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Table 3 Thresholds for Genome Wide Association Using CEU and YRI Population Samples

From: Establishing an adjusted p-value threshold to control the family-wide type 1 error in genome wide association studies

Panel Suggestive p values (1) Significant p values (0.05) Highly Significant p values (0.001)
Affymetrix CEU 500 K (n = 66,923) 1.49 × 10-05 7.47 × 10-07 1.49 × 10-08
Illumina 317 K (n = 82,494) 1.21 × 10-05 6.06 × 10-07 1.21 × 10-08
HapMap YRI (n = 289,175) 3.45 × 10-06 1.73 × 10-07 3.45 × 10-09
HapMap CEU (n = 164,296) 6.09 × 10-06 3.04 × 10-07 6.09 × 10-09
   HapMap CEU (D' > 0.7)* 8.37 × 10-06 4.19 × 10-07 8.37 × 10-09
   HapMap CEU (D' > 0.9)* 4.38 × 10-06 2.19 × 10-07 4.38 × 10-09
  1. *extrapolated from Chromosome 1 data. P-values in parentheses in the header line indicate the family-wide error rate that corresponds to the Bonferroni-corrected significance thresholds given in the columns below.