Figure 4

Bimodal gene enrichment for promoter region methylation of lysine 4 of histone H3 (H3K4me3). A) Fraction of bimodal vs. non-bimodal genes enriched for histone methylation within their promoters as reported by Guenther et al. [12] for H9 hES cells, liver (hepatocytes), and B-cells. The fourth and fifth sets of bars represent the set of genes enriched at high confidence within one tissue but not the other liver versus hES cells and B-cell versus hES cells. B) H3K4me3 enrichment ratio from Guenther et al. [12] for liver vs. stem cells is shown for bimodal genes. Genes expressed with "high" mode in liver and "low" mode in H9 stem cells are shown with green "+" symbols, while bimodal genes expressed with "low" mode in liver and "high" mode in stem cells are shown with blue "x" symbols. Black points are used for the remaining bimodal genes expressed in common modes between these two tissue types. The standard deviation around the line y = x (solid red line) is shown as dashed red lines.