Table 1 Argonaute protein family functional groups
From: Comparative genomics of small RNA regulatory pathway components in vector mosquitoes
Protein Subfamily | Protein | Small RNA class, length | Putative Function (referenced mosquito studies) |
|---|---|---|---|
Argonaute | Ago1 | miRNA, 20–22 nts | Regulation of endogenous mRNAs during development; control of Plasmodium infection [15, 54] |
Argonaute | Ago2 | siRNA, 20–22 nts | |
PIWI | Ago3 PIWI (Ago4) Aub (Ago5) | piRNA, rasiRNA, 24–30 nts | Germline surveillance, telomere maintenance, anti-viral defense [1], and maintenance of retrotransposon silencing |