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Table 3 Potential Virulence Genes of Aeromonas salmonicida A449

From: The genome of Aeromonas salmonicida subsp. salmonicida A449: insights into the evolution of a fish pathogen

Virulence function ASA Locus A. hydrophila ATCC 7966T orthologue1 Description Reference or Comments2
Secretion 0514–0515 3785–3786 T2SS (ExeAB) [55]
  3774–3785 0568–0579 T2SS (ExeC-N) [56]
  P5G048 – 083 NP3 T3SS structural & regulatory proteins [31]
  P5G008 & 009 NP AopH effector & chaperone [30]
  P5G097 & 098 NP AopO effector & chaperone [30]
  4266 & 4267 NP AexT effector & chaperone [36]
  P5G045 & 046 NP Ati2 putative effector & chaperone [35]
  P5G084 & 085 NP putative T3SS effector & chaperone frameshift
  0010 & 0011 NP putative T3SS effector & chaperone in frame TAA, frameshift
  2455 – 2470 1847 – 1832 T6SS operon 2455 & 2458 disrupted
  P4G080 – 082 1118 – 1119 1826 – 1827 1847 – 1848 T6SS 082 interrupted by Tn21 [39]
Adhesion 1422 – 1459 NP surface layer & assoc. secretion system [40, 44]
  0346 – 0386 NP Lateral flagella 0365, 0376 [45] disrupted
  1336 – 1360 1364 – 1388 Polar flagella  
  1484 – 1499 2847 – 2832 Polar flagella 1499 frameshift
  1505 – 1507 2826 – 2824 Polar flagella 1505 frameshift
  2656 – 2662 1698 – 1703 Polar flagella 2656 frameshift
  3725 – 3730 0519 – 0524 Type I pilus  
  0411 – 0414 3868 – 3671 Tap type IV pilus 0412 frameshift [93]
  2903 – 2915 1462 – 1450 Flp type IV pilus 2906, 2908 & 2913 disrupted [47]
  3938 – 3947 0383 – 0399 Msh type IV pilus multiple gene deletion [47]
Toxins 3906 0438 aerolysin [48]
  2854 1512 hemolysin  
  0826 3491 RTX toxin  
  2128 NP cytolytic δ-endotoxin  
  2003 NP zona occludens toxin frameshift
  2015 NP zona occludens toxin IS insertion
Secreted enzymes 2540 2687 serine protease Ahe2 [51]
  3321 0978 zinc metalloprotease TagA [52]
  3440 0851 elastase AhpB  
  1723 NP metalloprotease  
  3723 0517 collagenase  
  1660 2713 AsaP1 protease frameshift [53]
  0509 3791 glycerophospholipid cholesterol acyltransferase [51]
  4288 0104 phospholipase A1 [54]
  0635 0635 phospholipase C [54]
  1199 3126 extracellular nuclease  
  2206 2180 extracellular nuclease NucH  
  1286 1304 amylase Amy1  
  3455 0837 amylase AmyA  
  0873 3440 chitinase CdxA  
  2142 2363 chitinase Chi2  
  3320 0979 chitinase ChiB  
  0628 0628 pullulanase PulA  
Antibiotic resistance P4G087 – 105 NP Tn21/In2  
  P4G004 – 005 NP tetracycline resist.  
  1191 3135 β-lactamase: ampC [57]
  4346 4258 β- lactamase: ampS [57]
  3612 0740 β- lactamase: cphA [57]
Iron acquisition 1838 – 1851 2479 – 2473 1964 – 1970 amonabactin synthesis & uptake [59, 60]
  4368 – 4380 NP anguibactin synthesis & uptake [59, 62]
  4363 – 4367 4275 – 4279 hydroxymate siderophore receptor  
  3328 0972 putative heme receptor [59]
  3332 – 3336 0968 – 0964 heme uptake [63]
Quorum sensing 3762 0556 N-acyl homoserine lactone synthase [65]
  3763 0557 Quorum sensing regulon activator [65]
  0697 0700 AI-2 synthase  
  2781 1576 Quorum sensing phosphorelay protein  
  3295 1004 Quorum sensing response regulator  
  1. 1indicates AHA_ number
  2. 2Disrupted genes are indicated
  3. 3NP – not present in A. hydrophila genome