Skip to main content
Figure 3 | BMC Genomics

Figure 3

From: Ploidy status and copy number aberrations in primary glioblastomas defined by integrated analysis of allelic ratios, signal ratios and loss of heterozygosity using 500K SNP Mapping Arrays

Figure 3

Copy number changes in a diploid background. Each panel shows an integrated view of log ratios (LR), allelic ratios (AR) and LOH. (A) A single copy gain in the q-arm of the disomic Chr:1 in C82 is detected by a 0.25 increase in the log ratio and a shift in the AR to a trisomy pattern (i.e., from 0.5 to 0.33 and 0.67). (B) A single copy loss in the p-arm of Chr:5 in C156 is detected by a -0.4 decrease in the log ratio and a shift in the AR to a monosomic pattern. The loss is accompanied by a collinear region of LOH (indicated by the long blue rectangle on the LOH bar). (C) A complex series of CNAs on Chr:7 in C92 is paralleled by changes in the ARs. Note that the entire q-arm is trisomic, and the strong amplification event on the p-arm adjacent to the centromere (indicated by an arrow) shifts the AR to extreme values and generates a collinear segment of LOH.

Back to article page

BMC Genomics

ISSN: 1471-2164

Contact us