Table 3 Potential Virulence Genes of Aeromonas salmonicida A449
Virulence function | ASA Locus | A. hydrophila ATCC 7966T orthologue1 | Description | Reference or Comments2 |
|---|---|---|---|---|
Secretion | 0514–0515 | 3785–3786 | T2SS (ExeAB) | [55] |
|  | 3774–3785 | 0568–0579 | T2SS (ExeC-N) | [56] |
|  | P5G048 – 083 | NP3 | T3SS structural & regulatory proteins | [31] |
| Â | P5G008 & 009 | NP | AopH effector & chaperone | [30] |
| Â | P5G097 & 098 | NP | AopO effector & chaperone | [30] |
| Â | 4266 & 4267 | NP | AexT effector & chaperone | [36] |
| Â | P5G045 & 046 | NP | Ati2 putative effector & chaperone | [35] |
| Â | P5G084 & 085 | NP | putative T3SS effector & chaperone | frameshift |
| Â | 0010 & 0011 | NP | putative T3SS effector & chaperone | in frame TAA, frameshift |
|  | 2455 – 2470 | 1847 – 1832 | T6SS operon | 2455 & 2458 disrupted |
|  | P4G080 – 082 | 1118 – 1119 1826 – 1827 1847 – 1848 | T6SS | 082 interrupted by Tn21 [39] |
Adhesion | 1422 – 1459 | NP | surface layer & assoc. secretion system | |
|  | 0346 – 0386 | NP | Lateral flagella | 0365, 0376 [45] disrupted |
|  | 1336 – 1360 | 1364 – 1388 | Polar flagella |  |
|  | 1484 – 1499 | 2847 – 2832 | Polar flagella | 1499 frameshift |
|  | 1505 – 1507 | 2826 – 2824 | Polar flagella | 1505 frameshift |
|  | 2656 – 2662 | 1698 – 1703 | Polar flagella | 2656 frameshift |
|  | 3725 – 3730 | 0519 – 0524 | Type I pilus |  |
|  | 0411 – 0414 | 3868 – 3671 | Tap type IV pilus | 0412 frameshift [93] |
|  | 2903 – 2915 | 1462 – 1450 | Flp type IV pilus | 2906, 2908 & 2913 disrupted [47] |
|  | 3938 – 3947 | 0383 – 0399 | Msh type IV pilus | multiple gene deletion [47] |
Toxins | 3906 | 0438 | aerolysin | [48] |
| Â | 2854 | 1512 | hemolysin | Â |
| Â | 0826 | 3491 | RTX toxin | Â |
|  | 2128 | NP | cytolytic δ-endotoxin |  |
| Â | 2003 | NP | zona occludens toxin | frameshift |
| Â | 2015 | NP | zona occludens toxin | IS insertion |
Secreted enzymes | 2540 | 2687 | serine protease Ahe2 | [51] |
| Â | 3321 | 0978 | zinc metalloprotease TagA | [52] |
| Â | 3440 | 0851 | elastase AhpB | Â |
| Â | 1723 | NP | metalloprotease | Â |
| Â | 3723 | 0517 | collagenase | Â |
| Â | 1660 | 2713 | AsaP1 protease | frameshift [53] |
| Â | 0509 | 3791 | glycerophospholipid cholesterol acyltransferase | [51] |
| Â | 4288 | 0104 | phospholipase A1 | [54] |
| Â | 0635 | 0635 | phospholipase C | [54] |
| Â | 1199 | 3126 | extracellular nuclease | Â |
| Â | 2206 | 2180 | extracellular nuclease NucH | Â |
| Â | 1286 | 1304 | amylase Amy1 | Â |
| Â | 3455 | 0837 | amylase AmyA | Â |
| Â | 0873 | 3440 | chitinase CdxA | Â |
| Â | 2142 | 2363 | chitinase Chi2 | Â |
| Â | 3320 | 0979 | chitinase ChiB | Â |
| Â | 0628 | 0628 | pullulanase PulA | Â |
Antibiotic resistance | P4G087 – 105 | NP | Tn21/In2 |  |
|  | P4G004 – 005 | NP | tetracycline resist. |  |
|  | 1191 | 3135 | β-lactamase: ampC | [57] |
|  | 4346 | 4258 | β- lactamase: ampS | [57] |
|  | 3612 | 0740 | β- lactamase: cphA | [57] |
Iron acquisition | 1838 – 1851 | 2479 – 2473 1964 – 1970 | amonabactin synthesis & uptake | |
|  | 4368 – 4380 | NP | anguibactin synthesis & uptake | |
|  | 4363 – 4367 | 4275 – 4279 | hydroxymate siderophore receptor |  |
| Â | 3328 | 0972 | putative heme receptor | [59] |
|  | 3332 – 3336 | 0968 – 0964 | heme uptake | [63] |
Quorum sensing | 3762 | 0556 | N-acyl homoserine lactone synthase | [65] |
| Â | 3763 | 0557 | Quorum sensing regulon activator | [65] |
| Â | 0697 | 0700 | AI-2 synthase | Â |
| Â | 2781 | 1576 | Quorum sensing phosphorelay protein | Â |
| Â | 3295 | 1004 | Quorum sensing response regulator | Â |