Figure 1

Relative liver weight and tissue level analysis. (A) Relative liver weight. Immature ovariectomized C57BL/6 mice were orally administered 300 mg/kg o, p'-DDT or sesame oil vehicle at time 0, 24 and 48 h. Mice were sacrificed 2, 4, 8, 12, 18, 24 or 72 h after the initial dose. The relative liver weight was significantly increased at 72 h. (B) Hepatic concentration of o, p'-DDT and o, p'-DDD. (C) Hepatic concentration of o, p'-DDE. Hepatic tissue levels of o, p'-DDT, o, p'-DDD and o, p'-DDE were determined using high-resolution gas chromatograph/HRMS from three randomly selected mice orally gavaged with 300 mg/kg o, p'-DDT. The data are presented as mean ± SE. The asterisk (*) indicates a significant (p < 0.05) difference from the vehicle controls.