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Table 1 Effect of [BF/S+L/Ep] on gene expression in human iDCs

From: Genomics and proteomics of immune modulatory effects of a butanol fraction of echinacea purpurea in human dendritic cells

   

Fold Change

Gene Name

Common Name

Accession No

Treatment/Control

   

(From 31 to 11-fold)

(A) Up-regulated at 4 h post-treatment

EH-domain containing 1

EHD1

NM_006795

31.81

chemokine (C-C motif) ligand 2

CCL2

NM_002982

22.15

cryptochrome 1 (photolyase-like)

CRY1

NM_004075

21.65

BCL-6 interacting corepressor

BCOR

NM_017745

21.62

tumor necrosis factor receptor superfamily, member 4

TNFRSF4

NM_003327

19.10

Xenopus prevents mitotic catastrophe 2 homolog

XPMC2H

NM_020385

17.54

basic transcription element binding protein 1

BTEB1

NM_001206

17.45

Janus kinase 2 (a protein tyrosine kinase)

JAK2

NM_004972

16.40

wingless-type MMTV integration site family, member 5A

WNT5A

NM_003392

15.42

discs, large (Drosophila) homolog 1

DLG1

NM_004087

15.22

RAB35, member RAS oncogene family

RAB35

NM_006861

14.79

hypothetical protein DKFZp564O0523

DKFZP564O0523

AL136619

14.17

triple functional domain (PTPRF interacting)

TRIO

NM_007118

14.12

zinc finger and BTB domain containing 1

ZBTB1

NM_014950

13.75

chemokine (C-C motif) ligand 5

CCL5

NM_002985

13.62

TRAF family member-associated NF-κB activator

TANK

BC003388

13.12

Interleukin 8

IL8

NM_000584

12.16

HSPCO34 protein

LOC51668

NM_016126

11.37

suppression of tumorigenicity

ST7

NM_013437

11.37

chemokine (C-X-C motif) ligand 2

CXCL2

NM_002089

10.77

Down-regulated at 4 h post-treatment

(From 0.49 to 0.47-fold)

transducin (beta)-like 2 isoform 1

TBL2

NM_012453

0.50

decorin isoform a preproprotein

DCN

NM_001920

0.50

nucleolar protein family A, member 2

NOLA2

NM_017838

0.50

leukocyte immunoglobulin-like receptor

LILRB3

NM_006864

0.50

calpain 3 isoform a

CAPN3

NM_000070

0.49

interferon, alpha 16

IFNA16

NM_002173

0.49

chromosome 5 open reading frame 4

C5ORF4

NM_016348

0.49

tripartite motif-containing 45

TRIM45

NM_025188

0.49

A kinase (PRKA) anchor protein 7 isoform alpha

AKAP7

NM_004842

0.49

carbonic anhydrase IV precursor

CA4

NM_000717

0.49

uncoupling protein 3 isoform UCP3L

UCP3

NM_003356

0.49

NICE-4 protein

NICE-4

NM_014847

0.48

alpha 2 type V collagen preproprotein

COL5A2

NM_000393

0.48

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a3

SMARCA3

NM_003071

0.48

CD27-binding (Siva) protein isoform 1

SIVA

NM_006427

0.48

prostate derived STE20-like kinase PSK

PSK

NM_016151

0.48

stanniocalcin 2

STC2

NM_003714

0.48

arginine-glutamic acid dipeptide (RE) repeats

RERE

NM_012102

0.48

stimulated by retinoic acid gene 6

FLJ12541

NM_022369

0.48

zinc finger protein 228

ZNF228

NM_013380

0.48

   

Fold Change

Gene Name

Common Name

Accession No

Treatment/Control

   

(From 28 to 4.6-fold)

(B) Up-regulated at 24 h post-treatment

 

protein tyrosine phosphatase, non-receptor type 2

PTPN2

NM_002828

28.77

solute carrier family 26, member 4

SLC26A4

NM_000441

25.07

adaptor-related protein complex 4, sigma 1 subunit

AP4S1

NM_007077

23.91

zinc finger protein RINZF

RINZF

NM_023929

15.88

calbindin 1, 28kDa

CALB1

NM_004929

15.57

chromosome 9 open reading frame 10

C9ORF10

AF214738

12.75

secreted frizzled-related protein 1

SFRP1

NM_003012

10.17

cholinergic receptor, nicotinic, alpha polypeptide 5

CHRNA5

NM_000745

9.95

chorea acanthocytosis

CHAC

AB023203

9.91

WAP four-disulfide core domain 8

WFDC8

AL133571

8.68

tripartite motif-containing 45

TRIM45

NM_025188

8.34

matrix metalloproteinase 2

MMP2

NM_004530

6.73

hook1 protein

HOOK1

NM_015888

6.52

epidermal growth factor receptor pathway substrate 8-related protein 1

EPS8R1

AI343292

6.23

zinc finger protein (ZFD25)

ZFD25

NM_016220

5.27

SUMO-1-specific protease

SUSP1

NM_015571

5.02

nuclear respiratory factor 1

NRF1

NM_005011

4.97

phosphoribosyl pyrophosphate amidotransferase

PPAT

NM_002703

4.86

pleckstrin homology-like domain, family A, member 1

PHLDA1

NM_007350

4.79

vascular Rab-GAP/TBC-containing

VRP

NM_000993

4.61

Down-regulated at 24 h post-treatment

(From 0.03 to 0.24-fold)

Chromosome 1 open reading fram 29

C1ORF29

NM_006820

0.04

protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1

PIN1

NM_006221

0.04

myxovirus resistance protein 1

MX1

NM_002462

0.09

sialoadhesin precursor

SN

NM_023068

0.10

interferon-induced protein with tetratricopeptide repeats 1

IFIT1

NM_001548

0.12

axonemal dynein heavy chain 7

DNAH7

NM_018897

0.13

ubiquitin specific protease 18

USP18

NM_017414

0.14

regulator of G-protein signaling 12

RGS12

NM_002926

0.14

interferon-induced, hepatitis C-associated microtubular aggregate

IFI44

NM_006417

0.16

secreted protein of unknown function

SPUF

NM_013349

0.17

vacuolar protein sorting 41 (yeast homolog) isoform 1

VPS41

NM_014396

0.18

SP140 nuclear body protein

SP140

NM_007237

0.19

interferon, alpha-inducible protein

G1P2

NM_005101

0.19

interferon-induced protein with tetratricopeptide repeats 4

IFIT4

NM_001549

0.21

small inducible cytokine B11 precursor

CXCL11

NM_005409

0.29

phospholipid scramblase 1

PLSCR1

NM_021105

0.22

viperin

CIG5

NM_080657

0.22

muscle-specific beta 1 integrin binding protein

MIBP

NM_170678

0.23

translation initiation factor IF2

IF2

NM_015904

0.25

serine (or cysteine) proteinase inhibitor, clade A, member 1

SERPINA1

NM_000295

0.25

  1. Top 20 genes up- or down-regulated in human immature DCs in response to treatment with (BF/S+L/Ep) fraction of Echinacea purpurea for 4 h (A) or 24 h (B) by fold change in expression.