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Table 1 Highly conserved genes with an E(CG)-bearing promoter.

From: Evolution of the holozoan ribosome biogenesis regulon

A – Human genes with E(CG)-bearing promoters across bilaterian orthologs
ABCF1* ESF1* NOL11* RIOK1*
ATHL1 GNL2* NOL14* RPL11*
BXDC1* GRWD1* NOL5_HUMAN* RPL8*
BXDC5* HEATR1* NOL5A* RRP12*
BYSL* HTF9C_HUMAN* NOL6* RRP9*
C1orf107* IMP4* NOLA1* RRS1*
C1orf181* KAD6_HUMAN* NP_060822.2* SDAD1*
C6orf66 KIAA0020* NP_079425.3 SRM*
CCDC86* KIAA0409* PAQR3 SURF6*
CEBPZ* KLHDC4 PFAS TIMM10
CIRH1A* LYAR* PNO1* TRMT1*
DDX18* MBIP POLR1B* UMPS
DDX51* MEN1 POLR1E* UTP20*
DDX52* MRTO4* POLRMT WDR3*
DDX54* MYBBP1A* PRMT3 WDR36*
DHX37* NAT10* PWP1* WDR75*
DPH5 NHP2L1* PWP2* WDR89
DUS3L* NLE1* QTRTD1*  
EBAG9 NM_005452* RBM19*  
ELP3 NOL1* RCL1*  
B – Human genes with E(CG)-bearing promoters across holozoan orthologs
ATIC EBNA1BP2* MRTO4* PRMT3*
BMS1L* ESF1* NAT10* PWP1*
BXDC1* EXOSC1* NHP2L1* PWP2*
BXDC5* FARSLB* NLE* SLC25A32
BYSL* GTPBP9 NOL14* SRM*
DDX4 KAD6_HUMAN* NOP5* TRMT1*
DDX54* KLF15 PNO1* VPS29
DHX37* LYAR* POLR3K*  
DPH5 MCCC2 PRDX4  
  1. (A) A list of all human genes with orthologous fly genes containing an E(CG) tightly linked to the core promoter in both orthologs. These genes have an E(CG) ± 600 bp and ± 80 bp from the transcriptional initiation site in the pair of human and fly orthologs, respectively. Genes with asterisks are known to be involved in ribosome biogenesis. See Additional file 1 for a more exhaustive list of genes described in this study. (B) A list of all human genes that have been evolutionarily maintained with E(CG)-bearing promoters across orthologous holozoan loci (humans, flies, cnidarians, and choanoflagellates). These genes have an E(CG) ± 600 bp from the annotated 5'-end in each genome. Missing from this list are genes that may be E(CG)-bearing in a genome but are not yet annotated by full-length transcripts. Genes with asterisks are known to be involved in ribosome biogenesis. See Additional file 1 for a more exhaustive list of genes described in this study.