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Table 1 Selected microarray results

From: Species-specific regulation of PXR/CAR/ER-target genes in the mouse and rat liver elicited by o, p'-DDT

Gene symbol

Entrez GeneID

Gene expression ratio (h)a

  

2

4

8

12

18

24

72

Drug metabolizing enzyme

Cyp1a1

13076

1.22

1.22

1.22

2.16

1.78

1.92

1.42

Cyp1a2

13077

1.16

1.26

1.30

1.61

1.50

2.29

1.30

Cyp2b9

13094

1.78

1.90

2.41

4.11

3.75

4.97

2.23

Cyp2b10

13088

2.19

2.12

2.69

11.37

12.47

18.42

4.29

Cyp2b13

13089

1.49

1.36

1.46

3.79

3.54

4.09

2.04

Cyp2c39

13098

1.25

1.41

1.23

1.51

1.60

2.13

1.72

Cyp2c55

72082

1.71

3.19

7.43

15.18

30.38

36.40

7.70

Reductive reaction

Gsta1

14857

1.30

0.91

1.39

1.76

3.00

3.42

2.37

Gsta2

14858

1.53

0.83

2.23

3.52

7.01

6.60

2.91

Gstm2

14863

1.03

1.14

2.20

2.06

2.44

3.19

1.90

Gstt3

103140

1.22

1.17

1.81

2.31

2.18

2.65

1.62

Ugt2b35

243085

1.13

1.17

1.94

2.73

2.30

3.38

2.53

DNA damage/apoptosis

Casp9

12371

1.01

0.67

0.62

0.61

0.64

0.75

0.83

Cdkn1a

12575

2.53

15.36

3.37

2.27

0.75

1.54

1.00

Fas

14102

0.94

0.89

0.78

0.80

0.85

0.66

0.72

Gadd45a

13197

2.96

12.58

13.54

8.52

3.16

1.41

2.29

Gadd45b

17873

4.55

8.35

6.66

7.83

5.12

6.80

3.32

Tnfrsf19

29820

1.22

1.75

5.86

4.29

1.67

1.66

2.21

Metabolism

ApoA4

11808

1.15

1.05

4.31

5.03

5.74

3.54

3.34

Ces2

234671

1.16

1.46

1.68

2.22

2.11

3.36

3.05

Cyp17a1

13074

1.43

1.27

3.97

6.24

5.52

3.68

1.88

Cyp51

13121

0.98

1.02

0.85

0.39

0.72

0.35

0.49

Cyp7a1

13122

1.07

0.58

0.25

0.44

0.66

0.51

1.09

Cyp7b1

13123

0.98

1.51

3.05

5.77

4.15

5.44

3.41

Insig2

72999

2.80

5.00

4.40

4.63

1.45

2.36

0.81

Srebf1

20787

0.94

0.51

0.31

0.21

0.70

0.47

0.31

Cell proliferation

Ccnb2

12442

0.94

0.84

0.82

0.49

0.68

0.86

0.83

Ccnd1

12443

0.71

1.17

1.08

0.85

2.32

0.78

0.66

Ccng2

12452

1.26

1.66

1.39

0.71

0.34

1.03

0.95

Mdm2

17246

1.13

1.19

1.16

1.11

0.97

1.09

1.28

Stmn1

16765

0.74

1.00

0.69

0.35

0.59

0.84

0.60

Oxidative stress

Gclm

14630

1.06

1.15

1.36

1.54

1.33

1.59

1.50

Gsr

14782

1.02

1.40

2.03

2.47

2.39

2.54

2.33

Hmox2

15369

1.18

1.55

1.44

1.39

1.40

1.52

1.43

Nqo1

18104

0.99

1.10

1.71

1.97

2.57

2.35

2.43

Transcription factor/signal transuction

Ahr

11622

1.20

1.43

1.29

1.50

0.96

1.47

1.15

Nr1i2 (PXR)

18171

1.16

1.63

1.74

1.62

1.90

1.68

1.44

Nr1i3 (CAR)

12355

1.12

1.20

0.58

0.91

1.18

1.29

1.38

  1. a Highlighted values indicate expression ratio where p1(t) > 0.999.
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BMC Genomics

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