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Table 1 The temporal pattern of genes up-regulated with IGF-1 treatment

From: Insulin-like growth factor-1 coordinately induces the expression of fatty acid and cholesterol biosynthetic genes in murine C2C12 myoblasts

Affy. Id. Symbol Genes up-regulated at 1 hr only Fold Change
1452519_a_at Zfp36 Zinc finger protein 36 2.2
1450295_s_at Pvr Poliovirus receptor (pvr) 2.2
1427186_a_at Mef2a Myocyte enhancer factor 2A 2.2
1418102_at Hes1 Hairy and enhancer of split 1 2.2
1416442_at Ier2 Immediate early response 2 2.2
   Genes up-regulated at 1 & 2 hrs  
1427683_at Egr2 Early growth response 2 2.6
1427174_at Phlda3 Pleckstrin homology-like dom. family A, member 1 2.4
1419816_s_at Zfp36l2 Zinc finger protein 36, C3H type-like 2 2.4
1418835_at Phlda1 Pleckstrin homology-like dom. family A, member 1 2.4
1437626_at Zfp36l2 Zinc finger protein 36, C3H type-like 2 2.2
1436026_at Zfp703 zinc finger protein 703 2.2
   Genes up-regulated at 1 & 4 hrs  
1421077_at Sertad3 SERTA domain containing 3 2.5
   Genes up-regulated at 1, 2 & 4 hrs  
1455899_x_at Socs3 Suppressor of cytokine signalling 3 5.0
1451382_at Chac Cation transport regulator-like 1 5.0
1428306_at Ddit4 DNA-damage-inducible transcript 4 4.0
1417871_at Hsd17b7 Hydroxysteroid (17-beta) dehydrogenase 7 3.6
1424022_at Osgin1 Oxidative stress induced growth inhibitor 1 3.3
1418025_at Bhlhb2 Basic helix-loop-helix domain containing, class B2 3.3
1416029_at Klf10 Kruppel-like factor 10 3.2
1424709_at Sc5d Sterol-C5-desaturase 3.1
1456212_x_at Socs3 Suppressor of cytokine signaling 3 2.9
1448742_at Snai1 Snail homolog 1 2.9
1448170_at Siah2 Seven in absentia 2 2.7
1434204_x_at Shmt2 Serine hydroxymethyl transferase 2 (mito) 2.2
   Genes up-regulated at 2 hrs only  
1421228_at Ccl7 Chemokine (C-C motif) ligand 7 4.5
1422213_s_at Foxh1 Forkhead box H1 4.5
1449227_at Ch25h Cholesterol 25-hydroxylase 4.0
1438097_at Rab20 RAB20, member RAS oncogene family 3.3
1426706_s_at Xylb Xylulokinase homolog (H. influenzae) 3.3
1421215_a_at Slmap Sarcolemma associated protein 3.1
1428888_at Tmem33 Transmembrane protein 33 clone 3.1
1448125_at Rit2 Ras-like without CAAX 2 3.0
1452402_at Uchl3 Ubiquitin carboxyl-terminal esterase L3 3.0
1452412_at Hoxc8 Homeo box C8 2.9
1426958_at Rps9 Ribosomal protein S9 2.9
1425624_at Epm2aip1 EPM2A (laforin) interacting protein 1 2.8
1427583_at Rik RIKEN cDNA 4921505C17 gene 2.8
1441023_at Eif2s2 Eukaryotic translation initiation factor 2 beta 2.7
1426065_a_at Trib3 Tribbles homolog 3 (Drosophila) 2.6
425362_at Hrb1 HIV-1 Rev binding protein-like 2.6
1424950_at Sox9 SRY-box containing gene 9 2.6
1455904_at Gas5 Growth arrest specific 5 2.5
1456094_at Usp36 Ubiquitin specific peptidase 36 2.5
1449414_at Zfp53 Zinc finger protein 53 2.5
1453806_at Ndufb2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2 2.5
1417597_at Cd28 CD28 antigen 2.5
1422851_at Hmga2 High mobility group AT-hook 2 2.4
1450780_s_at Hmga2 High mobility group AT-hook 2 2.4
1445116_at Usp25 Ubiquitin-specific processing protease 2.4
1425500_x_at Coro2a Coronin, actin binding protein 2A 2.4
1449578_at Supt16h Suppressor of Ty 16 homolog 2.4
1449110_at Rhob Ras homolog gene family, member B 2.3
1425281_a_at Tsc22d3 TSC22 domain family 3 2.3
1437658_a_at Snord22 small nucleolar RNA, C/D box 22 2.3
1420961_a_at Ivns1abp Influenza virus NS1A binding protein 2.3
1421512_at Cep250 Centrosomal protein 250 2.3
1453497_a_at Piga Phosphatidylinositol glycan, class A 2.3
1416693_at Foxc2 Forkhead box C2 2.2
1450781_at Hmga2 High mobility group AT-hook 2 2.2
1438527_at Rpl3 Ribosomal protein L3 2.2
1448171_at Siah2 Seven in absentia 2 2.2
1424607_a_at BC003993 K0208G08-3 NIA Mouse clone 2.2
1420380_at Ccl2 Chemokine (C-C motif) ligand 2 2.2
1417395_at Klf4 Kruppel-like factor 4 2.2
1431030_a_at Rnf14 Ring finger protein 14 2.2
1448183_a_at Hif1a Hypoxia inducible factor 1, alpha subunit 2.1
1419157_at Sox4 SRY-box containing gene 4 2.1
1418158_at Trp63 Transformation related protein 63 2.1
1421000_at Cnot4 CCR4-NOT transcription complex, subunit 4 2.1
1452161_at Tiparp TCDD-inducible poly(ADP-ribose) polymerase 2.0
1425279_at Pdik1l PDLIM1 interacting kinase 1 like 2.0
1453840_at Pabpc1 Poly A binding protein, cytoplasmic 1 2.0
1416123_at Ccnd2 Cyclin D2 2.0
1417924_at Pak3 P21-activated kinase 3 2.0
  1. The temporal pattern of genes up-regulated in mouse myoblasts following IGF-1 treatment is tabulated based on their Venn distribution. Shown are genes up-regulated at: 1 hr only; 1 & 2 hrs; at 1 & 4 hrs; 1, 2 & 4 hrs and 2 hrs only (Please see Additional file 1 for genes up-regulated at 2 & 4 hrs and 4 hrs only).
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BMC Genomics

ISSN: 1471-2164

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