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Table 1 Argonaute protein family functional groups

From: Comparative genomics of small RNA regulatory pathway components in vector mosquitoes

Protein Subfamily Protein Small RNA class, length Putative Function (referenced mosquito studies)
Argonaute Ago1 miRNA, 20–22 nts Regulation of endogenous mRNAs during development; control of Plasmodium infection [15, 54]
Argonaute Ago2 siRNA, 20–22 nts Anti-viral defense [1, 2527]
PIWI Ago3 PIWI (Ago4) Aub (Ago5) piRNA, rasiRNA, 24–30 nts Germline surveillance, telomere maintenance, anti-viral defense [1], and maintenance of retrotransposon silencing