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Table 1 Hubs and clustered nodes in the luminal ER- network.

From: Transcriptome analysis of mammary epithelial subpopulations identifies novel determinants of lineage commitment and cell fate

Hub knode Cnode Differentially expressed neighbours Physical interaction content Transcriptional interaction content
CCL5* 17 0.000 0 35% 65%
TLR4* 17 0.103 2 82% 18%
TNF* 15 0.000 0 13% 87%
BCL2* 14 0.000 2 60% 40%
LY96* 14 0.154 2 100% 0%
KIT* 13 0.013 3 92% 8%
CCL2* 10 0.000 0 40% 60%
LYN* 10 0.022 1 100% 0%
ERBB3* 9 0.194 3 100% 0%
SP1 9 0.000 8 0% 100%
FAS* 8 0.000 0 25% 75%
MUC1* 8 0.143 1 100% 0%
GRB2 7 0.000 6 100% 0%
UBQLN4 7 0.000 6 100% 0%
CD82* 6 0.133 1 100% 0%
KRT18* 6 0.067 1 83% 17%
NFKB1 6 0.000 5 0% 100%
ATXN1 5 0.000 4 100% 0%
CD14* 5 0.100 2 40% 60%
CREB1 5 0.000 4 20% 80%
EGFR 5 0.300 4 100% 0%
ERBB2 5 0.300 4 100% 0%
MAPK1 5 0.000 4 100% 0%
PIK3R1 5 0.000 4 100% 0%
RPS6KA5* 5 0.000 0 100% 0%
SPI1 5 0.000 4 0% 100%
  1. *Differentially-expressed genes. Knode, node connectivity, Cnode, node clustering coefficient, calculated as Cnode = 2 nnode/(knode (knode - 1)) where nnode is the number of interactions between the hub first neighbours. Hubs exhibiting clustering are shown in bold. High content of physical or transcriptional interactions in the hub is shown in bold.
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