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Table 2 Summary of data for select known and novel wt p53 targets

From: p53 induces distinct epigenetic states at its direct target promoters

gene name

binding p-value

enrichment microarray

enrichment real-time PCR

H3

H4

expression change

PLK3

5.24E-18

2.3

11.7

1.7*

2.0*

2.7

FAS

1.26E-16

1.9

6.6

1.1

1.1

2.9

APAF1

9.04E-16

1.5

3.2

1.4*

1.3

3.7

FBXO22*

9.64E-14

1.6

6.1

1.3*

1.2

3.1

DDB2

1.19E-10

1.3

4.2

1.1

1.0

3.4

DGKZ*

1.12E-09

1.5

4.5

1.8*

1.7*

2.1

MASPIN

4.81E-08

1.2

5.4

1.3*

1.1

1.9

SEMA3B

2.31E-07

1.2

3.6

1.4

1.3

14.3

GDF9*

7.69E-06

1.3

2.4

1.2*

1.2

246.1

SYK*

1.33E-04

1.2

1.6

1.1

1.0

3.7

CSPG2

1.38E-04

1.1

1.5

1.5*

1.3*

8.6

PLXNB3*

3.81E-04

1.2

1.6

1.4*

1.1

9.4

RPS27L

1.58E-03

1.2

4.8

1.4

1.3*

4.0

  1. Novel direct p53 target genes are marked with an asterisk. The p-value column displays the p-value of enrichment of p53 ChIP sample over input detected by the microarray. The next two columns display fold enrichment of ChIP sample over input detected by microarray hybridization or real-time PCR, respectively. The histone H3 and H4 columns display fold changes in histone acetylation relative to the control cell lines. Significant changes (p-val ≤ 0.05) in histone acetylation are marked with an asterisk. The expression column displays fold increase in expression, detected by real-time RT-PCR, relative to control.
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BMC Genomics

ISSN: 1471-2164

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