The interaction network formed by the 12 identified heat-responsive TFs. An oval indicates an identified heat-responsive TF. A TF name is colored blue if it is known to be involved in heat shock response but black otherwise. Two ovals are connected by an undirected red line if the two TFs have physical interactions indicated by the current protein-protein interaction data . Two ovals are connected by a directed green line if these two TFs have genetic interactions indicated by the mutant or ChIP-chip data [20, 21]. Note that the 12 identified heat-responsive TFs form a highly connected network of interactions.