Evolution of the chicken Toll-like receptor gene family: A story of gene gain and gene loss

BMC Genomics

Table 2 Function and taxonomic presence of known TLRs

Name we propose	Known host taxa	Ligand	Pathogen	Example accession	References
TLR1	Teleostei	Unknown	Mycobacteria	AC56430	[10]
TLR1LikeA	Aves	Unknown	Unknown	AB109401	[17]
TLR1LikeB	Aves	Unknown	Unknown	DQ518918	[17]
TLR1	Eutheria	Lipopeptide	Bacteria	AY009154	[3]
TLR2	Vertebrata	Lipopeptide and peptidoglycan	G+ bacteria	AC156432, NM_204278, NM_011905	[3]
TLR3	Vertebrata	dsRNA	Viruses	AC156436, NM_001011698, AF355152	[3]
TLR4	Vertebrata, but lost in most teleosts	LPS	G-bacteria	AY388400, AY064697, BC029856	[3, 10]
TLR5	Vertebrata	Flagellin	G-bacteria	AC156437, AJ626848, AF186107	[3]
TLR5S	Teleostei	Flagellin	Bacteria	AB062504	[36]
TLR6	Eutheria	Lipopeptide and Zymosam	Bacteria	BC055366	[3]
TLR7	Vertebrata	Imiquimod	Viruses	AC156438, NM_001011688, AY035889	[3]
TLR8	Teleostei and mammalia	Imiquimod	Viruses	AC15639, AY035890	[3]
TLR9	Teleostei and mammalia	CpG motifs	Bacteria and viruses	AC156432, AF314224	[3]
TLR10	Mammalia	Unknown	Unknown	XM_223422	[3]
TLR11	murinae	Unknown	Unknown	AY501704, XM_373751
TLR12	Mammalia	Profilin	Uropathogenic bacteria	AY351552*, AY510705, XM_342922	[29, 30]
TLR13	Amphibia and Mammalia	Unknown	Unknown	AY510706
TLR14	Amphibia, Teleostei and Hyperoartia	Unknown	Unknown	AC156413	[15]
TLR15	Aves	Unknown	Unknown	XM_19294	[13]
TLR16	Amphibia	Unknown	Unknown		[15]
TLR18	Teleostei	Unknown	Mycobacteria	XM_682223	[10]
TLR19	Teleostei	Unknown	Unknown	XM_68516
TLR20	Teleostei	Unknown	Mycobacteria	no full length sequence available	[10]
TLR21	Teleostei and Aves	Unknown	Unknown	AB101002, NM_001030558	[10, 15]
TLR22	Teleostei	Unknown	Mycobacteria	AC156434	[10]
TLR23	Teleostei	Unknown	Unknown	AC1564345

TLRs are listed in numerical order along with pseudonyms found by this investigation and example GenBank accession numbers. Taxonomic coverage is inferred by the presence of sequences found in this investigation and corresponding phylogenetic data. The PAMP and pathogen data are reported as found in the cited literature.
* incorrectly described as TLR11 in the literature

ISSN: 1471-2164