.1	HDC18592	N	-2.5
	CG40172-RA	N	2.1	CG4440-RA	N	-2.5
	CG31813-RA	N	2.1	S.CX001941	N	-4.0
	GH12319	N	2.0
	CG32132-RA	N	2.0
	CT29521	N	2.0
	CG15699-RA	N	2.0
	CG40386-RA	N	2.1
	HDC10707	N	-2.2

The genes in bold were detected at both 1 and 3 h post r-bursicon injection. The name in parenthesis indicates a functional domain.
N: gene with no known function associated with it.

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ISSN: 1471-2164

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