Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives

Table 2 Genes specific to affected tissues in Foxa2 mutants are enriched for Gene Ontology (GO) terms.

Affected tissues	GO Term	Specific Term	GO ID	P value* (Average)	E value	Gene Hits (Number)	Gene Hits (Symbols)
Primary:	Molecular function	transcription factor activity	GO:0003700	0.002335	5.08	5	Foxa1 Foxa2
-node							Foxd4
-notochord							Sox17
-anterior							T
mesendoderm	Biological process	anterior/posterior pattern formation	GO:0009952	0.000362	21.11	3	Cer1
-definitive endoderm	Biological process	morphogenesis of an epithelium	GO:0002009	0.000432	19.87	3	Foxa2 T
							Foxa1
							Foxa2
							T
	Biological process	gastrulation	GO:0007369	0.003025	24.25	2	Cer1 Foxa2
	Biological process	notochord development	GO:0030903	0.006329	157.63	1	T
Secondary:	Molecular function	transcription factor activity	GO:0003700	0.000053	4.49	10	Cdx1
							Foxb1
-primitive streak							Gbx2
-cardiac mesoderm							Hesx1
-anterior neuroectoderm							Hoxa1
-vasculature							Meis1
							Meox1
							Nkx1-2
							Six3
							Tbx6
	Biological process	anterior/posterior pattern formation	GO:0009952	0	21.77	7	Aldh1a2
							Dll1
							Gbx2
							Hoxa1
							Meox1
							Six3
							Wnt3a
	Biological process	cardiac muscle morphogenesis	GO:0055008	0.00012	116.09	2	Actc1
							Tnnt2
	Biological process	forebrain development	GO:0030900	0.000392	11.51	4	Aldh1a2
							Fabp7
							Six3
							Wnt3a

ISSN: 1471-2164