Table 5 Hepatic transcripts exhibiting differential expression between the two genotypes (F vs L)1
Biological function | F/L ratio | ANOVA | SAM | ||
|---|---|---|---|---|---|
GenBank Acc. N° | Best-hit Swiss-Prot description | LE diet | HE diet | P-value | FDR cut off |
Lipid metabolism (7.4%) | |||||
BX857103 | Ceramide kinase | -1.6 | -2.8 | < 10-3 | 0.1 |
CA376046 | Nonspecific lipid-transfer protein (NLTP) | 1.4 | 1.1 | 10-3 | 0.1 |
Generation of precursor metabolites and energy (18.5%) | |||||
CA366638 | 10-formyltetrahydrofolate dehydrogenase | 1.8 | 1.5 | < 5.10-4 | 0 |
CA342644 | 6-phosphogluconate dehydrogenase (6-PGDH) | 2.0 | 1.3 | 0.002 | 0.15 |
BX860760 | 10-formyltetrahydrofolate dehydrogenase | 2.0 | 1.9 | 0.003 | 0 |
CA351158 | Malate dehydrogenase, cytoplasmic (MDH) | 1.4 | 1.2 | 0.003 | 0.1 |
BX301878 | Ubiquinol-cytochrome c reductase iron-sulfur subunit | 1.6 | 1.4 | 0.006 | 0.1 |
Carbohydrate metabolism (3.7%) | |||||
BX306300 | Protein phosphatase 1 regulatory subunit 3D | 1.3 | 1.5 | 0.008 | 0.15 |
Amino-acid derivative metabolism (18.5%) | |||||
CA343008 | Betaine-homocysteine S-methyltransferase (BHMT) | 1.5 | 1.2 | < 5.10-4 | 0 |
BX076291 | Aspartate aminotransferase, mitochondrial (GOT2) | 1.6 | 1.2 | 10-3 | 0.1 |
CA353510 | Aspartate aminotransferase, mitochondrial (GOT2) | 1.1 | 1.2 | 0.004 | 0.15 |
CA345122 | 4-aminobutyrate aminotransferase, mitochondrial (GABT) | 1.4 | 1.1 | 0.004 | 0.15 |
CA365793 | Histone H3-K9 methyltransferase 4 | 1.3 | 1.2 | 0.006 | 0.15 |
Protein folding/synthesis/breakdown (18.5%) | |||||
CA345680 | Calpain-9 | 1.3 | 1.1 | < 5.10-4 | 0.15 |
CA362332 | Ubiquitin-conjugating enzyme E2 E1 (UB2E1) | 1.3 | 1.4 | < 10-3 | 0.1 |
CA351453 | α-1,3-mannosyl-glycoprotein | ||||
2-beta-N-acetylglucosaminyltransferase | 1.3 | 1.2 | < 10-3 | 0.1 | |
CA342952 | Proteasome subunit beta type 7 precursor (PSB7) | 1.6 | 1.5 | 0.002 | 0.1 |
BX302854 | Proteasome-associated protein ECM29 homolog | 1.5 | 1.6 | 0.003 | 0.1 |
Xenobiotic and oxidant (22.2%) | |||||
CA359966 | UDP-glucuronosyltransferase 2A1 precursor | 1.3 | 1.6 | < 5.10-4 | 0 |
BX302905 | Metal-regulatory transcription factor 1 | 1.2 | 1.4 | 0.003 | 0.1 |
CA387417 | Stress-activated protein kinase 3 (MK12) | 1.5 | 1.3 | 0.004 | 0.15 |
BX078145 | 7,8-dihydro-8-oxoguanine triphosphatase | 1.8 | 1.0 | 0.004 | 0.15 |
BX305962 | ATP-binding cassette sub-family G member 2 | 1.5 | 1.6 | 0.007 | 0.1 |
BX299516 | Cytochrome P450 2K4 | 1.3 | 1.2 | 0.007 | 0.15 |
Purine and pyrimidine metabolism (15%) | |||||
BX295336 | Nucleoside diphosphate kinase A | -1.3 | -1.1 | < 5.10-4 | 0.15 |
CA381176 | Equilibrative nucleoside transporter 1 | -1.4 | -1.4 | < 10-3 | 0.15 |
Iron metabolism (3.7%) | |||||
BX909008 | Transferrin receptor protein 1 | -1.6 | -1.4 | 0.005 | 0.15 |