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Table 1 Effect of [BF/S+L/Ep] on gene expression in human iDCs

From: Genomics and proteomics of immune modulatory effects of a butanol fraction of echinacea purpurea in human dendritic cells

    Fold Change
Gene Name Common Name Accession No Treatment/Control
    (From 31 to 11-fold)
(A) Up-regulated at 4 h post-treatment
EH-domain containing 1 EHD1 NM_006795 31.81
chemokine (C-C motif) ligand 2 CCL2 NM_002982 22.15
cryptochrome 1 (photolyase-like) CRY1 NM_004075 21.65
BCL-6 interacting corepressor BCOR NM_017745 21.62
tumor necrosis factor receptor superfamily, member 4 TNFRSF4 NM_003327 19.10
Xenopus prevents mitotic catastrophe 2 homolog XPMC2H NM_020385 17.54
basic transcription element binding protein 1 BTEB1 NM_001206 17.45
Janus kinase 2 (a protein tyrosine kinase) JAK2 NM_004972 16.40
wingless-type MMTV integration site family, member 5A WNT5A NM_003392 15.42
discs, large (Drosophila) homolog 1 DLG1 NM_004087 15.22
RAB35, member RAS oncogene family RAB35 NM_006861 14.79
hypothetical protein DKFZp564O0523 DKFZP564O0523 AL136619 14.17
triple functional domain (PTPRF interacting) TRIO NM_007118 14.12
zinc finger and BTB domain containing 1 ZBTB1 NM_014950 13.75
chemokine (C-C motif) ligand 5 CCL5 NM_002985 13.62
TRAF family member-associated NF-κB activator TANK BC003388 13.12
Interleukin 8 IL8 NM_000584 12.16
HSPCO34 protein LOC51668 NM_016126 11.37
suppression of tumorigenicity ST7 NM_013437 11.37
chemokine (C-X-C motif) ligand 2 CXCL2 NM_002089 10.77
Down-regulated at 4 h post-treatment (From 0.49 to 0.47-fold)
transducin (beta)-like 2 isoform 1 TBL2 NM_012453 0.50
decorin isoform a preproprotein DCN NM_001920 0.50
nucleolar protein family A, member 2 NOLA2 NM_017838 0.50
leukocyte immunoglobulin-like receptor LILRB3 NM_006864 0.50
calpain 3 isoform a CAPN3 NM_000070 0.49
interferon, alpha 16 IFNA16 NM_002173 0.49
chromosome 5 open reading frame 4 C5ORF4 NM_016348 0.49
tripartite motif-containing 45 TRIM45 NM_025188 0.49
A kinase (PRKA) anchor protein 7 isoform alpha AKAP7 NM_004842 0.49
carbonic anhydrase IV precursor CA4 NM_000717 0.49
uncoupling protein 3 isoform UCP3L UCP3 NM_003356 0.49
NICE-4 protein NICE-4 NM_014847 0.48
alpha 2 type V collagen preproprotein COL5A2 NM_000393 0.48
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a3 SMARCA3 NM_003071 0.48
CD27-binding (Siva) protein isoform 1 SIVA NM_006427 0.48
prostate derived STE20-like kinase PSK PSK NM_016151 0.48
stanniocalcin 2 STC2 NM_003714 0.48
arginine-glutamic acid dipeptide (RE) repeats RERE NM_012102 0.48
stimulated by retinoic acid gene 6 FLJ12541 NM_022369 0.48
zinc finger protein 228 ZNF228 NM_013380 0.48
    Fold Change
Gene Name Common Name Accession No Treatment/Control
    (From 28 to 4.6-fold)
(B) Up-regulated at 24 h post-treatment  
protein tyrosine phosphatase, non-receptor type 2 PTPN2 NM_002828 28.77
solute carrier family 26, member 4 SLC26A4 NM_000441 25.07
adaptor-related protein complex 4, sigma 1 subunit AP4S1 NM_007077 23.91
zinc finger protein RINZF RINZF NM_023929 15.88
calbindin 1, 28kDa CALB1 NM_004929 15.57
chromosome 9 open reading frame 10 C9ORF10 AF214738 12.75
secreted frizzled-related protein 1 SFRP1 NM_003012 10.17
cholinergic receptor, nicotinic, alpha polypeptide 5 CHRNA5 NM_000745 9.95
chorea acanthocytosis CHAC AB023203 9.91
WAP four-disulfide core domain 8 WFDC8 AL133571 8.68
tripartite motif-containing 45 TRIM45 NM_025188 8.34
matrix metalloproteinase 2 MMP2 NM_004530 6.73
hook1 protein HOOK1 NM_015888 6.52
epidermal growth factor receptor pathway substrate 8-related protein 1 EPS8R1 AI343292 6.23
zinc finger protein (ZFD25) ZFD25 NM_016220 5.27
SUMO-1-specific protease SUSP1 NM_015571 5.02
nuclear respiratory factor 1 NRF1 NM_005011 4.97
phosphoribosyl pyrophosphate amidotransferase PPAT NM_002703 4.86
pleckstrin homology-like domain, family A, member 1 PHLDA1 NM_007350 4.79
vascular Rab-GAP/TBC-containing VRP NM_000993 4.61
Down-regulated at 24 h post-treatment (From 0.03 to 0.24-fold)
Chromosome 1 open reading fram 29 C1ORF29 NM_006820 0.04
protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1 PIN1 NM_006221 0.04
myxovirus resistance protein 1 MX1 NM_002462 0.09
sialoadhesin precursor SN NM_023068 0.10
interferon-induced protein with tetratricopeptide repeats 1 IFIT1 NM_001548 0.12
axonemal dynein heavy chain 7 DNAH7 NM_018897 0.13
ubiquitin specific protease 18 USP18 NM_017414 0.14
regulator of G-protein signaling 12 RGS12 NM_002926 0.14
interferon-induced, hepatitis C-associated microtubular aggregate IFI44 NM_006417 0.16
secreted protein of unknown function SPUF NM_013349 0.17
vacuolar protein sorting 41 (yeast homolog) isoform 1 VPS41 NM_014396 0.18
SP140 nuclear body protein SP140 NM_007237 0.19
interferon, alpha-inducible protein G1P2 NM_005101 0.19
interferon-induced protein with tetratricopeptide repeats 4 IFIT4 NM_001549 0.21
small inducible cytokine B11 precursor CXCL11 NM_005409 0.29
phospholipid scramblase 1 PLSCR1 NM_021105 0.22
viperin CIG5 NM_080657 0.22
muscle-specific beta 1 integrin binding protein MIBP NM_170678 0.23
translation initiation factor IF2 IF2 NM_015904 0.25
serine (or cysteine) proteinase inhibitor, clade A, member 1 SERPINA1 NM_000295 0.25
  1. Top 20 genes up- or down-regulated in human immature DCs in response to treatment with (BF/S+L/Ep) fraction of Echinacea purpurea for 4 h (A) or 24 h (B) by fold change in expression.