Sequence divergence of Mus spretus and Mus musculus across a skin cancer susceptibility locus

BMC Genomics

Table 5 Evolutionary conservation of variants seen between M. Spretus strains

Gene	Variant	HS	RN	GG	BT	CF	XT	MD	SIFT
Lamb1-1	Gly1334Asn	Asp	Asp	NH	NH	Asp	NH	NH	0.47
Cog5	Asp538Glu	Asp	Asp	Asp	Asp	Asp	NH	Glu	1
	Asp742Glu	Ser	NH	Asn	Ser	Ser	NH	Arg	0.92
1110049B09rik	Pro691Ala	Pro	Lys	Pro	Pro	Pro	Pro	Pro	0.11
F730043M19Rik	Ser115Leu	NH	NH	NH	NH	NH	NH	NH	0.21
	Asn133Ile	NH	NH	NH	NH	NH	NH	NH	0.00
Twistnb	Asn322Asp	Glu	Asn	Glu	Glu	Glu	Asn	Leu	0.39
Hdac9	Ile265Met	Ile	Ile	Leu	Thr	Ile	Leu	Leu	0.33
	Gly749Ser	Gly	Gly	Gly	Gly	NH	NH	Ala	1.00
	Ala994Val	Val	Ala	Ile	Val	NH	NH	Ile	1.00
Ahr	Asn533Ser	Ser	Ser	Ser	Asn	Ser	Asn	Leu	1.00
	Asn544Asp	Asp	Asp	Asn	Phe	Asp	Asp	Gly	0.66
EG629820	Gly47Ser	NH	NH	NH	NH	NH	NH	NH	0.00
	Gly70Ser	NH	NH	NH	NH	NH	NH	NH	0.00
	Asn72Tyr	NH	NH	NH	NH	NH	NH	NH	0.00
Zfp277	Gln21Phe	Gln	NH	Gln	Gln	Gln	Gln	NH	0.15
	Val434His	Ser	NH	NH	Asn	Arg	NH	Asp	0.08
Lrrn3	Ala69Gln	Ala	Ala	Ala	Ala	Ala	NH	Gln	0.08
	Leu670Val	Phe	Leu	Ile	Phe	Phe	NH	Ile	0.23
	Ala671Val	Ala	Ala	Ser	Ala	Thr	NH	Phe	0.15
DnaJB9	Phe10Leu	Phe	Phe	Phe	Phe	Phe	Phe	Ala	1.00
NrCam	Gln152Arg	Gln	Arg	Arg	Arg	Arg	Gln	Phe	0.49

Bold indicates significant SIFT scores. No known homology (NH), No sift score generated (NSS) M. musculus (MM) Homo sapiens (HS), Rattus norvegicus (RN), Gallus gallus (GG), Bos Taurus (BT), Canis familiaris (CF), Xenopus tropicalis (XP), and Monodelphis domestica (MD).

ISSN: 1471-2164