Table 1 Gene ontology categories most affected by TNBS colitis at different time points
Gene ontology category | z value | ||
|---|---|---|---|
Day 2 | Biological process | Positive regulation of anti-apoptosis | 5.033 |
Leukocyte chemotaxis | 5.199 | ||
Cellular component | Phosphoinositide 3-kinase complex | 4.202 | |
Molecular function | Chemokine activity | 5.721 | |
1-Phosphatidylinositol 3-kinase activity | 4.582 | ||
Unfolded protein binding | 4.022 | ||
Day 5 | Biological process | Immune system process | 6.507 |
Immune response | 6.088 | ||
Defence response | 6.025 | ||
Response to external stimulus | 5.402 | ||
Antigen processing and presentation of peptide antigen via MHC class II | 5.128 | ||
Lymphocyte mediated immunity | 4.962 | ||
Cell death | 4.910 | ||
Response to other organism | 4.532 | ||
Leukocyte migration | 4.506 | ||
Cytokine biosynthetic process | 4.484 | ||
Phagocytosis, recognition | 4.473 | ||
Positive regulation of lymphocyte differentiation | 4.348 | ||
Vasculature development | 4.320 | ||
Protein amino acid dephosphorylation | 4.289 | ||
Regulation of inflammatory response | 4.190 | ||
T cell differentiation | 4.091 | ||
Peptide antigen transport | 4.044 | ||
Regulation of protein binding | 4.001 | ||
Organelle fusion | 4.001 | ||
Cellular component | MHC class II protein complex | 4.900 | |
Mitochondrial respiratory chain | 4.384 | ||
TAP complex | 4.374 | ||
Molecular function | Haematopoietin/interferon-class (D200-domain) cytokine receptor activity | 5.107 | |
Protein tyrosine phosphatase activity | 4.871 | ||
Cytokine activity | 4.600 | ||
Chemokine activity | 4.277 | ||
NADH dehydrogenase activity | 4.133 | ||
Peptide antigen-transporting ATPase activity | 4.044 | ||
Phosphatidylserine binding | 4.001 | ||
Day 7 | Biological process | Leukocyte chemotaxis | 4.936 |
Immune system process | 4.332 | ||
Response to external stimulus | 4.323 | ||
Antigen processing and presentation of exogenous peptide antigen | 4.124 | ||
Cellular component | Extracellular matrix part | 5.849 | |
Proteinaceus extracellular matrix | 4.931 | ||
Collagen | 4.674 | ||
Basement membrane | 4.280 | ||
Actin filament | 4.115 | ||
Molecular function | Extracellular matrix constituent | 4.710 | |
Day 14 | Biological process | Defence response | 5.420 |
Prophyrin catabolic process | 5.286 | ||
Immune response | 5.082 | ||
Lymphocyte homeostasis | 5.029 | ||
DNA damage response, signal transduction by p53 class mediator | 4.414 | ||
Glial cell migration | 4.414 | ||
Leukocyte activation | 4.366 | ||
Inflammatory response | 4.362 | ||
RNA destabilization | 4.316 | ||
Positive regulation of interferon-gamma production | 4.316 | ||
Heme oxidation | 4.316 | ||
Vasodilation | 4.231 | ||
Cytokine biosynthetic process | 4.142 | ||
Cellular component | External side of plasma membrane | 5.339 | |
Costamere | 4.316 | ||
B cell receptor complex | 4.316 | ||
Molecular function | Double-stranded DNA adenosine deaminase activity | 5.286 | |
Interleukin 1, Type I receptor binding | 4.316 | ||
DNA ligase (ATP) activity | 4.316 | ||
Heme oxygenase (decyclizing) activity | 4.316 | ||
Saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity | 4.316 | ||
Thyroid hormone receptor activity | 4.316 | ||
Cannabinoid receptor activity | 4.316 |